Results 21 to 30 of about 4,397 (170)
Human PinX1 Mediates TRF1 Accumulation in Nucleolus and Enhances TRF1 Binding to Telomeres
Journal of Molecular Biology, 2009 Human PinX1 (hPinX1) is known to interact with telomere repeat binding factor 1 (TRF1) and telomerase. Here, we report that hPinX1 regulates the nucleolar accumulation and telomeric association of TRF1. In HeLa, HA-hPinX1 was co-localized with fibrillarin, a nucleolar protein, in 51% of the transfected cells and was present in the nucleoplasm of the ...
Jeong Eun, Yoo +2 more
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TRF1 Mediates Mitotic Abnormalities Induced by Aurora-A Overexpression [PDF]
Cancer Research, 2010 Abstract Aurora-A, a conserved serine-threonine kinase, plays essential roles in mitosis. Aberrant upregulation of Aurora-A perturbs proper mitotic progression and results in a generation of multinucleated cells with centrosome amplification. The molecular mechanisms for these mitotic defects remain elusive.
Tomokazu, Ohishi +3 more
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PLoS ONE, 2015 Telomere binding factors viz. TRF1 and TRF2 are a part of sheltrin complex that are present exclusively at the ends of chromosomes. These factors play an important role in maintaining chromosomal integrity at the ends.
Deeksha Pal +4 more
doaj +1 more source
Telomere length modulation in human astroglial brain tumors. [PDF]
PLoS ONE, 2013 BACKGROUND: Telomeres alteration during carcinogenesis and tumor progression has been described in several cancer types. Telomeres length is stabilized by telomerase (h-TERT) and controlled by several proteins that protect telomere integrity, such as the
Domenico La Torre +9 more
doaj +1 more source
Dynamics of TRF1 organizing a single human telomere
Nucleic Acids Research, 2020 Abstract Chromosome stability is primarily determined by telomere length. TRF1 is the core subunit of shelterin that plays a critical role in telomere organization and replication. However, the dynamics of TRF1 in scenarios of telomere-processing activities remain elusive. Using single-molecule magnetic tweezers, we here investigated the
Xu Li +7 more
openaire +2 more sources
Distinct Roles of TRF1 in the Regulation of Telomere Structure and Lengthening [PDF]
Journal of Biological Chemistry, 2008 The telomere is a functional chromatin structure that consists of G-rich repetitive sequences and various associated proteins. Telomeres protect chromosomal ends from degradation, provide escape from the DNA damage response, and regulate telomere lengthening by telomerase.
Keiji, Okamoto +3 more
openaire +2 more sources
eLife, 2019 The mechanisms that regulate pluripotency are still largely unknown. Here, we show that Telomere Repeat Binding Factor 1 (TRF1), a component of the shelterin complex, regulates the genome-wide binding of polycomb and polycomb H3K27me3 repressive marks to
Rosa María Marión +7 more
doaj +1 more source
eLife, 2020 Telomeres are a significant challenge to DNA replication and are prone to replication stress and telomere fragility. The shelterin component TRF1 facilitates telomere replication but the molecular mechanism remains uncertain.
Rosa Maria Porreca +8 more
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Persistent telomere cohesion protects aged cells from premature senescence
Nature Communications, 2020 Telomere function is regulated by the telomere repeat binding proteins TRF1 and TRF2. Here the authors show that decreased levels of TRF1 proteins at shortened telomeres in aged human cells results in persistent telomere cohesion, protecting from ...
Kameron Azarm +3 more
doaj +1 more source
PLoS Genetics, 2020 TRF2 and TRF1 are a key component in shelterin complex that associates with telomeric DNA and protects chromosome ends. BRM is a core ATPase subunit of SWI/SNF chromatin remodeling complex.
Shu Wu +7 more
doaj +1 more source