Results 251 to 260 of about 123,319 (291)

Targeting Tumor Dormancy and Recurrence: Molecular Mechanisms and Peptide Therapeutic Delivery

MedComm – Oncology, Volume 5, Issue 1, March 2026.
This review summarizes the molecular mechanisms that regulate tumor dormancy and its role in cancer recurrence, with emphasis on immune evasion, extracellular matrix remodeling, metabolic regulation and angiogenic switching. It further discusses emerging peptide–based therapeutic strategies aimed at detecting, modulating, and eliminating dormant tumor ...
Abdur Raheem Aleem, Atif Ali, Wajid Ali, Yuying Cheng, Zhibin Yan, Chaoyi Xia, Chenguang Liu, Caiyun Fu, Yiren Hu, Xi Wang   +9 more
wiley   +1 more source

Synthesis, Antibacterial Properties and Molecular Docking Studies of Nitrogen Substituted 9-(((4X-But-2-ynyloxy)methyl)-1,2,3-triazolyl)-Cinchona Alkaloid Conjugates. [PDF]

Molecules
Mukusheva GK, Toigambekova NN, Savelyev VA, Khlebnikov AI, Burova LG, Afanaseva SD, Nurkenov OA, Kishkentayeva AS, Olzhabayeva AS, Gatilov YV, Seidakhmetova RB, Evstropov AN, Shults EE.   +12 more
europepmc   +1 more source

Making Blank Faces Expressive: Chemical Approaches to the Modification of Chemically Inert Peptides

Journal of Peptide Science, Volume 32, Issue 3, March 2026.
As an alternative to the conventional approach, which combines amino acid monomers in a one‐by‐one fashion to peptide derivatives, the chemical modification of existing peptides has attracted significant attention in recent years. However, such approaches generally target the reactive functional groups in cysteine and lysine residues, particularly in ...
Yoshitaka Moriyama, Hikari Sada, Takeshi Nanjo   +2 more
wiley   +1 more source

Enhanced Cooperative Lithium Halide Recognition by Heteroditopic Halogen Bonding (XB) Macrocycles. [PDF]

Inorg Chem
Khianjinda T, Vigromsitdet S, Srisawat P, Sawektreeratana N, Tantirungrotechai J, Sukwattanasinitt M, Harding DJ, Beer PD, Tantirungrotechai Y, Bunchuay T.   +9 more
europepmc   +1 more source

Identifying Drugs Associated With Parkinson's Disease Risk Using Machine Learning

Basic &Clinical Pharmacology &Toxicology, Volume 138, Issue 3, March 2026.
ABSTRACT Machine learning (ML)–based methods have been proposed as a potential approach for identifying candidate drugs to be repurposed as disease‐modifying treatments for Parkinson's disease (PD). We applied an ML‐based signal detection method to identify drugs associated with PD and evaluated the method's generalizability.
Eeva Pylkkö, Émeline Courtois, Anne Paakinaho, Sirpa Hartikainen, Valtteri Kaasinen, Alexis Elbaz, Anne C. M. Thiébaut, Ismaïl Ahmed, Anna‐Maija Tolppanen   +8 more
wiley   +1 more source

Synthesis, Characterization, and Antimicrobial Activity of Some New 2,4-Dihydro-3<i>H</i>-1,2,4-Triazole-3-thione Derivatives. [PDF]

Turk J Pharm Sci
Tok F, Damar Çelik D.
europepmc   +1 more source

High-throughput triazole-based combinatorial click chemistry for the synthesis and identification of functional metal complexes. [PDF]

Nat Commun
Husbands DR, Özsan Ç, Welsh A, Gammons RJ, Frei A.   +4 more
europepmc   +1 more source

Boron Nitride Reinforced Supramolecular Gels Nano‐Assembled with Fungicides toward Soil‐Borne Fungal Disease Management

Advanced Science, Volume 13, Issue 7, 3 February 2026.
This work demonstrates of 2D material‐mediated stimuli‐responsive transport in soft matter systems, pioneers a new class of nano‐bridged carriers with mechanically strengthening and programmable permeability characteristics designed to overcome persistent barriers in soil‐borne disease management.
Li Hao, Jialin Zeng, Weixian Qiu, Jinhui Wang, Xiaoshan Huang, Jiachun Wu, Zhensong Weng, Ziting Yin, Hongjun Zhou, Xinhua Zhou   +9 more
wiley   +1 more source

Thiocarbamoylimidates as Precursors of New 5-Amino-1,2,4-Triazole and Oxadiazole Derivatives In Silico Prediction of Absorption, Distribution, Metabolism, and Excretion Parameters. [PDF]

Chempluschem
Gatri O, Roisnel T, Cordier M, Dorcet V, Efrit ML, Fischmeister C.   +5 more
europepmc   +1 more source

Screen ammonium‐based deep eutectic solvents for CO2 capture: Extended UNIFAC‐DES, calibrated COSMO‐RS, and experiment

AIChE Journal, Volume 72, Issue 2, February 2026.
Abstract CO2 solubility in deep eutectic solvent (DES) is a critical property to indicate the competence of using DESs for carbon capture. This work presents a systematic screening framework with computational and experimental procedures to identify the promising ammonium‐based DESs for CO2 absorption.
Hao Qin, Xiang Zhang, Jiawei Ruan, Kai Sundmacher   +3 more
wiley   +1 more source