Results 51 to 60 of about 4,397 (170)
Brain and Behavior, Volume 16, Issue 5, May 2026.Hallmarks of brain aging regulated by microRNAs (miRNAs). This graphical abstract illustrates the central role of miRNAs in coordinating key biological processes associated with brain aging. miRNAs regulate multiple interconnected hallmarks, including genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis and impaired ...
Mustafa T. Ardah +7 more
wiley +1 more source
TRFH Domain Is Critical for TRF1-Mediated Telomere Stabilization
Cell Structure and Function, 2009 The telomeres are nucleoprotein complexes essential for maintaining the genomic integrity of linear chromosomes. Six telomere localizing proteins form a complex named "shelterin/telosome" to cooperatively regulate telomere length and protect chromosomal ends from DNA damage and repair responses. Mouse embryonic stem (ES) cells lacking TRF1, a shelterin
Okamoto, Keiji, Shinkai, Yoichi
openaire +3 more sources
Interdisciplinary Medicine, Volume 4, Issue 3, May 2026.SUMOylation, a dynamic post‐translational modification, acts as a master regulator at the heart of tumor malignancy. Our work delineates how the SUMOylation cycle—mediated by E1/E2/E3 enzymes and reversed by SENPs—orchestrates multiple hallmarks of cancer. The central pathway converges on three critical pathological axes: 1.
Yimao Wu +6 more
wiley +1 more source
TRF1 as a major contributor for telomeres' shortening in the context of obesity
Free Radical Biology and Medicine, 2018 Obesity is a prevalent multifactorial chronic disorder characterized by metabolic dysregulation. Sustained pro-oxidative mediators trigger harmful consequences that reflect at systemic level and contribute for the establishment of a premature senescent phenotype associated with macromolecular damage (DNA, protein, and lipids).
Lucas Kich Grun +15 more
openaire +3 more sources
Distinct TERB1 Domains Regulate Different Protein Interactions in Meiotic Telomere Movement
Cell Reports, 2017 Summary: Meiotic telomeres attach to the nuclear envelope (NE) and drive the chromosome movement required for the pairing of homologous chromosomes. The meiosis-specific telomere proteins TERB1, TERB2, and MAJIN are required to regulate these events, but
Jingjing Zhang +3 more
doaj +1 more source
Oxidative Stress‐Related Programmed Cell Death in Male Infertility: Focussing on Ferroptosis
Journal of Cellular and Molecular Medicine, Volume 30, Issue 10, May 2026.ABSTRACT Oxidative stress is a common occurrence in testicular cells of infertile men and is considered a significant cause of male reproductive dysfunction. The increase in reactive oxygen species (ROS) leads to impaired spermatogenesis by activating caspases and generating free radicals from mitochondria, resulting in DNA damage and cell death ...
Nafiseh Sanei‐Ataabadi +3 more
wiley +1 more source
Essential role of Pin1 in the regulation of TRF1 stability and telomere maintenance [PDF]
Nature Cell Biology, 2008 Telomeres are essential for maintaining cellular proliferative capacity and their loss has been implicated in ageing. A key regulator in telomere maintenance is the telomeric protein TRF1, which was also identified as Pin2 in a screen for Pin1. Pin1 is a unique prolyl isomerase that regulates protein conformation and function after phosphorylation ...
Tae Ho, Lee +10 more
openaire +2 more sources
Common Telomere Changes during In Vivo Reprogramming and Early Stages of Tumorigenesis
Stem Cell Reports, 2017 Reprogramming of differentiated cells into induced pluripotent stem cells has been recently achieved in vivo in mice. Telomeres are essential for chromosomal stability and determine organismal life span as well as cancer growth.
Rosa M. Marión +8 more
doaj +1 more source
Fungus Derived Indole‐3‐Acetic Acid Controls Developmental Conidial Death in Magnaporthe oryzae
Molecular Plant Pathology, Volume 27, Issue 4, April 2026.The severity of rice blast disease, caused by the fungus Magnaporthe oryzae, is influenced by IAA concentration and cell density. IAA regulates ferroptotic death of the developing conidia by affecting iron and lipid homeostasis. ABSTRACT Ferroptotic death of the developing conidia is important for pathogenicity of the blast fungus Magnaporthe oryzae ...
Yuming Ma +7 more
wiley +1 more source
Type 2 Diabetes From the Perspective of Telomere Biology
Endocrinology, Diabetes &Metabolism, Volume 9, Issue 2, March 2026.This graphical abstract illustrates the bidirectional relationship between the telomere/telomerase system and T2DM: telomere attrition contributes to pancreatic β‐cell dysfunction and insulin resistance through mechanisms such as oxidative stress and apoptosis, while T2DM‐related hyperglycemia and chronic inflammation further exacerbate telomere damage.
Hongye Cao +3 more
wiley +1 more source