Results 211 to 220 of about 80,033 (290)

A New Recruitable E3 Ligase UHRF1 Supporting Targeted Protein Degradation: A Minimal Azide as a Recruitment Ligand

Advanced Science, Volume 13, Issue 62, 9 November 2026.
Targeted protein degradation is often limited by the scarcity of usable E3 ligases. Herein, we report the first small‐molecule GPX4 degraders that incorporate either electrophilic warheads or a minimal azide group as an E3 recruitment ligand. The azide‐based degrader DK‐5070 effectively drives potent GPX4 degradation; mechanistic studies reveal that ...
Zehong Lin, Kang Duan, Rui Wan, Tao Jiang, Jinzhe Wei, Miao Sun, Mariia A. Skryl'nikova, Maxim A. Gureev, Zhi‐Min Zhang, Zhang Zhang, Ke Ding, Nan Ma, Tongzheng Liu, Yi Tan, Zhengqiu Li   +14 more
wiley   +1 more source

Coordination-guided design of triazole-based Cu(ii) and Pt(iv) complexes: synthesis, characterization, theoretical studies, molecular docking and anticancer activity. [PDF]

RSC Adv
Naji HK, Al Hassani RAM, Balakit AA, Obies M, Saleh BA, Jabir MS.   +5 more
europepmc   +1 more source

The Elements of Chiral Brønsted Acids for Stereoselective Transformations

Asian Journal of Organic Chemistry, Volume 15, Issue 11, November 2026.
This review focuses on chiral Brønsted acids (CBAs), examining how each structural component influences the stereochemical outcome. For each element—scaffold, acidic site, substituents—we identify advantages and disadvantages relevant to the catalyst design and selection.
Diego A. Cruz‐Aguilar, Margarita Cantú‐Reyes, David A. Contreras‐Cruz, Eddy I. Jiménez   +3 more
wiley   +1 more source

Exploring the Anticancer Potential of Plant, Marine, and Synthetic Glycosides: A Comprehensive Review. [PDF]

Biomolecules
Jabeen T, Akram S, Ahmad M, Al-Hussain SA, Zaki MEA.   +4 more
europepmc   +1 more source

Real‐Time Neurochemical Sensing in Zebrafish: Electrochemical and Fluorescent Approaches

Analysis &Sensing, Volume 6, Issue 6, November 2026.
The use of zebrafish has emerged as a powerful approach for real‐time neurochemical measurements. This review highlights recent advances in electrochemical and fluorescent sensing strategies that enable dynamic measurements in live preparations of this complex vertebrate. These complementary approaches provide new insights into neurochemical signaling,
Piyanka Hettiarachchi, Jacob T. Theismann, Michael A. Johnson   +2 more
wiley   +1 more source

Design, synthesis, molecular modelling and biological evaluation of oxiconazole-based 1,2,3-triazoles as dually acting antifungal and antitumor agents. [PDF]

Sci Rep
Ismail AE, Ashmawy MI, Shehat MG, Al-Seqely MA, Badr MH, Rostom SAF.   +5 more
europepmc   +1 more source

Exploring the Antitubercular, Antimicrobial Potency, ADME-T Calculations and Docking Studies of 1,2,4-Triazole-Bearing Benzimidazoles. [PDF]

Chem Biodivers
Shaik KM, Pandurangan K, Bhoomandla S, Mendam K, Ullapu PR.   +4 more
europepmc   +1 more source

A Regioselective Approach to Accessing Trisubstituted Pyrrolo[2,3-d][1,2,3]triazoles via an Orthogonal Protection Strategy. [PDF]

Molecules
Brugemann K, Garnier S, Vercouillie J, Routier S, Buron F.   +4 more
europepmc   +1 more source

Synthesis and Broad-Spectrum Antiviral Evaluation of Novel 1,2,3-Triazole-Quinoline Derivatives Targeting SARS-CoV-2, Influenza, DENV-2, and CHIKV. [PDF]

Viruses
de Carvalho AS, Fintelman-Rodrigues N, de Camargo VTD, Silva-Trujillo L, de Freitas CS, Graciano IA, de Souza AS, de Assis CB, Chaves OA, da Silva FC, Ferreira VF, Souza TML.   +11 more
europepmc   +1 more source

In Vitro and In Silico Evaluation of the Antitumor Potential of New Benzotriazole-1,2,4-Triazole Hybrids. [PDF]

Pharmaceuticals (Basel)
Mardale G, Dumitrașcu V, Pop R, Dumitru C, Muntean D, Mioc M, Mioc A, Mara BI, Balan-Porcarasu M, Budu O, Negrea-Ghiulai R, Șoica C.   +11 more
europepmc   +1 more source