Results 31 to 40 of about 1,839 (188)
Protein Science, Volume 32, Issue 7, July 2023., 2023 Abstract The interaction between the transcription factor p53 and the ubiquitin ligase MDM2 results in the degradation of p53 and is well‐studied in cancer biology and drug development. Available sequence data suggest that both p53 and MDM2‐family proteins are present across the animal kingdom.
Filip Mihalič +5 more
wiley +1 more source
The Trichoplax genome and the nature of placozoans [PDF]
Nature, 2008 As arguably the simplest free-living animals, placozoans may represent a primitive metazoan form, yet their biology is poorly understood. Here we report the sequencing and analysis of the approximately 98 million base pair nuclear genome of the placozoan Trichoplax adhaerens.
Srivastava, Mansi +20 more
openaire +5 more sources
The Journal of Physiology, Volume 601, Issue 9, Page 1625-1653, 1 May 2023., 2023 Abstract figure legend Polar view of a phylogram of representative members of the DEG/ENaC superfamily, coloured according to phylum (Annelida, yellow; Arthropoda, light green; Chordata, dark green; Cnidaria, blue; Mollusca, dark purple; Nematoda, magenta; Placozoa, red). Construction of the phylogram is described in Fig. 1.
Eva Kaulich +3 more
wiley +1 more source
The diverse functions of the DEG/ENaC family: linking genetic and physiological insights
The Journal of Physiology, Volume 601, Issue 9, Page 1521-1542, 1 May 2023., 2023 Abstract figure legend Schematic illustration of the diverse modulators and stimuli that influence DEG/ENaC function (blue arrows) and the diverse range of functions in which they have been implicated (green arrows), in an array of animals, exemplified by those depicted. Created with Biorender.com.
Eva Kaulich +3 more
wiley +1 more source
Placozoan fiber cells: mediators of innate immunity and participants in wound healing
Scientific Reports, 2021 Placozoa is a phylum of non-bilaterian marine animals. These small, flat organisms adhere to the substrate via their densely ciliated ventral epithelium, which mediates mucociliary locomotion and nutrient uptake.
Tatiana D. Mayorova +7 more
doaj +1 more source
Notizen: Spezifische Verbindungsstrukturen der Faserzellen von Trichoplax adhaerens F. E. Schulze/Special Connecting Structures between Fiber Cells of Trichoplax adhaerens F. E. Schulze [PDF]
Zeitschrift für Naturforschung C, 1974 Abstract In the primitive metazoan, Trichoplax adhaerens, the fiber cells are responsible for the change of shape. Electron microscopy reveals connections between protoplasmic strands of neighbouring cells marked by an osmiophilic disc-like structure. Possible functions are discussed.
F. Schulze +3 more
openalex +2 more sources
Development, Growth &Differentiation, Volume 65, Issue 3, Page 153-160, April 2023., 2023 ndst1 is expressed in anterior neural plate and the trigeminal region in Xenopus neurula. It enhances Wnt signaling in a region‐specific manner by accumulating Wnt ligand. This makes a clear boundary of Wnt signaling, and governs neuroectodermal patterning.
Takayoshi Yamamoto +3 more
wiley +1 more source
Transcription‐independent functions of p53 in DNA repair pathway selection
BioEssays, Volume 45, Issue 1, January 2023., 2023 Transcription‐independent early recruitment and PARylation of p53 at DNA damage sites promotes the recruitment of particular repair factors (e.g. DDB1 and 53BP1) and thereby tipping the balance of repair pathway selection. Abstract Recently discovered transcription‐independent features of p53 involve the choice of DNA damage repair pathway after ...
Yu‐Hsiu Wang, Michael P. Sheetz
wiley +1 more source
Methods in Ecology and Evolution, Volume 13, Issue 9, Page 1885-1898, September 2022., 2022 Abstract Cancer is an understudied but important process in wildlife that is predicted to have a significant effect on the evolution of metazoan species due to negative effects on host fitness. However, gaining understanding of the impact of cancer on species and ecosystems is currently relatively slow as the development of both animal models in which ...
Antoine M. Dujon +7 more
wiley +1 more source
Evolution of factors shaping the endoplasmic reticulum
Traffic, Volume 23, Issue 9, Page 462-473, September 2022., 2022 More than 15 proteins have a role in shaping the endoplasmic reticulum (ER) but studies on the evolution of these factors are lacking. Now, a molecular evolutionary analysis indicates that reticulons, REEPs, atlastin, spastin, lunapark, TMEM33, STIM1 and VAPs likely evolved as early as the last eukaryotic common ancestor (LECA).
Aspasia Kontou +4 more
wiley +1 more source