Dietary fibre promotes chronic gut parasite infection via direct and time-dependent modulation of innate immunity [PDF]
MicrobiomeBackground Dietary fibre is an important regulator of the gut microbiome and is associated with many health benefits. However, high levels of fibre intake have also been reported to exacerbate some diseases.
Laura J. Myhill +13 more
doaj +2 more sources
A genome-scale metabolic model of parasitic whipworm
Nature Communications, 2023 Genome-scale metabolic models are widely used to enhance our understanding of metabolic features of organisms, host-pathogen interactions and to identify therapeutics for diseases.
Ömer F. Bay +4 more
doaj +1 more source
Morphological and molecular characterization of Trichuris muris (Nematoda: Trichuridae): studies from two commensal rodent species [PDF]
, 2023 In this paper we re-describe Trichuris muris based on morphological data following isolation from two commensal rodent species, Mus musculus from Mexico and Rattus rattus from Argentina.
Panti May, Jesús Alonso +6 more
core +1 more source
An antagonist of the retinoid X receptor reduces the viability of Trichuris muris in vitro. [PDF]
BMC Infect Dis, 2014 Background Trichuriasis is a parasitic disease caused by the human whipworm, Trichuris trichiura. It affects millions worldwide, particularly in the tropics.
Hurst RJ +6 more
europepmc +2 more sources
Whipworm secretions and their roles in host-parasite interactions
Parasites & Vectors, 2022 Whipworm (Trichuris) is a genus of roundworms that causes gastrointestinal infections in humans and animals. Of particular interest are T. trichiura, the causative agent of human trichuriasis, a neglected tropical disease that affects 477 million people ...
Rebecca K. Shears, Richard K. Grencis
doaj +1 more source
In vitro and in vivo efficacy of Monepantel (AAD 1566) against laboratory models of human intestinal nematode infections. [PDF]
PLoS Neglected Tropical Diseases, 2011 BACKGROUND: Few effective drugs are available for soil-transmitted helminthiases and drug resistance is of concern. In the present work, we tested the efficacy of the veterinary drug monepantel, a potential drug development candidate compared to standard
Lucienne Tritten +2 more
doaj +1 more source
Acta et Commentationes: Ştiinţe Exacte şi ale Naturii, 2022 The taxonomic structure consists of 3 classes, 10 families, 12 genera and 13 species, of which 6 parasitic species belong to the Cestoda class (Skrjabinotaenia lobata, Catenotaenia cricetorum, Hydatigera taeniaeformis, Hydatigera taeniaeformis, Taenia ...
Oleg Chihai +7 more
doaj +1 more source
Rodent Models for the Study of Soil-Transmitted Helminths: A Proteomics Approach
Frontiers in Cellular and Infection Microbiology, 2021 Soil-transmitted helminths (STH) affect hundreds of millions worldwide and are some of the most important neglected tropical diseases in terms of morbidity.
Karen J. Montaño +2 more
doaj +1 more source
International Journal for Parasitology: Drugs and Drug Resistance, 2018 Over 4.5 billion people are at risk of infection with soil transmitted helminths and there are concerns about the development of resistance to the handful of frontline nematocides in endemic populations.
Madhu Sundaraneedi +11 more
doaj +1 more source
Development of an in vitro drug sensitivity assay for Trichuris muris first-stage larvae [PDF]
, 2013 Trichuriasis represents a major public health problem in the developing world and is regarded as a neglected disease. Albendazole and mebendazole, the two drugs of choice against trichuriasis display only moderate cure rates, hence alternative drugs are ...
Jennifer Keiser +5 more
core +1 more source