Results 71 to 80 of about 4,397 (170)

A Novel Human Cellular System for Studying Normal Aging and for Anti‐Aging Discovery

Aging Cell, Volume 25, Issue 2, February 2026.
This study introduces a human cellular aging model using placental trophoblasts (hTSC‐STBs) that mimics key aging features like senescence and genomic instability. It aligns with human tissue aging and responds to anti‐aging treatments, offering a scalable platform to screen potential therapies and bridge lab findings to clinical applications ...
Zhen Feng, Cheuk Shuen Li, Haifeng Fu, Wenxin Jiang, Weiyu Zhang, Yingzhang Huang, Yunying Huang, Timothy Theodore Ka Ki Tam, Yang Li, Fang Liu, Liming Lu, Yin Lau Lee, William Shu Biu Yeung, Gordon Dougan, Pentao Liu   +14 more
wiley   +1 more source

Tethering of Telomeres to the Nuclear Envelope Is Mediated by SUN1-MAJIN and Possibly Promoted by SPDYA-CDK2 During Meiosis

Frontiers in Cell and Developmental Biology, 2020
During meiosis, telomeres attach to the nuclear envelope (NE) to promote homologous chromosome moving, pairing, synapsis, and recombination. The telomere-NE attachment is mediated by SUN1, TERB1-TERB2-MAJIN (TTM complex), and TRF1. The interaction of the
Guishuan Wang, Xiaolong Wu, Liwei Zhou, Sheng Gao, Damin Yun, Ajuan Liang, Fei Sun   +6 more
doaj   +1 more source

Liquid–Liquid Phase Separation in Major Hallmarks of Cancer

Cell Proliferation, Volume 59, Issue 2, February 2026.
Aberrant condensates formed through phase separation are involved in the dysregulation of various critical cellular processes, including genome stability, transcriptional regulation and signal transduction, thereby promoting malignant transformation and the acquisition of multiple cancer hallmarks.
Chen‐chen Xie, Ting Wang, Xin‐ran Liu, Yan Wang, Qin Dang, Tian Ding, Jia‐qi Xu, Xian‐jun Yu, Hai Lin, Xiao‐wu Xu, Yi Qin   +10 more
wiley   +1 more source

The role of matrix metalloproteinases and vascular grouth facrors in differentional diagnostic of prostate’s diseases

RUDN Journal of Medicine, 2014
The aim of this study was to determine of TRF1, MMP-7, FLT-1, KDR and VEGF mRNA expression levels obtained from prostate biopsies samples of patients with benign prostatic hyperplasia, prostate cancer and healthy men without prostate pathology.
V P Avdoshin, S A Pulbere, A V Loktev, A I Glukhov   +3 more
doaj  

Heterogeneity in the kinetics of nuclear proteins and trajectories of substructures associated with heterochromatin

Epigenetics & Chromatin, 2011
Background Protein exchange kinetics correlate with the level of chromatin condensation and, in many cases, with the level of transcription. We used fluorescence recovery after photobleaching (FRAP) to analyse the kinetics of 18 proteins and determine ...
Stixová Lenka, Bártová Eva, Matula Pavel, Daněk Ondřej, Legartová Soňa, Kozubek Stanislav   +5 more
doaj   +1 more source

Pulmonary Vascular Endothelial Cells in Lung Diseases: Mechanisms, Therapeutic Strategies, and Future Directions

Cell Proliferation, Volume 59, Issue 2, February 2026.
The pathogenic mechanisms of pulmonary vascular endothelial cells (VECs) in lung diseases and their multimodal therapeutic strategies. ABSTRACT Pulmonary vascular endothelial cells (VECs) are essential for the normal function of the lung, through maintaining vascular barrier integrity, regulating blood flow, and participating in inflammatory responses ...
Qianyue Liu, Hongshuai Zheng, Jing Liu, Ming Gao, Faquan Lin, Lin Liao   +5 more
wiley   +1 more source

Telomere associated gene expression as well as TERT protein level and telomerase activity are altered in the ovarian follicles of aged mice

Scientific Reports, 2021
Telomeres cap the ends of eukaryotic chromosomes to maintain genomic stability and integrity during an organism’s lifespan. The length of telomeres inevitably shortens due to DNA replication, genotoxic agents, and biological aging.
Esra Gozde Kosebent, Saffet Ozturk
doaj   +1 more source

PRKN‐Mediated Ubiquitin‐Proteasome Degradation of METTL3 Promotes Cellular Senescence

Aging Cell, Volume 25, Issue 1, January 2026.
Schematic diagram of model for PRKN mediate METTL3 proteasome degradation promoting cellular senescence. The left panel shows a high abundance of METTL3 expression in young cells. METTL3 mediates m6A modification on TRF2 and POT1 mRNA, leading to their high expression and maintaining telomere stability.
Liping Chen, Canfeng Zhang, Yuanlong Ge, Haoxian Zhou, Shenglong Yang, Wenjing Wei, Qinghua Zhou, Kaizhen Xiao, Guangyu Huang, Xiaocui Li, Jia Wang, Jinping Zheng, Ronghe Gu, Zhenyu Ju, Shu Wu   +14 more
wiley   +1 more source

Oxidative damage in telomeric DNA disrupts recognition by TRF1 and TRF2 [PDF]

Nucleic Acids Research, 2005
The ends of linear chromosomes are capped by protein-DNA complexes termed telomeres. Telomere repeat binding factors 1 and 2 (TRF1 and TRF2) bind specifically to duplex telomeric DNA and are critical components of functional telomeres. Consequences of telomere dysfunction include genomic instability, cellular apoptosis or senescence and organismal ...
Opresko, Patricia L, Fan, Jinshui, Danzy, Shamika, Wilson, David M, Bohr, Vilhelm A   +4 more
openaire   +4 more sources

Ovarian Aging: A Multifaceted Perspective on Mechanisms

Cell Proliferation, Volume 59, Issue 1, January 2026.
A mechanistic network of ovarian aging, highlighting mitochondrial dysfunction as a central hub interconnected with genetic, metabolic, and inflammatory pathways.
Xiaoqing Zhang, Xinyi Dong, Xue Zhang, Suying Yuan, Qiran Zhang, Zilu Guo, Xiaoxue Yang, Qionghua Wang, Tianlan Yang, Donghui Huang   +9 more
wiley   +1 more source