Results 51 to 60 of about 4,964 (165)
BMC Veterinary Research, 2023 Background Motion quality is a critical property for essential functions. Several endogenous and exogenous factors are involved in sperm motility. Here, we measured the relative telomere length and evaluated the gene expression of its binding-proteins ...
Hossein Hassanpour +5 more
doaj +1 more source
Animals, 2020 Omega-3 fatty acids are health-promoting nutrients that contribute to the amelioration of age-related diseases. Recent studies have reported the role of these fatty acids in the aging process, explicitly impacting telomere biology.
Magdalena Ogłuszka +5 more
doaj +1 more source
The aging paradox of Cushing's syndrome: Stress without clear senescence?
Journal of Neuroendocrinology, Volume 38, Issue 6, June 2026.Abstract Cushing's syndrome (CS), characterized by chronic endogenous hypercortisolism and disruption of the normal circadian cortisol rhythm, represents a unique human model for investigating the interplay between stress endocrinology and biological aging.
Israel Nunes Silveira +1 more
wiley +1 more source
Telomere maintenance and the DNA damage response: a paradoxical alliance
Frontiers in Cell and Developmental BiologyTelomeres are the protective caps at the ends of linear chromosomes of eukaryotic organisms. Telomere binding proteins, including the six components of the complex known as shelterin, mediate the protective function of telomeres.
Ashley Harman, Tracy M. Bryan
doaj +1 more source
Brain and Behavior, Volume 16, Issue 5, May 2026.Hallmarks of brain aging regulated by microRNAs (miRNAs). This graphical abstract illustrates the central role of miRNAs in coordinating key biological processes associated with brain aging. miRNAs regulate multiple interconnected hallmarks, including genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis and impaired ...
Mustafa T. Ardah +7 more
wiley +1 more source
The role of senescence, telomere dysfunction and shelterin in vascular aging [PDF]
Microcirculation, 2018 AbstractIn the United States and other westernized nations, CVDs are the leading cause of death in adults over 65 years of age. Large artery stiffness and endothelial dysfunction are increased with age and age‐associated arterial dysfunction is an important antecedent of CVDs.
Yu Liu +2 more
openaire +2 more sources
Multiomics Research Strategies in Cancer: A Growing and Innovative Field
MedComm, Volume 7, Issue 4, April 2026.This review highlights multiomics strategies in cancer research, focusing on integration methods from genomics to microbiomics. Using colorectal cancer as a key example, it discusses biomarker discovery, data integration via deep learning, and the roles of single‐cell and spatial omics.
Zhenhua Du +8 more
wiley +1 more source
Type 2 Diabetes From the Perspective of Telomere Biology
Endocrinology, Diabetes &Metabolism, Volume 9, Issue 2, March 2026.This graphical abstract illustrates the bidirectional relationship between the telomere/telomerase system and T2DM: telomere attrition contributes to pancreatic β‐cell dysfunction and insulin resistance through mechanisms such as oxidative stress and apoptosis, while T2DM‐related hyperglycemia and chronic inflammation further exacerbate telomere damage.
Hongye Cao +3 more
wiley +1 more source
MedComm – Oncology, Volume 5, Issue 1, March 2026.Ageing acts as a double‐edged sword in cancer. In the elderly, open chromatin, immunosenescence, and chronic inflammation drive SASP (IL‐6, MMPs), MDSC accumulation and T‐cell suppression, fostering tumor‐promoting microenvironments and limited therapeutic benefit.
Qi Wang +7 more
wiley +1 more source
Revisiting Telomere Shortening in Cancer
Cells, 2019 Telomeres, the protective structures of chromosome ends are gradually shortened by each cell division, eventually leading to senescence or apoptosis.
Keiji Okamoto, Hiroyuki Seimiya
doaj +1 more source