Results 1 to 10 of about 4,347 (128)

Discovery of first-in-class inhibitors of the TRF1:TIN2 protein:protein interaction by fragment screening [PDF]

Scientific Reports
TRF1 is a subunit of the shelterin complex that binds to and protects the linear ends of chromosomes known as telomeres. Both genetic deletion and chemical inhibition of TRF1 have been shown to block the growth of lung carcinoma, glioblastoma, and renal ...
Giacomo Casale, Manjuan Liu, Yann-Vaï Le Bihan, Oviya Inian, Ellie Stammers, John Caldwell, Rob L. M. van Montfort, Ian Collins, Sebastian Guettler   +8 more
doaj   +3 more sources

Telomere damage-mediated senescence in alveolar epithelial type II cells but not in macrophages aggravates inflammation in acute lung injury [PDF]

Respiratory Research
Severity of acute lung injury (ALI) increases with age and is associated with enhanced inflammation in older individuals (inflamm-aging), characterized by increased expression of pro-inflammatory cytokines.
Christina Beatrix Hildebrand, Seyma Öztürk, Jia Li Ye, Dirk Wedekind, Ulrich A. Maus, Christian Bär, Christian Mühlfeld, Christina Brandenberger   +7 more
doaj   +2 more sources

TRF1 relies on fork reversal to prevent fragility at human telomeres [PDF]

Nature Communications
Telomeres pose challenges during replication, with converging forks unlikely to resolve issues. Depleting TRF1 results in fragile telomeres, yet its exact role in telomere replication remains unclear.
Mélina Vaurs, Eloïse Claude, Elia Zanella, Joana Rodrigues, Joe Nassour, Jan Karlseder, Claus M. Azzalin, Ylli Doksani, Anabelle Decottignies   +8 more
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Structural and functional impact of the POLD1 Ser605del variant in MDPL syndrome: insights from protein–protein interactions [PDF]

Human Genomics
Background Mandibular hypoplasia, Deafness, Progeroid features, and Lipodystrophy (MDPL) syndrome is a very rare genetic disorder linked to variants in the POLD1 gene, which encodes the catalytic subunit of DNA polymerase delta, a key enzyme involved in ...
Michela Murdocca, Isabella Romeo, Serena Maccaroni, Antonio Curcio, Gerardo Pepe, Manuela Helmer-Citterich, Stefano Alcaro, Giuseppe Novelli, Federica Sangiuolo   +8 more
doaj   +2 more sources

TRF1 and TRF2 form distinct shelterin subcomplexes at telomeres [PDF]

Cell Reports
Summary: The shelterin complex protects chromosome ends from aberrant DNA repair and regulates telomerase access to telomeres. Shelterin is composed of six proteins (TRF1, TRF2, TIN2, TPP1, POT1, and RAP1) that can assemble into various subcomplexes in ...
Tomáš Janovič, Gloria I. Perez, Greta Boelting, Jens C. Schmidt   +3 more
doaj   +2 more sources

A CPC-shelterin-BTR axis regulates mitotic telomere deprotection [PDF]

Nature Communications
Telomeres prevent ATM activation by sequestering chromosome termini within telomere loops (t-loops). Mitotic arrest promotes telomere linearity and a localized ATM-dependent telomere DNA damage response (DDR) through an unknown mechanism.
Diana Romero-Zamora, Samuel Rogers, Ronnie Ren Jie Low, Scott G. Page, Blake J. E. Lane, Shunya Kosaka, Andrew B. Robinson, Lucy French, Noa Lamm, Fuyuki Ishikawa, Makoto T. Hayashi, Anthony J. Cesare   +11 more
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Renal fibroblasts are involved in fibrogenic changes in kidney fibrosis associated with dysfunctional telomeres [PDF]

Experimental and Molecular Medicine
Tubulointerstitial fibrosis associated with chronic kidney disease (CKD) represents a global health care problem. We previously reported that short and dysfunctional telomeres lead to interstitial renal fibrosis; however, the cell-of-origin of kidney ...
Sarita Saraswati, Paula Martínez, Rosa Serrano, Diego Mejías, Osvaldo Graña-Castro, Ruth Álvarez Díaz, Maria A. Blasco   +6 more
doaj   +2 more sources

The truncated isoform of the receptor for hyaluronan-mediated motility (RHAMMΔ163) modulates shelterin and telomerase reverse transcriptase transcription affecting telomerase activity [PDF]

Frontiers in Aging
IntroductionThe receptor for hyaluronan-mediated motility (RHAMM), a centrosomal protein expressing in multiple isoforms, is implicated in telomerase-independent aging. However, its involvement in telomerase regulation is unproven.
Kaustuv Basu
doaj   +2 more sources

Comparison of telomere structure in eukaryotes [PDF]

Archives of Razi Institute
Telomeres are DNA-protein complexes located at eukaryotic chromosome ends. Broken chromosome ends fuse to each other; therefore, the role of telomeres is to prevent chromosome end fusion.
Sahar Mansoubi, Mohaddeseh Mohsenpour
doaj   +2 more sources

α-Terpineol Induces Shelterin Components TRF1 and TRF2 to Mitigate Senescence and Telomere Integrity Loss via A Telomerase-Independent Pathway [PDF]

Antioxidants
Cellular senescence is a hallmark of aging characterized by irreversible growth arrest and functional decline. Progressive telomeric DNA shortening in dividing somatic cells, programmed during development, leads to critically short telomeres that trigger
Marianna Kapetanou, Sophia Athanasopoulou, Andreas Goutas, Dimitra Makatsori, Varvara Trachana, Efstathios Gonos   +5 more
doaj   +2 more sources