Results 11 to 20 of about 18,425 (138)

Bacteria-induced egg hatching differs for Trichuris muris and Trichuris suis [PDF]

Parasites & Vectors, 2015
Background Eggs of the porcine whipworm Trichuris suis are currently explored in human clinical trials as a treatment of immune-mediated diseases. In this context, only the infective, embryonated eggs, constitute the Active Pharmaceutical Ingredient (API)
Nermina Vejzagić, Roberto Adelfio, Jennifer Keiser, Helene Kringel, Stig Milan Thamsborg, Christian M.O. Kapel   +5 more
doaj   +3 more sources

Activity of oxantel pamoate monotherapy and combination chemotherapy against Trichuris muris and hookworms: revival of an old drug. [PDF]

PLoS Neglected Tropical Diseases, 2013
BACKGROUND: It is widely recognized that only a handful of drugs are available against soil-transmitted helminthiasis, all of which are characterized by a low efficacy against Trichuris trichiura, when administered as single doses.
Jennifer Keiser, Lucienne Tritten, Angelika Silbereisen, Benjamin Speich, Roberto Adelfio, Mireille Vargas   +5 more
doaj   +3 more sources

Identification, Characterization, and Structure of Tm16 from Trichuris muris [PDF]

Journal of Parasitology Research, 2017
Trichuriasis is a disease of poverty for which excretory and secretory (ES) products that induce the protective immunity are being investigated as candidate vaccines antigens. In this study, ES products of T. muris and immune sera were produced.
Zhuyun Liu, Alan Kelleher, Shanii Tabb, Junfei Wei, Jeroen Pollet, Peter J. Hotez, Maria Elena Bottazzi, Bin Zhan, Oluwatoyin A. Asojo   +8 more
doaj   +2 more sources

Immune-driven alterations in mucin sulphation is an important mediator of Trichuris muris helminth expulsion. [PDF]

PLoS Pathogens, 2017
Mucins are heavily glycosylated proteins that give mucus its gel-like properties. Moreover, the glycans decorating the mucin protein core can alter the protective properties of the mucus barrier. To investigate whether these alterations could be parasite-
Sumaira Z Hasnain, Paul A Dawson, Rohan Lourie, Peter Hutson, Hui Tong, Richard K Grencis, Michael A McGuckin, David J Thornton   +7 more
doaj   +2 more sources

Caecal Epithelium-Derived Thymic Stromal Lymphopoietin is not Required for Protective Immunity Against Whipworm. [PDF]

Eur J Immunol
Immunity to Trichuris muris infection is unimpacted by epithelial knockout of TSLP expression. Imaging of transcription in the caecum reveals Tslp transcription throughout infection in EpCAM‐, Foxl1‐, Ccl24‐ lamina propria‐resident cells, contributing during the expulsion phase of infection. ABSTRACT Recent research examining classical type two alarmin
Lynch CP, Thompson S, Pallott EC, Campbell L, Lee SH, Grencis RK.   +5 more
europepmc   +2 more sources

Selective Packaging of miR-22 and miR-29 Orthologues into Extracellular Vesicles of the Porcine Whipworm Trichuris Suis. [PDF]

J Extracell Vesicles
ABSTRACT Helminths modulate host immunity, and in this respect, the porcine whipworm Trichuris suis has been explored clinically as an immunotherapy for inflammatory diseases. T. suis secretes a complex mixture of excretory/secretory products (ESP), including extracellular vesicles (EVs), nanosized membranous particles with bioactive cargoes of lipids,
Whitehead B, Mardahl M, Hansen EP, Fromm B, Borup A, Boysen AT, Atay JCL, Nørregaard R, Stensballe A, Andersen SD, Gasser RB, Brucale M, Valle F, Ridolfi A, Glud EN, Fredholm M, Williams AR, Thamsborg SM, Palmfedt J, Nejsum P.   +19 more
europepmc   +2 more sources

Synthesis and Antiparasitic Activities of New Organometallic Derivatives of the Benzimidazole Anthelmintic Drugs. [PDF]

Chembiochem
Organometallic derivatization of existing drugs is a common strategy to look for new drug candidates. This work describes the derivatization of the benzimidazole anthelmintic scaffold, from the synthesis of the organometallic derivatives to the evaluation of their biological properties. It highlights a broad range of antiparasitic activities and leaves
Ludwig C, Taki AC, Byrne JJ, Mesdom P, Blacque O, Häberli C, Zumkehr T, Scalese G, Pérez-Díaz L, Gambino D, Lundström-Stadelmann B, Keiser J, Gasser RB, Cariou K, Gasser G.   +14 more
europepmc   +2 more sources

Chronic Trichuris muris infection causes neoplastic change in the intestine and exacerbates tumour formation in APC min/+ mice. [PDF]

PLoS Neglected Tropical Diseases, 2017
Incidences of infection-related cancers are on the rise in developing countries where the prevalence of intestinal nematode worm infections are also high. Trichuris muris (T.
Kelly S Hayes, Laura J Cliffe, Alison J Bancroft, Simon P Forman, Seona Thompson, Cath Booth, Richard K Grencis   +6 more
doaj   +2 more sources

Structural Requirements for Dihydrobenzoxazepinone Anthelmintics: Actions against Medically Important and Model Parasites: <i>Trichuris muris</i>, <i>Brugia malayi</i>, <i>Heligmosomoides polygyrus</i>, and <i>Schistosoma mansoni</i>. [PDF]

ACS Infect Dis, 2021
Nine hundred million people are infected with the soil-transmitted helminths Ascaris lumbricoides (roundworm), hookworm, and Trichuris trichiura (whipworm).
Partridge FA, Bataille CJR, Forman R, Marriott AE, Forde-Thomas J, Häberli C, Dinsdale RL, O'Sullivan JDB, Willis NJ, Wynne GM, Whiteland H, Archer J, Steven A, Keiser J, Turner JD, Hoffmann KF, Taylor MJ, Else KJ, Russell AJ, Sattelle DB.   +19 more
europepmc   +2 more sources

Investigating the importance of B cells and antibodies during Trichuris muris infection using the IgMi mouse [PDF]

Journal of Molecular Medicine, 2020
Rinal Sahputra, Kathryn Else, Werner Müller   +2 more
exaly   +2 more sources