Trichuris muris Model: Role in Understanding Intestinal Immune Response, Inflammation and Host Defense [PDF]
Pathogens, 2021 Several parasites have evolved to survive in the human intestinal tract and over 1 billion people around the world, specifically in developing countries, are infected with enteric helminths.
Yeganeh Yousefi +4 more
doaj +3 more sources
Functional Characterization of the Oxantel-Sensitive Acetylcholine Receptor from Trichuris muris [PDF]
Pharmaceuticals, 2021 The human whipworm, Trichuris trichiura, is estimated to infect 289.6 million people globally. Control of human trichuriasis is a particular challenge, as most anthelmintics have a limited single-dose efficacy, with the striking exception of the narrow ...
Tina V. A. Hansen +4 more
doaj +3 more sources
Glucose Absorption by the Bacillary Band of Trichuris muris. [PDF]
PLoS Neglected Tropical Diseases, 2016 BACKGROUND:A common characteristic of Trichuris spp. infections in humans and animals is the variable but low efficacy of single-dose benzimidazoles currently used in mass drug administration programmes against human trichuriasis.
Tina V A Hansen +5 more
doaj +5 more sources
Characterization of Trichuris muris secreted proteins and extracellular vesicles provides new insights into host–parasite communication [PDF]
Journal of Extracellular Vesicles, 2018 Whipworms are parasitic nematodes that live in the gut of more than 500 million people worldwide. Owing to the difficulty in obtaining parasite material, the mouse whipworm Trichuris muris has been extensively used as a model to study human whipworm ...
Md Hasanuzzaman Talukder +2 more
exaly +3 more sources
Trichuris muris infection drives cell-intrinsic IL4R alpha independent colonic RELMα+ macrophages. [PDF]
PLoS Pathogens, 2021 The intestinal nematode parasite Trichuris muris dwells in the caecum and proximal colon driving an acute resolving intestinal inflammation dominated by the presence of macrophages.
Ruth Forman +9 more
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Trichuris muris egg-hatching assay for anthelminthic drug discovery and characterization [PDF]
International Journal for Parasitology: Drugs and Drug Resistance, 2023 Trichuriasis is a neglected tropical disease widely distributed among tropical and sub-tropical areas and associated with poverty and lack of access to safe drinking water, sanitation and hygiene.
Anastasia Schärer +2 more
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Whip-LAMP: a novel LAMP assay for the detection of Trichuris muris-derived DNA in stool and urine samples in a murine experimental infection model [PDF]
Parasites & Vectors, 2020 Background Trichuris trichiura (human whipworm) infects an estimated 477 million individuals worldwide. In addition to T. trichiura, other Trichuris species can cause an uncommon zoonosis and a number of human cases have been reported.
Pedro Fernández-Soto +9 more
doaj +2 more sources
The Influence of Innate Immunity, Adaptive Immunity and Diet on Intestinal Microbiota Following Trichuris muris Infection. [PDF]
Parasite ImmunolABSTRACT Trichuris trichiura infects nearly 500 million people worldwide, causing intestinal inflammation, malnutrition, and growth impairment, particularly in children from low‐resource settings. While host immunity is central to parasite clearance, diet and the gut microbiota may also modulate infection.
Walusimbi B +6 more
europepmc +3 more sources
Benzimidazole and aminoalcohol derivatives show in vitro anthelmintic activity against Trichuris muris and Heligmosomoides polygyrus [PDF]
Parasites & Vectors, 2022 Background Infections by gastrointestinal nematodes cause significant economic losses and disease in both humans and animals worldwide. The discovery of novel anthelmintic drugs is crucial for maintaining control of these parasitic infections.
Elora Valderas-García +9 more
doaj +2 more sources
Trickle infection and immunity to Trichuris muris. [PDF]
PLoS Pathogens, 2019 The majority of experiments investigating the immune response to gastrointestinal helminth infection use a single bolus infection. However, in situ individuals are repeatedly infected with low doses.
Maya Glover +3 more
doaj +2 more sources