Triazole analogues as potential pharmacological agents: a brief review
Future Journal of Pharmaceutical Sciences, 2021 Background A large number of studies have recently reported that, because of their significant biological and pharmacological properties, heterocyclic compounds and their derivatives have attracted a strong interest in medicinal chemistry.
Sachin Kumar +2 more
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Triazole-Resistance in Environmental Aspergillus fumigatus in Latin American and African Countries
Journal of Fungi, 2021 Triazole-resistance has been reported increasingly in Aspergillus fumigatus. An international expert team proposed to avoid triazole monotherapy for the initial treatment of invasive aspergillosis in regions with >10% environmental-resistance, but this ...
Agustin Resendiz-Sharpe +9 more
doaj +2 more sources
Mutations in
mBio, 2019 Aspergillus fumigatus is the predominant pathogen of invasive aspergillosis, a disease state credited with over 200,000 life-threatening infections each year.
Jeffrey M. Rybak +6 more
doaj +2 more sources
Synthesis methods of 1,2,3-/1,2,4-triazoles: A review
Frontiers in Chemistry, 2022 Triazole, comprising three nitrogen atoms and two carbon atoms, is divided into two isomers 1,2,3-triazole and 1,2,4-triazole. Compounds containing a triazole are one of the significant heterocycles that exhibit broad biological activities, such as ...
Jinlian Dai +3 more
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Fluorescent Analogues of FRH Peptide: Cu(II) Binding and Interactions with ds-DNA/RNA
Chemosensors, 2022 Four novel peptidoids, derived from the Phe-Arg-His (FRH) peptide motif, were prepared by replacing the histidine heterocycle with triazole and consequent triazole-fluorophore (coumarin) extension and also replacing arginine with less voluminous lysine ...
Marta Košćak +3 more
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Pharmacotherapy, 2023 Triazole antifungals (i.e., fluconazole, itraconazole, voriconazole, posaconazole, and isavuconazole) are commonly used in clinical practice to prevent or treat invasive fungal infections.
E. McCreary +9 more
semanticscholar +1 more source
An Overview of 1,2,3-triazole-Containing Hybrids and Their Potential Anticholinesterase Activities
Pharmaceuticals, 2023 Acetylcholine (ACh) neurotransmitter of the cholinergic system in the brain is involved in learning, memory, stress responses, and cognitive functioning.
S. Khan +4 more
semanticscholar +1 more source
Enantiomer stability of atropisomeric 1,5-disubstituted 1,2,3-triazoles
Tetrahedron Chem, 2022 The synthesis and characterisation of axially chiral atropisomeric 1,5-disubstituted 1,2,3-triazoles is reported. Molecules designed to display restricted rotation about 1,2,3-triazole N-1-aryl or 1,2,3-triazole C-5-aryl bonds were investigated by ...
Fernanda Meloni +6 more
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Benzimidazole-Triazole Hybrids as Antimicrobial and Antiviral Agents: A Systematic Review
Antibiotics, 2023 Bacterial infections have attracted the attention of researchers in recent decades, especially due to the special problems they have faced, such as their increasing diversity and resistance to antibiotic treatment.
M. Marinescu
semanticscholar +1 more source
Genome-Wide Association Analysis for Triazole Resistance in Aspergillus fumigatus
Pathogens, 2021 Aspergillus fumigatus is a ubiquitous fungus and the main agent of aspergillosis, a common fungal infection in the immunocompromised population. Triazoles such as itraconazole and voriconazole are the common first-line drugs for treating aspergillosis ...
Yuying Fan +4 more
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