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TRF1 and TRF2 form distinct shelterin subcomplexes at telomeres [PDF]
Cell ReportsSummary: The shelterin complex protects chromosome ends from aberrant DNA repair and regulates telomerase access to telomeres. Shelterin is composed of six proteins (TRF1, TRF2, TIN2, TPP1, POT1, and RAP1) that can assemble into various subcomplexes in ...
Tomáš Janovic +2 more
exaly +4 more sources
Cells, 2021 Protecting telomere from the DNA damage response is essential to avoid the entry into cellular senescence and organismal aging. The progressive telomere DNA shortening in dividing somatic cells, programmed during development, leads to critically short ...
Eric Gilson +2 more
exaly +3 more sources
Shelterin Component TPP1 Drives Tumor Progression and Predicts Poor Prognosis in Hepatocellular Carcinoma [PDF]
BiomedicinesBackground/Objectives: Telomere dysfunction and the shelterin complex are implicated in cancer, yet the specific functions and interactions of telomerase and shelterin genes in hepatocellular carcinoma (HCC) tumorigenesis remain poorly understood.
Jung Eun Jang +9 more
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Discovery of first-in-class inhibitors of the TRF1:TIN2 protein:protein interaction by fragment screening [PDF]
Scientific ReportsTRF1 is a subunit of the shelterin complex that binds to and protects the linear ends of chromosomes known as telomeres. Both genetic deletion and chemical inhibition of TRF1 have been shown to block the growth of lung carcinoma, glioblastoma, and renal ...
Giacomo Casale +8 more
doaj +3 more sources
Combatting cellular immortality in cancers by targeting the shelterin protein complex [PDF]
Biology DirectShelterin proteins (TERF1, TERF2, TPP1, TINF2, POT1) protect telomeres, prevent unwarranted repair activation, and regulate telomerase activity. Alterations in these proteins can lead to cancer progression.
Sohini Chakraborty, Satarupa Banerjee
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Cells, 2020 Telomere comprises the ends of eukaryotic linear chromosomes and is composed of G-rich (TTAGGG) tandem repeats which play an important role in maintaining genome stability, premature aging and onsets of many diseases.
Mohd Amir, Parvez Khan, Aarfa Queen
exaly +3 more sources
The truncated isoform of the receptor for hyaluronan-mediated motility (RHAMMΔ163) modulates shelterin and telomerase reverse transcriptase transcription affecting telomerase activity [PDF]
Frontiers in AgingIntroductionThe receptor for hyaluronan-mediated motility (RHAMM), a centrosomal protein expressing in multiple isoforms, is implicated in telomerase-independent aging. However, its involvement in telomerase regulation is unproven.
Kaustuv Basu
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Comparison of telomere structure in eukaryotes [PDF]
Archives of Razi InstituteTelomeres are DNA-protein complexes located at eukaryotic chromosome ends. Broken chromosome ends fuse to each other; therefore, the role of telomeres is to prevent chromosome end fusion.
Sahar Mansoubi, Mohaddeseh Mohsenpour
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Ccq1–Raf2 interaction mediates CLRC recruitment to establish heterochromatin at telomeres
Life Science Alliance, 2021 This study unveils a role of Ccq1–Raf2 interaction in CLRC recruitment to establish heterochromatin at telomeres, providing a positive feedback mechanism between shelterin and CLRC for subtelomeric heterochromatin assembly.
Shaohua Shi +6 more
doaj +1 more source
PLoS Genetics, 2022 The conserved shelterin complex caps chromosome ends to protect telomeres and regulate telomere replication. In fission yeast Schizosaccharomyces pombe, shelterin consists of telomeric single- and double-stranded DNA-binding modules Pot1-Tpz1 and Taz1 ...
Hong Sun +9 more
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