Results 71 to 80 of about 1,839 (188)

Proteoglycans in mechanobiology of tissues and organs: Normal functions and mechanopathology

Proteoglycan Research, Volume 2, Issue 2, April-June 2024.
Abstract Proteoglycans (PGs) are a diverse class of glycoconjugates that serve critical functions in normal mechanobiology and mechanopathology. Both the protein cores and attached glycosaminoglycan (GAG) chains function in mechanically sensitive processes, and loss of either can contribute to development of pathological conditions. PGs function as key
Mary C. Farach‐Carson, Danielle Wu, Cristiane Miranda França   +2 more
wiley   +1 more source

Phylogenetic position of Placozoa based on large subunit (LSU) and small subunit (SSU) rRNA genes

Genetics and Molecular Biology, 2007
The phylum Placozoa, represented by its single species Trichoplax adhaerens, has always been considered one of the most basal animal clades due to its low morphological complexity.
Fernanda Britto da Silva, Valéria C. Muschner, Sandro L. Bonatto   +2 more
doaj   +1 more source

Importance of fatty acid binding proteins in cellular function and organismal metabolism

Journal of Cellular and Molecular Medicine, Volume 28, Issue 5, March 2024.
Abstract Fatty acid binding proteins (Fabps) are small soluble proteins that are abundant in the cytosol. These proteins are known to bind a myriad of small hydrophobic molecules and have been postulated to serve a variety of roles, yet their precise functions have remained an enigma over half a century of study.
Luis B. Agellon
wiley   +1 more source

Evolution of the TGF-β signaling pathway and its potential role in the ctenophore, Mnemiopsis leidyi. [PDF]

PLoS ONE, 2011
The TGF-β signaling pathway is a metazoan-specific intercellular signaling pathway known to be important in many developmental and cellular processes in a wide variety of animals. We investigated the complexity and possible functions of this pathway in a
Kevin Pang, Joseph F Ryan, Andreas D Baxevanis, Mark Q Martindale   +3 more
doaj   +1 more source

Binary fission in Trichoplax is orthogonal to the subsequent division plane

Mechanisms of Development, 2020
Asexual reproduction in Trichoplax occurs mainly by binary fission and occasionally by the budding of epithelial spheres called "swarmers". The process that leads to binary fission and the mechanisms involved in this segregation are practically unknown.
Jorge, Zuccolotto-Arellano, Rodrigo, Cuervo-González   +1 more
openaire   +2 more sources

Features of a novel protein, rusticalin, from the ascidian Styela rustica reveal ancestral horizontal gene transfer event

Mobile DNA, 2019
Background The transfer of genetic material from non-parent organisms is called horizontal gene transfer (HGT). One of the most conclusive cases of HGT in metazoans was previously described for the cellulose synthase gene in ascidians.
Maria A. Daugavet, Sergey Shabelnikov, Alexander Shumeev, Tatiana Shaposhnikova, Leonid S. Adonin, Olga Podgornaya   +5 more
doaj   +1 more source

Identification of 526 conserved metazoan genetic innovations exposes a new role for cofactor E-like in neuronal microtubule homeostasis. [PDF]

PLoS Genetics, 2013
The evolution of metazoans from their choanoflagellate-like unicellular ancestor coincided with the acquisition of novel biological functions to support a multicellular lifestyle, and eventually, the unique cellular and physiological demands of ...
Melissa Y Frédéric, Victor F Lundin, Matthew D Whiteside, Juan G Cueva, Domena K Tu, S Y Catherine Kang, Hansmeet Singh, David L Baillie, Harald Hutter, Miriam B Goodman, Fiona S L Brinkman, Michel R Leroux   +11 more
doaj   +1 more source

Functional characterization of p53 pathway components in the ancient metazoan Trichoplax adhaerens [PDF]

Scientific Reports, 2016
AbstractThe identification of genes encoding a p53 family member and an Mdm2 ortholog in the ancient placozoan Trichoplax adhaerens advocates for the evolutionary conservation of a pivotal stress-response pathway observed in all higher eukaryotes. Here, we recapitulate several key functionalities ascribed to this known interacting protein pair by ...
Siau, J.W, Coffill, C.R, Zhang, W.V, Tan, Y.S, Hundt, J, Lane, D, Verma, C, Ghadessy, F   +7 more
openaire   +3 more sources

From tumors to species: a SCANDAL hypothesis

Biology Direct, 2019
Some tumor cells can evolve into transmissible parasites. Notable examples include the Tasmanian devil facial tumor disease, the canine transmissible venereal tumor and transmissible cancers of mollusks.
A. Y. Panchin, V. V. Aleoshin, Y. V. Panchin   +2 more
doaj   +1 more source

Evolution of selenoproteins in the metazoan

BMC Genomics, 2012
Background The selenocysteine (Sec) containing proteins, selenoproteins, are an important group of proteins present throughout all 3 kingdoms of life.
Jiang Liang, Ni Jiazuan, Liu Qiong
doaj   +1 more source