Results 31 to 40 of about 4,397 (170)

Telomeric TERB1–TRF1 interaction is crucial for male meiosis [PDF]

Nature Structural & Molecular Biology, 2017
During meiotic prophase, the meiosis-specific telomere-binding protein TERB1 regulates chromosome movement required for homologous pairing and recombination by interacting with the telomeric shelterin subunit TRF1. Here, we report the crystal structure of the TRF1-binding motif of human TERB1 in complex with the TRFH domain of TRF1.
Juanjuan Long, Chenhui Huang, Yanyan Chen, Ying Zhang, Shaohua Shi, Ligang Wu, Yie Liu, Chengyu Liu, Jian Wu, Ming Lei   +9 more
openaire   +2 more sources

Safety of Whole-Body Abrogation of the TRF1 Shelterin Protein in Wild-Type and Cancer-Prone Mouse Models

iScience, 2019
Summary: Telomeres are considered potential anti-cancer targets. Most studies have focused on telomerase inhibition, but this strategy has largely failed in clinical trials.
Leire Bejarano, Jessica Louzame, Juán José Montero, Diego Megías, Juana M. Flores, Maria A. Blasco   +5 more
doaj   +1 more source

GNL3L stabilizes the TRF1 complex and promotes mitotic transition [PDF]

Journal of Cell Biology, 2009
Telomeric repeat binding factor 1 (TRF1) is a component of the multiprotein complex “shelterin,” which organizes the telomere into a high-order structure. TRF1 knockout embryos suffer from severe growth defects without apparent telomere dysfunction, suggesting an obligatory role for TRF1 in cell cycle control.
Zhu, Qubo, Meng, Lingjun, Hsu, Joseph K., Lin, Tao, Teishima, Jun, Tsai, Robert Y.L.   +5 more
openaire   +2 more sources

Plk1 Phosphorylation of TRF1 Is Essential for Its Binding to Telomeres [PDF]

Journal of Biological Chemistry, 2008
In a search for Polo-like kinase 1 (Plk1) interaction proteins, we have identified TRF1 (telomeric repeat binding factor 1) as a potential Plk1 target. In this communication we report further characterization of the interaction. We show that Plk1 associates with TRF1, and Plk1 phosphorylates TRF1 at Ser-435 in vivo. Moreover, Cdk1, serving as a priming
Zhao-Qiu, Wu, Xiaoming, Yang, Gregory, Weber, Xiaoqi, Liu   +3 more
openaire   +2 more sources

A Comprehensive Model for the Recognition of Human Telomeres by TRF1

Journal of Molecular Biology, 2013
Eukaryotic chromosomes are capped by telomeres, nucleoprotein complexes that prevent chromosome end-to-end fusions and control cell ageing. Two proteins in this complex, telomere repeat binding factors (TRF1 and TRF2), specifically recognise the double-stranded TTAGGG tandem repeat sequence. TRF1 is a homodimer with roles governing DNA architecture and
Garton, Michael, Laughton, Charles
openaire   +2 more sources

The protein network surrounding the human telomere repeat binding factors TRF1, TRF2, and POT1. [PDF]

PLoS ONE, 2010
Telomere integrity (including telomere length and capping) is critical in overall genomic stability. Telomere repeat binding factors and their associated proteins play vital roles in telomere length regulation and end protection.
Richard J Giannone, Hayes W McDonald, Gregory B Hurst, Rong-Fong Shen, Yisong Wang, Yie Liu   +5 more
doaj   +1 more source

Multiple cancer pathways regulate telomere protection

EMBO Molecular Medicine, 2019
Telomeres are considered as universal anti‐cancer targets, as telomere maintenance is essential to sustain indefinite cancer growth. Mutations in telomerase, the enzyme that maintains telomeres, are among the most frequently found in cancer. In addition,
Leire Bejarano, Giuseppe Bosso, Jessica Louzame, Rosa Serrano, Elena Gómez‐Casero, Jorge Martínez‐Torrecuadrada, Sonia Martínez, Carmen Blanco‐Aparicio, Joaquín Pastor, Maria A Blasco   +9 more
doaj   +1 more source

TRF1 interacts with XRCC4 and XLF at telomeres

The FASEB Journal, 2013
At telomeres, the shelterin complex is entrusted with a protective role against DNA repair mechanisms that could mistakenly recognize the natural ends of chromosomes as the product of a double strand break, and create telomeric end‐to‐end fusions that can drive genome instability and tumorigenesis.
Katherina Maria Alsina, Tatiana Nunez, Zamzam Abbas, Feven Bereket Berhe, Christian Le Timothy Le, Pramila Sen, Renu Jain, James Ramzi Jabbur, Albert Ribes‐Zamora   +8 more
openaire   +1 more source

AKTIP/Ft1, a New Shelterin-Interacting Factor Required for Telomere Maintenance. [PDF]

PLoS Genetics, 2015
Telomeres are nucleoprotein complexes that protect the ends of linear chromosomes from incomplete replication, degradation and detection as DNA breaks. Mammalian telomeres are protected by shelterin, a multiprotein complex that binds the TTAGGG telomeric
Romina Burla, Mariateresa Carcuro, Grazia D Raffa, Alessandra Galati, Domenico Raimondo, Angela Rizzo, Mattia La Torre, Emanuela Micheli, Laura Ciapponi, Giovanni Cenci, Enrico Cundari, Antonio Musio, Annamaria Biroccio, Stefano Cacchione, Maurizio Gatti, Isabella Saggio   +15 more
doaj   +1 more source

TERRA R-loops connect and protect sister telomeres in mitosis

Cell Reports, 2023
Summary: Resolution of cohesion between sister telomeres in human cells depends on TRF1-mediated recruitment of the polyADP-ribosyltransferase tankyrase to telomeres.
Samantha Sze, Amit Bhardwaj, Priyanka Fnu, Kameron Azarm, Rachel Mund, Katherine Ring, Susan Smith   +6 more
doaj   +1 more source