Results 71 to 80 of about 4,964 (165)

The WHO Classification of Genetic Tumour Syndromes: Considerations for histopathology

Histopathology, Volume 88, Issue 7, Page 1291-1294, June 2026.
Ian A Cree, Mark J Arends, Joseph D Khoury, Erika RE Denton, Anthony J Gill, Alexander J Lazar, Ian M Frayling, Stefan M Pfister, Mark A Rubin, Katia RM Leite, Raymond Dalgleish, Elspeth A Bruford, Sharon Plon, Ada Hamosh, Michael Francis Walsh, Gabrielle Goldman‐Lévy, Harshima Wijesinghe, William D Foulkes, Dilani Lokuhetty   +18 more
wiley   +1 more source

Liquid–Liquid Phase Separation in Major Hallmarks of Cancer

Cell Proliferation, Volume 59, Issue 2, February 2026.
Aberrant condensates formed through phase separation are involved in the dysregulation of various critical cellular processes, including genome stability, transcriptional regulation and signal transduction, thereby promoting malignant transformation and the acquisition of multiple cancer hallmarks.
Chen‐chen Xie, Ting Wang, Xin‐ran Liu, Yan Wang, Qin Dang, Tian Ding, Jia‐qi Xu, Xian‐jun Yu, Hai Lin, Xiao‐wu Xu, Yi Qin   +10 more
wiley   +1 more source

Using an Unbiased Coexpression Network to Reveal Cross‐Talking Pathways of Phosphoinositide‐3‐Kinase Regulatory Subunit 1 in Skin Aging and Rejuvenation

The FASEB Journal, Volume 40, Issue 2, 31 January 2026.
Mechanistic pathways of PIK3R1 in skin aging and rejuvenation were analyzed by bioinformatics approach and Gene Expression Omnibus database. Compared with young skin, PIK3R1 was differentially expressed in aged and IPL rejuvenated skin. Coexpression and network analyses revealed that PIK3R1 jointly participated in skin aging and rejuvenation via PI3K ...
Zhike Zhou, Sha Sha, Xiangnan Zhou, Chundi He, Ting Xiao, Yan Wu, Fenqin Chen, Le Qu, Hong‐Duo Chen   +8 more
wiley   +1 more source

Identification of human TERT elements necessary for telomerase recruitment to telomeres

eLife, 2014
Human chromosomes terminate in telomeres, repetitive DNA sequences bound by the shelterin complex. Shelterin protects chromosome ends, prevents recognition by the DNA damage machinery, and recruits telomerase. A patch of amino acids, termed the TEL-patch,
Jens C Schmidt, Andrew B Dalby, Thomas R Cech   +2 more
doaj   +1 more source

POT1-TPP1 telomere length regulation and disease

Computational and Structural Biotechnology Journal, 2020
Telomeres are DNA repeats at the ends of linear chromosomes and are replicated by telomerase, a ribonucleoprotein reverse transcriptase. Telomere length regulation and chromosome end capping are essential for genome stability and are mediated primarily ...
Tomas Aramburu, Sarah Plucinsky, Emmanuel Skordalakes   +2 more
doaj   +1 more source

Emerging Therapeutic Strategies in Anti‐Aging Medicine: A Comprehensive Review

Medicine Bulletin, Volume 2, Issue 1, Page 94-123, January 2026.
ABSTRACT Aging is orchestrated by interconnected hallmarks such as genomic instability, mitochondrial dysfunction, cellular senescence, and disrupted intercellular communication, which collectively drive chronic disease progression. Recent advances have expanded therapeutic opportunities to include pharmacological agents, gene and epigenome editing ...
Yundong Peng, Rui Li, Huan Li, Jun Zhou, Xuanshi Liu, Guilherme Valente, Tatiana de Campos Melo, Sifan Chen, Lei Gu   +8 more
wiley   +1 more source

PRKN‐Mediated Ubiquitin‐Proteasome Degradation of METTL3 Promotes Cellular Senescence

Aging Cell, Volume 25, Issue 1, January 2026.
Schematic diagram of model for PRKN mediate METTL3 proteasome degradation promoting cellular senescence. The left panel shows a high abundance of METTL3 expression in young cells. METTL3 mediates m6A modification on TRF2 and POT1 mRNA, leading to their high expression and maintaining telomere stability.
Liping Chen, Canfeng Zhang, Yuanlong Ge, Haoxian Zhou, Shenglong Yang, Wenjing Wei, Qinghua Zhou, Kaizhen Xiao, Guangyu Huang, Xiaocui Li, Jia Wang, Jinping Zheng, Ronghe Gu, Zhenyu Ju, Shu Wu   +14 more
wiley   +1 more source

α-Terpineol Induces Shelterin Components TRF1 and TRF2 to Mitigate Senescence and Telomere Integrity Loss via A Telomerase-Independent Pathway

Antioxidants
Cellular senescence is a hallmark of aging characterized by irreversible growth arrest and functional decline. Progressive telomeric DNA shortening in dividing somatic cells, programmed during development, leads to critically short telomeres that trigger
Marianna Kapetanou, Sophia Athanasopoulou, Andreas Goutas, Dimitra Makatsori, Varvara Trachana, Efstathios Gonos   +5 more
doaj   +1 more source

Loss of telomere protection: consequences and opportunities.

Frontiers in Oncology, 2013
Telomeres are repetitive sequences at the natural ends of linear eukaryotic chromosomes that protect these from recognition as chromosome breaks. Their ability to do so critically depends on the binding of sufficient quantities of functional shelterin, a
Jacqueline Johanna Leonarda Jacobs
doaj   +1 more source

Ubiquitin C-terminal hydrolase isozyme L1 is associated with shelterin complex at interstitial telomeric sites

Epigenetics & Chromatin, 2017
Background Ubiquitin C-terminal hydrolase isozyme L1 (UCHL1) is primarily expressed in neuronal cells and neuroendocrine cells and has been associated with various diseases, including many cancers.
Aleksandar Ilic, Sumin Lu, Vikram Bhatia, Farhana Begum, Thomas Klonisch, Prasoon Agarwal, Wayne Xu, James R. Davie   +7 more
doaj   +1 more source