A dose-effect network meta-analysis model: an application in antidepressants [PDF]
Network meta-analysis (NMA) has been used to answer a range of clinical questions about the preferable intervention for a given condition. Although the effectiveness and safety of pharmacological agents depend on the dose administered, NMA applications typically ignore the role that drugs dosage play on the results.
arxiv +1 more source
Tricyclic antidepressant poisoning [PDF]
Tricyclic antidepressant poisoning causes predictable electrocardiographic abnormalities and can be lethal. Cardiac arrhythmias, hypotension, seizures, and coma are common. Sodium bicarbonate is still considered the treatment of choice for severe toxicity, although a variety of supportive measures may be taken.
openaire +2 more sources
The impact of clustering binary data on relative risk towards a study of inferential methods [PDF]
In epidemiological cohort studies, the relative risk (also known as risk ratio) is a major measure of association to summarize the results of two treatments or exposures. Generally, it measures the relative change in disease risk as a result of treatment application.
arxiv
Prolonged coma due to amitriptyline overdose and genetic polymorphism: a case report
Background Reduced consciousness has a wide variety of possible causes, not infrequently being toxic in nature. An intoxication might be obvious, but in this paper an unexpected case with a tricyclic antidepressant is presented.
Tijs van de Wint+4 more
doaj +1 more source
Antidepressant Use and Risk of Venous Thromboembolism: A Systematic Review and Meta-Analysis
Purpose. Studies provided conflicting results on whether antidepressant use increased the risk of venous thromboembolism (VTE). Our aim was to examine the association between antidepressant use and the risk of VTE. Methods.
Ying Wang+3 more
doaj +1 more source
Exploratory Data Analysis of Electric Tricycle as Sustainable Public Transport Mode in General Santos City Using Logistic Regression [PDF]
General Santos City, as the tuna capital of the Philippines, relies with the presence of tricycles in moving people and goods. Considered as a highly-urbanized city, General Santos City serves as vital link of the entire SOCKSARGEN region's economic activities.
arxiv
Background Cognitive impairment is very common in late-life depression, principally affecting executive skills and information processing speed. The aim of the study was to examine the effect of antidepressant treatment on cognitive performances over a ...
Isabelle Carrière+9 more
doaj +1 more source
Maximum values of the edge Mostar index in tricyclic graphs [PDF]
For a graph $G$, the edge Mostar index of $G$ is the sum of $|m_u(e|G)-m_v(e|G)|$ over all edges $e=uv$ of $G$, where $m_u(e|G)$ denotes the number of edges of $G$ that have a smaller distance in $G$ to $u$ than to $v$, and analogously for $m_v(e|G)$.
arxiv
ST-T segment changes in patients with tricyclic antidepressant poisoning
Objective: Tricyclic antidepressant (TCA) poisoning is among highly prevalent and potentially dangerous toxicities. ST-T changes are observed in the electrocardiogram (ECG) of most of TCA poisoned patients.
Farzad Gheshlaghi+5 more
doaj +1 more source
Addressing the Side Effects of Contemporary Antidepressant Drugs: A Comprehensive Review
Randomized trials have shown that selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) have better safety profiles than classical tricyclic antidepressants (TCAs).
Sheng-Min Wang+6 more
semanticscholar +1 more source