Results 41 to 50 of about 73,690 (159)

Regulation of the mitochondrial tricarboxylic acid cycle

Current Opinion in Plant Biology, 2013
Recent years have seen considerable advances in our understanding of the particular physiological roles of the constituent enzymes of the tricarboxylic acid (TCA) cycle. Despite acquiring a fairly comprehensive overview of the functional importance of these proteins relatively little is known concerning how this important pathway is regulated.
Nunes-Nesi, A., Araujo, W., Obata, T., Fernie, A.   +3 more
openaire   +4 more sources

Comprehensive multiomics profiling reveals the protective function of gypenosides against dextran sulfate sodium-induced colitis

Scientific Reports
In this study, we determined whether gypenosides exert a therapeutic effect on colitis. We then explored the underlying mechanism of gypenosides in the treatment of ulcerative colitis (UC) via multiomics analyses. Dextran sulfate sodium (DSS) was used to
Yuan Yang, Xinyuan Li, Fan Huang, Fuchao Cai, Xufeng Ning, Qilin Jiang, Lingshan Zhou, Bin Zeng, Weiwei Zhou, Guangsheng Hu   +9 more
doaj   +1 more source

A novel role for fatty acid transport protein 1 in the regulation of tricarboxylic acid cycle and mitochondrial function in 3T3-L1 adipocytes

Journal of Lipid Research, 2009
Fatty acid transport proteins (FATPs) are integral membrane acyl-CoA synthetases implicated in adipocyte fatty acid influx and esterification. Whereas some FATP1 translocates to the plasma membrane in response to insulin, the majority of FATP1 remains ...
Brian M. Wiczer, David A. Bernlohr
doaj   +1 more source

Detailed profiling of carbon fixation of in silico synthetic autotrophy with reductive tricarboxylic acid cycle and Calvin-Benson-Bassham cycle in Esherichia coli using hydrogen as an energy source

Synthetic and Systems Biotechnology, 2019
Carbon fixation is the main route of inorganic carbon in the form of CO2 into the biosphere. In nature, RuBisCO is the most abundant protein that photosynthetic organisms use to fix CO2 from the atmosphere through the Calvin-Benson-Bassham (CBB) cycle ...
Hsieh-Ting-Yang Cheng, Shou-Chen Lo, Chieh-Chen Huang, Tsung-Yi Ho, Ya-Tang Yang   +4 more
doaj   +1 more source

Rational modification of tricarboxylic acid cycle for improving l-lysine production in Corynebacterium glutamicum

Microbial Cell Factories, 2018
Background Oxaloacetate (OAA) and l-glutamate are essential precursors for the biosynthesis of l-lysine. Reasonable control of all potentially rate-limiting steps, including the precursors supply rate, is of vital importance to maximize the efficiency of
Jian-Zhong Xu, Ze-Hua Wu, Shi-Jun Gao, Weiguo Zhang   +3 more
doaj   +1 more source

O-GlcNAcylation of PGK1 coordinates glycolysis and TCA cycle to promote tumor growth

Nature Communications, 2020
Post-translational modifications of phosphoglycerate kinase 1 (PGK1), a glycoytic enzyme, contribute to cancer progression. Here, the authors show that PGK1 is O-GlcNAcylated at T255, which induces its translocation into mitochondria to suppress the ...
Hao Nie, Haixing Ju, Jiayi Fan, Xiaoliu Shi, Yaxian Cheng, Xiaohui Cang, Zhiguo Zheng, Xiaotao Duan, Wen Yi   +8 more
doaj   +1 more source

The molecular mechanisms of cuproptosis and its relevance to atherosclerosis

Biomolecules & Biomedicine
Atherosclerosis is a chronic inflammatory disease associated with lipid deposition in the vascular intima. Copper is a vital trace element implicated in the onset and progression of atherosclerosis.
Jiankang Wang, Zhian Chen, Hang Shang, Jiajuan Guo   +3 more
doaj   +1 more source

Cadmium induces ferroptosis in mouse spermatocytes by activating the ROS–TCA pathway

Scientific Reports
Cadmium (Cd) can cause testis toxicity, and we have demonstrated Cd induced ferroptosis in testis. However, the underlying toxic mechanism has not yet been fully elucidated. Here, we performed in vitro experiments on a mouse spermatocyte cell line.
Lijuan Xiong, Lijun Yi, Xingying Zeng, Jiyi Huang, Hong Liu, Hong Li   +5 more
doaj   +1 more source

Metabolic Flexibility: Targeting Mitochondrial Dynamics in Cancer Therapy

Acta Medica Martiniana
Various types of cancer exhibit distinct sensitivities to anticancer drugs, reflecting their unique developmental pathways. Exploiting mitochondrial dysfunction in cancer cells presents novel therapeutic opportunities.
Andrea Evinova, Beata Cizmarova, Michal Pokusa, Renata Pecova, Martin Pec, Katarina Dibdiaková   +5 more
doaj   +1 more source

Palmitoylcarnitine and tricarboxylic‐acid‐cycle oxidations [PDF]

FEBS Letters, 1969
Portenhauser, R., Schäfer, G.
openaire   +2 more sources