Shelterins, a genetic crossroad in CLL [PDF]
Blood, 2016 In this issue of Blood , Speedy et al identify germ line loss-of-function mutations involving the telomere shelterin complex in a subset of families with chronic lymphocytic leukemia (CLL ...
Renée Beekman, Elias Campo
openaire +2 more sources
In Vivo Stoichiometry of Shelterin Components [PDF]
Journal of Biological Chemistry, 2010 Human telomeres bind shelterin, the six-subunit protein complex that protects chromosome ends from the DNA damage response and regulates telomere length maintenance by telomerase. We used quantitative immunoblotting to determine the abundance and stoichiometry of the shelterin proteins in the chromatin-bound protein fraction of human cells.
Kaori K, Takai +4 more
openaire +2 more sources
Roles of Specialized Chromatin and DNA Structures at Subtelomeres in Schizosaccharomyces pombe
Biomolecules, 2023 Eukaryotes have linear chromosomes with domains called telomeres at both ends. The telomere DNA consists of a simple tandem repeat sequence, and multiple telomere-binding proteins including the shelterin complex maintain chromosome-end structures and ...
Junko Kanoh
doaj +1 more source
The effect of aerobic exercise and omega-3 on the expression of telomeric repeat binding factor 1 and 2 and telomerase reverse transcriptase enzyme in the heart tissue of elderly HFD rats [PDF]
فیزیولوژی ورزش و فعالیت بدنی, 2023 Background and Purpose: Aging is a complex physiological process that involves progressive loss of body function and degradation of DNA strands located at the ends of chromosomes-telomeres. The capacity of cells to divide is determined by telomere length,
Ghasem Torabi Palat Kaleh +2 more
doaj +1 more source
Tpz1-Ccq1 and Tpz1-Poz1 interactions within fission yeast shelterin modulate Ccq1 Thr93 phosphorylation and telomerase recruitment. [PDF]
PLoS Genetics, 2014 In both fission yeast and humans, the shelterin complex plays central roles in regulation of telomerase recruitment, protection of telomeres against DNA damage response factors, and formation of heterochromatin at telomeres.
Jennifer L Harland +3 more
doaj +1 more source
Fundamental mechanisms of telomerase action in yeasts and mammals: understanding telomeres and telomerase in cancer cells [PDF]
Open Biology, 2017 Aberrant activation of telomerase occurs in 85–90% of all cancers and underpins the ability of cancer cells to bypass their proliferative limit, rendering them immortal.
Christine A. Armstrong +1 more
doaj +1 more source
Shelterin reduces the accessibility of telomeric overhangs
Nucleic Acids Research, 2022 Abstract Telomeres terminate with a 50–300 bases long single-stranded G-rich overhang, which can be misrecognized as a DNA damage repair site. Shelterin plays critical roles in maintaining and protecting telomere ends by regulating access of various physiological agents to telomeric DNA, but the underlying mechanism is not well ...
Sajad Shiekh +9 more
openaire +2 more sources
Asian Pacific Journal of Cancer Prevention, 2015 The telomeric end structures of the DNA are known to contain tandem repeats of TTAGGG sequence bound with specialised protein complex called the "shelterin complex". It comprises six proteins, namely TRF1, TRF2, TIN2, POT1, TPP1 and RAP1. All of these assemble together to form a complex with double strand and single strand DNA repeats at the telomere ...
Trupti Nv, Patel +4 more
openaire +3 more sources
The telosome/shelterin complex and its functions [PDF]
Genome Biology, 2008 The telomeres that cap the ends of eukaryotic chromosomes serve a dual role in protecting the chromosome ends and in intracellular signaling for regulating cell proliferation. A complex of six telomere-associated proteins has been identified--the telosome or shelterin complex--that is crucial for both the maintenance of telomere structure and its ...
Xin, Huawei, Liu, Dan, Songyang, Zhou
openaire +2 more sources
Differential Expression of Non-Shelterin Genes Associated with High Telomerase Levels and Telomere Shortening in Plasma Cell Disorders. [PDF]
PLoS ONE, 2015 Telomerase, shelterin proteins and various interacting factors, named non-shelterin proteins, are involved in the regulation of telomere length (TL). Altered expression of any of these telomere-associated genes can lead to telomere dysfunction, causing ...
Julieta Panero +4 more
doaj +1 more source