Results 81 to 90 of about 4,964 (165)
Biochemical and structural analysis of shelterin subcomplexes [PDF]
, 2020 Doctor of Philosophy (SBS)
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FASEB BioAdvancesInhaling xenobiotics, such as tobacco smoke is a major risk factor for pulmonary diseases, e.g., COPD/emphysema, interstitial lung disease, and pre‐invasive diseases.
Thivanka Muthumalage +2 more
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PLoS Genetics, 2018 Telomere-binding proteins constituting the shelterin complex have been studied primarily for telomeric functions. However, mounting evidence shows non-telomeric binding and gene regulation by shelterin factors.
Ananda Kishore Mukherjee +11 more
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Retrovirology, 2005 Background The functional state of human telomeres is controlled by telomerase and by a protein complex named shelterin, including the telomeric DNA-binding proteins TRF1, TRF2 and Pot1 involved in telomere capping functions.
Gilson Eric +6 more
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Novel Mutation of the TINF2 Gene in a Patient with Dyskeratosis Congenita
Case Reports in Dermatology, 2015 Dyskeratosis congenita (DKC) is a rare inherited disease that is characterized by abnormal skin pigmentation, nail dystrophy and mucosal leukoplakia. DKC is caused by an abnormality in a component of the telomerase and shelterin complexes.
Benjaporn Panichareon +5 more
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Shelterin: the protein complex that shapes and safeguards human telomeres [PDF]
Genes & Development, 2005 Added by telomerase, arrays of TTAGGG repeats specify the ends of human chromosomes. A complex formed by six telomere-specific proteins associates with this sequence and protects chromosome ends. By analogy to other chromosomal protein complexes such as condensin and cohesin, I will refer to this complex as shelterin.
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Telomere Dysfunction Induced Foci (TIF) Analysis
Bio-Protocol, 2015 Telomerase maintains telomeric DNA in eukaryotes during early developments, ~90% of cancer cells and some proliferative stem like cells. Telomeric repeats at the end of chromosomes are associated with the shelterin complex. This complex consists of TRF1,
ilgen Mender, Jerry Shay
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The Shelterin TIN2 Subunit Mediates Recruitment of Telomerase to Telomeres
PLOS Genetics, 2015 Dyskeratosis Congenita (DC) is a heritable multi-system disorder caused by abnormally short telomeres. Clinically diagnosed by the mucocutaneous symptoms, DC patients are at high risk for bone marrow failure, pulmonary fibrosis, and multiple types of cancers.
Frank, Amanda K +5 more
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How Shelterin Solves the Telomere End-Protection Problem [PDF]
Cold Spring Harbor Symposia on Quantitative Biology, 2010 The symphony of the human genome concludes with a long Gregorian chant of TTAGGG repeats. This monotonous coda represents one of the most complex problems in chromosome biology: the question of how cells distinguish their natural chromosome ends from double-strand breaks elsewhere in the genome.
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Multiple cancer pathways regulate telomere protection
EMBO Molecular Medicine, 2019 Telomeres are considered as universal anti‐cancer targets, as telomere maintenance is essential to sustain indefinite cancer growth. Mutations in telomerase, the enzyme that maintains telomeres, are among the most frequently found in cancer. In addition,
Leire Bejarano +9 more
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