Results 11 to 20 of about 4,964 (165)
Cell Reports, 2015 Shelterin, a six-member complex, protects telomeres from nucleolytic attack and regulates their elongation by telomerase. Here, we have developed a strategy, called MICro-MS (Mapping Interfaces via Crosslinking-Mass Spectrometry), that combines ...
Jinqiang Liu +8 more
doaj +6 more sources
Shelterin complex gene: Prognosis and therapeutic vulnerability in cancer
Biochemistry and Biophysics Reports, 2021 Telomere encompasses a (TTAGGG)n tandem repeats, and its dysfunction has emerged as the epicenter of driving carcinogenesis by promoting genetic instability.
Vikas Kumar Bhari +3 more
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Molecular Interplay of PARN and Telomerase: Tail Modifiers and Disease Implications. [PDF]
Wiley Interdiscip Rev RNASchematic representation of the molecular interplay between PARN, telomerase‐associated, and the involvement of p53 in regulating telomere maintenance and genome stability. The top panel shows how normal PARN levels are involved in regulating p53 levels and balanced telomerase activity through their regulatory interaction with TERC and TERRA, thus ...
Felicitus S +5 more
europepmc +2 more sources
The evolution of metazoan shelterin [PDF]
Genes & Development, 2021 The mammalian telomeric shelterin complex—comprised of TRF1, TRF2, Rap1, TIN2, TPP1, and POT1—blocks the DNA damage response at chromosome ends and interacts with telomerase and the CST complex to regulate telomere length. The evolutionary origins of shelterin are unclear, partly because unicellular organisms have distinct telomeric proteins.
Logan R. Myler +5 more
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Rare Germline Variants in CDKN2A-Negative Children and Adolescents With Cutaneous Melanoma. [PDF]
Pigment Cell Melanoma ResIndividuals with childhood and adolescent melanoma carry inherited mutations in shelterin complex genes, pigmentation genes and MBD4, but have fewer MC1R R‐alleles than adults with melanoma. Created with BioRender.com. ABSTRACT Cutaneous melanoma is a complex disease influenced by both environmental and genetic factors. Inherited susceptibility plays a
Johansson PA +10 more
europepmc +2 more sources
Current Biology, 2016 Schmutz and de Lange discuss the shelterin complex, which binds to mammalian telomeres and allows for the natural ends of chromosomes to be distinguished from sites of DNA damage.
Isabelle, Schmutz, Titia, de Lange
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Fission yeast shelterin regulates DNA polymerases and Rad3(ATR) kinase to limit telomere extension. [PDF]
PLoS Genetics, 2013 Studies in fission yeast have previously identified evolutionarily conserved shelterin and Stn1-Ten1 complexes, and established Rad3(ATR)/Tel1(ATM)-dependent phosphorylation of the shelterin subunit Ccq1 at Thr93 as the critical post-translational ...
Ya-Ting Chang +2 more
doaj +1 more source
The shelterin complex and hematopoiesis [PDF]
Journal of Clinical Investigation, 2016 Mammalian chromosomes terminate in stretches of repetitive telomeric DNA that act as buffers to avoid loss of essential genetic information during end-replication. A multiprotein complex known as shelterin prevents recognition of telomeric sequences as sites of DNA damage.
Morgan, Jones +5 more
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Influences of Long-Term Exercise and High-Fat Diet on Age-Related Telomere Shortening in Rats
Cells, 2022 (1) Obesity and exercise are believed to modify age-related telomere shortening by regulating telomerase and shelterins. Existing studies are inconsistent and limited to peripheral blood mononuclear cells (PBMCs) and selected solid tissues.
Maria Donatella Semeraro +4 more
doaj +1 more source
eLife, 2023 The localization of condensin along chromosomes is crucial for their accurate segregation in anaphase. Condensin is enriched at telomeres but how and for what purpose had remained elusive.
Léonard Colin +12 more
doaj +1 more source