Results 61 to 70 of about 4,964 (165)

Multifacet Roles of Cellular Senescence in Cancer: Mechanisms and Therapeutic Implications

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Cellular senescence shapes tumor progression through both antitumor and protumor mechanisms. Senescence triggered by telomere shortening restricts malignant transformation and limits tumor cell proliferation, while the senescence‐associated secretory phenotype (SASP) secretion enhances antitumor immunity by activating cytotoxic T cells.
Huajie Mao, Wanning Liu, Yuanyuan Su, Yuxuan Ma, Xiaodi Zhao, Yuanyuan Lu   +5 more
wiley   +1 more source

ZNF524 directly interacts with telomeric DNA and supports telomere integrity

Nature Communications, 2023
Telomeres are nucleoprotein structures at the ends of linear chromosomes. In humans, they consist of TTAGGG repeats, which are bound by dedicated proteins such as the shelterin complex. This complex blocks unwanted DNA damage repair at telomeres, e.g. by
Hanna Braun, Ziyan Xu, Fiona Chang, Nikenza Viceconte, Grishma Rane, Michal Levin, Liudmyla Lototska, Franziska Roth, Alexia Hillairet, Albert Fradera-Sola, Vartika Khanchandani, Zi Wayne Sin, Wai Khang Yong, Oliver Dreesen, Yang Yang, Yunyu Shi, Fudong Li, Falk Butter, Dennis Kappei   +18 more
doaj   +1 more source

Removal of Shelterin Reveals the Telomere End-Protection Problem [PDF]

Science, 2012
Not Broken Until Repaired Humans, and indeed most eukaryotes, have linear chromosomes with two DNA ends, known as telomeres. Cells have evolved sophisticated systems to repair broken chromosomes, which specifically recognize DNA ends as damage.
Agnel, Sfeir, Titia, de Lange
openaire   +2 more sources

Clinical, genetic, and familial features of POT1 tumor predisposition syndrome

Cancer, Volume 132, Issue 4, 15 February 2026.
Abstract Background Protection of telomere 1 (POT1) tumor predisposition syndrome (POT1‐TPD) is a hereditary leukemia syndrome that is identified in ∼5% of patients with chronic lymphocytic leukemia (CLL) and is characterized by a predisposition to other cancers, including gliomas, melanomas, and angiosarcomas.
Courtney D. DiNardo, Jennifer Croden, Hiam M. Abdel‐Salam, Tapan Kadia, Matteo Molica, Alexandre Bazinet, Prithviraj Bose, Abhishek Maiti, Fadi Haddad, Jan Burger, Hagop Kantarjian, William Wierda, Nitin Jain, Alessandra Ferrajoli   +13 more
wiley   +1 more source

Unravelling the Intricacies of Telomere Replication: A Molecular Conundrum

Canadian Journal for the Academic Mind
Telomeres are specialized structures at the ends of linear chromosomes that protect them from degradation and fusion. It’s replication is a complex process that involves both DNA polymerases and a specialized enzyme called telomerase which is a ...
Neelabh Datta
doaj   +1 more source

Impaired telomere integrity and rRNA biogenesis in PARN‐deficient patients and knock‐out models

EMBO Molecular Medicine, 2019
PARN, poly(A)‐specific ribonuclease, regulates the turnover of mRNAs and the maturation and stabilization of the hTR RNA component of telomerase. Biallelic PARN mutations were associated with Høyeraal–Hreidarsson (HH) syndrome, a rare telomere biology ...
Maname Benyelles, Harikleia Episkopou, Marie‐Françoise O'Donohue, Laëtitia Kermasson, Pierre Frange, Florian Poulain, Fatma Burcu Belen, Meltem Polat, Christine Bole‐Feysot, Francina Langa‐Vives, Pierre‐Emmanuel Gleizes, Jean‐Pierre de Villartay, Isabelle Callebaut, Anabelle Decottignies, Patrick Revy   +14 more
doaj   +1 more source

High‐fat diet induced obesity and age influence the telomere shelterin complex and telomerase gene expression in mouse adipose tissue

Physiological Reports, 2020
Obesity and aging are linked to inflammation and increased risk of chronic disease. Telomeres are the endcaps of chromosomes that are regulated by telomerase, the enzyme that elongates telomeres, as well as a protein complex known as shelterin.
Samuel I. Bloom, Andrei Tuluca, Stephen J. Ives, Thomas H. Reynolds   +3 more
doaj   +1 more source

A Novel Human Cellular System for Studying Normal Aging and for Anti‐Aging Discovery

Aging Cell, Volume 25, Issue 2, February 2026.
This study introduces a human cellular aging model using placental trophoblasts (hTSC‐STBs) that mimics key aging features like senescence and genomic instability. It aligns with human tissue aging and responds to anti‐aging treatments, offering a scalable platform to screen potential therapies and bridge lab findings to clinical applications ...
Zhen Feng, Cheuk Shuen Li, Haifeng Fu, Wenxin Jiang, Weiyu Zhang, Yingzhang Huang, Yunying Huang, Timothy Theodore Ka Ki Tam, Yang Li, Fang Liu, Liming Lu, Yin Lau Lee, William Shu Biu Yeung, Gordon Dougan, Pentao Liu   +14 more
wiley   +1 more source

Therapeutic inhibition of TRF1 impairs the growth of p53‐deficient K‐RasG12V‐induced lung cancer by induction of telomeric DNA damage

EMBO Molecular Medicine, 2015
Telomeres are considered anti‐cancer targets, as telomere maintenance above a minimum length is necessary for cancer growth. Telomerase abrogation in cancer‐prone mouse models, however, only decreased tumor growth after several mouse generations when ...
María García‐Beccaria, Paula Martínez, Marinela Méndez‐Pertuz, Sonia Martínez, Carmen Blanco‐Aparicio, Marta Cañamero, Francisca Mulero, Chiara Ambrogio, Juana M Flores, Diego Megias, Mariano Barbacid, Joaquín Pastor, Maria A Blasco   +12 more
doaj   +1 more source

Shelterin protein keeps telomeres on edge [PDF]

Journal of Cell Biology, 2013
![Figure][1] Telomeres (bright spots) are concentrated at the edges of nuclei in a nematode embryo. A member of the shelterin complex helps moor telomeres at the nuclear periphery in worms, [Ferreira et al.][2] reveal.
openaire   +1 more source