Results 41 to 50 of about 1,406 (173)

Why Homoscleromorph Sponges Have Ciliated Epithelia: Evidence for an Ancestral Role in Mucociliary Driven Particle Flux. [PDF]

J Exp Zool B Mol Dev Evol
Epithelia are typically ciliated, except in sponges. Of all Porifera only Homoscleromorphs have motile cilia on their epithelia. Our data highlight the presence of cilia and mucociliary particle transport as a common feature of metazoa and a secondary loss in other sponge lineages.
Price VL, Nanayakkara A, Pasini A, Bazellières E, Vernale A, Rocher C, Borchiellini C, Le Bivic A, Renard E, Leys SP.   +9 more
europepmc   +2 more sources

The early ANTP gene repertoire: insights from the placozoan genome. [PDF]

PLoS ONE, 2008
The evolution of ANTP genes in the Metazoa has been the subject of conflicting hypotheses derived from full or partial gene sequences and genomic organization in higher animals.
Bernd Schierwater, Kai Kamm, Mansi Srivastava, Daniel Rokhsar, Rafael D Rosengarten, Stephen L Dellaporta   +5 more
doaj   +1 more source

Function and phylogeny support the independent evolution of an ASIC-like Deg/ENaC channel in the Placozoa

Communications Biology, 2023
ASIC channels are bilaterian proton-gated sodium channels belonging to the large and functionally-diverse Deg/ENaC family that also includes peptide- and mechanically-gated channels.
Wassim Elkhatib, Luis A. Yanez-Guerra, Tatiana D. Mayorova, Mark A. Currie, Anhadvir Singh, Maria Perera, Julia Gauberg, Adriano Senatore   +7 more
doaj   +1 more source

Amino acids integrate behaviors in nerveless placozoans

Frontiers in Neuroscience, 2023
Placozoans are the simplest known free-living animals without recognized neurons and muscles but a complex behavioral repertoire. However, mechanisms and cellular bases of behavioral coordination are unknown.
Mikhail A. Nikitin, Daria Y. Romanova, Simkha I. Borman, Leonid L. Moroz, Leonid L. Moroz   +4 more
doaj   +1 more source

Comparative genomics and the nature of placozoan species. [PDF]

PLoS Biology, 2018
Placozoans are a phylum of nonbilaterian marine animals currently represented by a single described species, Trichoplax adhaerens, Schulze 1883. Placozoans arguably show the simplest animal morphology, which is identical among isolates collected ...
Michael Eitel, Warren R Francis, Frédérique Varoqueaux, Jean Daraspe, Hans-Jürgen Osigus, Stefan Krebs, Sergio Vargas, Helmut Blum, Gray A Williams, Bernd Schierwater, Gert Wörheide   +10 more
doaj   +1 more source

Structural basis for binding of the renal carcinoma target hypoxia‐inducible factor 2α to prolyl hydroxylase domain 2

Proteins: Structure, Function, and Bioinformatics, Volume 91, Issue 11, Page 1510-1524, November 2023., 2023
Abstract The hypoxia‐inducible factor (HIF) prolyl‐hydroxylases (human PHD1‐3) catalyze prolyl hydroxylation in oxygen‐dependent degradation (ODD) domains of HIFα isoforms, modifications that signal for HIFα proteasomal degradation in an oxygen‐dependent manner. PHD inhibitors are used for treatment of anemia in kidney disease. Increased erythropoietin
William D. Figg Jr., Giorgia Fiorini, Rasheduzzaman Chowdhury, Yu Nakashima, Anthony Tumber, Michael A. McDonough, Christopher J. Schofield   +6 more
wiley   +1 more source

Defining bone fide effectors of RAS GTPases

BioEssays, Volume 45, Issue 9, September 2023., 2023
RAS GTPases transmit extracellular signals to multiple intracellular signalling pathways through direct interaction with effector proteins. These proteins typically employ RAS‐binding RBD domains to complex with activated GTPases, but the specificity of these interactions remains poorly explored and there remain few data describing the mechanistic ...
Matthew J. Smith
wiley   +1 more source

Evolution of affinity between p53 transactivation domain and MDM2 across the animal kingdom demonstrates high plasticity of motif‐mediated interactions

Protein Science, Volume 32, Issue 7, July 2023., 2023
Abstract The interaction between the transcription factor p53 and the ubiquitin ligase MDM2 results in the degradation of p53 and is well‐studied in cancer biology and drug development. Available sequence data suggest that both p53 and MDM2‐family proteins are present across the animal kingdom.
Filip Mihalič, Emma Åberg, Pouria Farkhondehkish, Niels Theys, Eva Andersson, Per Jemth   +5 more
wiley   +1 more source

Physiological insight into the conserved properties of Caenorhabditis elegans acid‐sensing degenerin/epithelial sodium channels

The Journal of Physiology, Volume 601, Issue 9, Page 1625-1653, 1 May 2023., 2023
Abstract figure legend Polar view of a phylogram of representative members of the DEG/ENaC superfamily, coloured according to phylum (Annelida, yellow; Arthropoda, light green; Chordata, dark green; Cnidaria, blue; Mollusca, dark purple; Nematoda, magenta; Placozoa, red). Construction of the phylogram is described in Fig. 1.
Eva Kaulich, Patrick T. N. McCubbin, William R. Schafer, Denise S. Walker   +3 more
wiley   +1 more source

A review of the methods used to induce cancer in invertebrates to study its effects on the evolution of species and ecosystem functioning

Methods in Ecology and Evolution, Volume 13, Issue 9, Page 1885-1898, September 2022., 2022
Abstract Cancer is an understudied but important process in wildlife that is predicted to have a significant effect on the evolution of metazoan species due to negative effects on host fitness. However, gaining understanding of the impact of cancer on species and ecosystems is currently relatively slow as the development of both animal models in which ...
Antoine M. Dujon, Justine Boutry, Sophie Tissot, Jordan Meliani, Lena Guimard, Océane Rieu, Beata Ujvari, Frédéric Thomas   +7 more
wiley   +1 more source