Results 31 to 40 of about 4,964 (165)
AKTIP/Ft1, a New Shelterin-Interacting Factor Required for Telomere Maintenance. [PDF]
PLoS Genetics, 2015 Telomeres are nucleoprotein complexes that protect the ends of linear chromosomes from incomplete replication, degradation and detection as DNA breaks. Mammalian telomeres are protected by shelterin, a multiprotein complex that binds the TTAGGG telomeric
Romina Burla +15 more
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eLife, 2021 Telomeres are nucleoprotein complexes at the ends of chromosomes and are indispensable for the protection and lengthening of terminal DNA. Despite the evolutionarily conserved roles of telomeres, the telomeric double-strand DNA (dsDNA)-binding proteins ...
Io Yamamoto +4 more
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Nature Communications, 2017 The human shelterin complex protects telomere ends from being recognized as damaged DNA sites and regulates telomere length in conjunction with telomerase.
Ci Ji Lim +3 more
doaj +1 more source
Characterization of t-loop formation by TRF2
Nucleus, 2020 T-loops are thought to hide telomeres from DNA damage signaling and DSB repair pathways. T-loop formation requires the shelterin component TRF2, which represses ATM signaling and NHEJ.
Leonid A. Timashev, Titia De Lange
doaj +1 more source
The Effect of Ethanol on Telomere Dynamics and Regulation in Human Cells
Cells, 2018 Telomeres (TLs) protect chromosome ends from chromosomal fusion and degradation, thus conferring genomic stability, and play crucial roles in cellular aging and disease.
Tomer Harpaz +6 more
doaj +1 more source
PLoS Genetics, 2019 Genomic rearrangements (gross chromosomal rearrangements, GCRs) threatens genome integrity and cause cell death or tumor formation. At the terminus of linear chromosomes, a telomere-binding protein complex, called shelterin, ensures chromosome stability ...
Hiroyuki Irie +5 more
doaj +1 more source
Structural insights into POT1-TPP1 interaction and POT1 C-terminal mutations in human cancer
Nature Communications, 2017 Human telomeres are protected by a specialized shelterin complex composed of six proteins. Here the authors structurally characterize the interaction between the POT1-TPP1 shelterin component and identify mutations associated with genome instability and ...
Cong Chen +19 more
doaj +1 more source
Mitoribosomal Deregulation Drives Senescence via TPP1-Mediated Telomere Deprotection
Cells, 2022 While mitochondrial bioenergetic deregulation has long been implicated in cellular senescence, its mechanistic involvement remains unclear. By leveraging diverse mitochondria-related gene expression profiles derived from two different cellular senescence
Seongki Min +6 more
doaj +1 more source
CST Meets Shelterin to Keep Telomeres in Check [PDF]
Molecular Cell, 2010 Telomere protection in budding yeast requires the heterotrimer named CST (for Cdc13-Stn1-Ten1). Recent data show that CST components are conserved and required for telomere stability in a wide range of eukaryotes, even those utilizing the shelterin complex to protect their telomeres.
Giraud-Panis, Marie-Josèphe +3 more
openaire +3 more sources
The role of shelterin in maintaining telomere integrity
Frontiers in Bioscience, 2012 The ends of eukaryotic chromosomes need to be protected from detection as DNA double strand breaks by the DNA damage response pathways. Failure to do so would have devastating consequences for genome integrity. Packaging of chromosome ends into protective structures called telomeres prevents checkpoint activation and DNA repair/recombination activities.
LONGHESE, MARIA PIA +3 more
openaire +3 more sources