Results 11 to 20 of about 4,397 (170)
AKT-dependent signaling of extracellular cues through telomeres impact on tumorigenesis.
PLoS Genetics, 2021 The telomere-bound shelterin complex is essential for chromosome-end protection and genomic stability. Little is known on the regulation of shelterin components by extracellular signals including developmental and environmental cues.
Raúl Sánchez-Vázquez +2 more
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Frontiers in Cell and Developmental Biology, 2021 In eukaryotic chromosomes, the centromere and telomere are two specialized structures that are essential for chromosome stability and segregation. Although centromeres and telomeres often are located in close proximity to form telocentric chromosomes in ...
Hyuk-Joon Jeon, Jeong Su Oh
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Importance of TRF1 for Functional Telomere Structure [PDF]
Journal of Biological Chemistry, 2004 Telomeres are comprised of telomeric DNA sequences and associated binding molecules. Their structure functions to protect the ends of linear chromosomes and ensure chromosomal stability. One of the mammalian telomere-binding factors, TRF1, localizes telomeres by binding to double-stranded telomeric DNA arrays.
Iwano, Tomohiko +3 more
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Control of Human Telomere Length by TRF1 and TRF2 [PDF]
Molecular and Cellular Biology, 2000 Telomere length in human cells is controlled by a homeostasis mechanism that involves telomerase and the negative regulator of telomere length, TRF1 (TTAGGG repeat binding factor 1). Here we report that TRF2, a TRF1-related protein previously implicated in protection of chromosome ends, is a second negative regulator of telomere length.
A, Smogorzewska +6 more
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Communications Biology, 2023 The poly (ADP-ribose) polymerase (PARP1) interacts with the telomere factor TRF1 and loss of PARP1 results in telomere fragility and impairment of helicases -TRF1 complex assembly.
C. Maresca +12 more
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Structural Basis of Selective Ubiquitination of TRF1 by SCFFbx4 [PDF]
Developmental Cell, 2010 TRF1 is a critical regulator of telomere length. As such, TRF1 levels are regulated by ubiquitin-dependent proteolysis via an SCF E3 ligase where Fbx4 contributes to substrate specification. Here, we report the crystal structure of the Fbx4-TRF1 complex at 2.4 A resolution.
Zeng, Zhixiong +7 more
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PinX1 Localizes to Telomeres and Stabilizes TRF1 at Mitosis [PDF]
Molecular and Cellular Biology, 2012 Human telomeres are DNA-protein complexes that cap and protect the ends of chromosomes. The protein PinX1 associates with telomeres through an interaction with the resident double-stranded telomere-binding protein TRF1. PinX1 also binds to and inhibits telomerase, the enzyme responsible for complete replication of telomeric DNA.
Tohru, Yonekawa +2 more
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Mouse HP1γ regulates TRF1 expression and telomere stability
Life Sciences, 2023 Telomeric repeat-containing RNAs are long non-coding RNAs generated from the telomeres. TERRAs are essential for the establishment of heterochromatin marks at telomeres, which serve for the binding of members of the heterochromatin protein 1 (HP1) protein family of epigenetic modifiers involved with chromatin compaction and gene silencing.
Stylianakis, Emmanouil +7 more
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Cells, 2022 Telomere shortening is well known to be associated with ageing. Age is the most decisive risk factor for age-related macular degeneration (AMD) development. The older the individual, the higher the AMD risk.
Alvita Vilkeviciute +6 more
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Stem Cell Research, 2023 Telomeric repeat binding factor 1 (TRF1) plays an essential role in maintaining telomere length. Here, we established TRF1-knockout human pluripotent stem cells (hPSCs; hTRF1-KO) using the CRISPR/Cas9 technology.
Onju Ham +3 more
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