Results 41 to 50 of about 4,397 (170)
Turkish Journal of Hematology, 2017 Objective: As evidence was shown that abnormal shortening of telomeres begins to accumulate in myelodysplastic syndrome (MDS) patients, this study was conducted to determine the relationship between the mRNA expression levels of telomere-binding proteins
Baoshan Liu +5 more
doaj +1 more source
Nature Communications, 2022 Telomere dysfunction induced by TRF1 depletion in fibroblasts, club and basal cells did not lead to interstitial lung fibrosis, underscoring alveolar type II cells as the relevant cell type in pulmonary fibrosis.
Sergio Piñeiro-Hermida +7 more
doaj +1 more source
Oleanolic acid inhibits mercury chloride induced-liver ferroptosis by regulating ROS/iron overload
Ecotoxicology and Environmental Safety, 2023 Mercury chloride can cause severe liver injury, which involves multiple mechanisms. Ferroptosis plays an important role in regulating the development and progression of liver pathology. Oleanolic acid (OA), a triterpenoid compound widely exists in fruits,
Chuan Ouyang +9 more
doaj +1 more source
TRF1 and TRF2 binding to telomeres is modulated by nucleosomal organization [PDF]
Nucleic Acids Research, 2015 The ends of eukaryotic chromosomes need to be protected from the activation of a DNA damage response that leads the cell to replicative senescence or apoptosis. In mammals, protection is accomplished by a six-factor complex named shelterin, which organizes the terminal TTAGGG repeats in a still ill-defined structure, the telomere.
GALATI, Alessandra +8 more
openaire +2 more sources
TRF1 uses a noncanonical function of TFIIH to promote telomere replication
Genes & Development, 2022 Telomeric DNA challenges the replisome and requires TRF1 for efficient duplication. TRF1 recruits the BLM helicase, but BLM loss does not explain the extensive telomere fragility, ATR signaling, and sister telomere associations (STAs) induced by TRF1 deletion.
Zhe Yang, Keshav Sharma, Titia de Lange
openaire +2 more sources
EMBO Molecular Medicine, 2015 Telomeres are considered anti‐cancer targets, as telomere maintenance above a minimum length is necessary for cancer growth. Telomerase abrogation in cancer‐prone mouse models, however, only decreased tumor growth after several mouse generations when ...
María García‐Beccaria +12 more
doaj +1 more source
A siRNA-based screen for genes involved in chromosome end protection. [PDF]
PLoS ONE, 2011 Telomeres are nucleoprotein complexes which protect the ends of linear chromosomes from detection as DNA damage and provide a sequence buffer against replication-associated shortening. In mammals, telomeres consist of repetitive DNA sequence (TTAGGG) and
Daniel H Lackner +2 more
doaj +1 more source
TRF1 Controls Telomere Length and Mitotic Fidelity in Epithelial Homeostasis [PDF]
Molecular and Cellular Biology, 2009 TRF1 is a component of the shelterin complex at mammalian telomeres; however, a role for TRF1 in telomere biology in the context of the organism is unclear. In this study, we generated mice with transgenic TRF1 expression targeted to epithelial tissues (K5TRF1 mice).
MUNOZ P +7 more
openaire +4 more sources
Mobile DNA, 2010 Background The ends of chromosomes, termed telomeres consist of repetitive DNA. The telomeric sequences shorten with cell division and, when telomeres are critically abbreviated, cells stop proliferating.
Yoshitake Kazutoshi +2 more
doaj +1 more source
Molecular Interplay of PARN and Telomerase: Tail Modifiers and Disease Implications
WIREs RNA, Volume 17, Issue 4, July/August 2026.Schematic representation of the molecular interplay between PARN, telomerase‐associated, and the involvement of p53 in regulating telomere maintenance and genome stability. The top panel shows how normal PARN levels are involved in regulating p53 levels and balanced telomerase activity through their regulatory interaction with TERC and TERRA, thus ...
Sujitha Felicitus +5 more
wiley +1 more source