Results 91 to 100 of about 2,712 (224)

Research progress in stem cell therapy for Wilson disease

Regenerative Therapy
Wilson disease (WD), also known as hepatolenticular degeneration, is an autosomal recessive disorder characterized by disorganized copper metabolism caused by mutations in the ATP7B gene.
Xianlang Xiong, Ce Gao, Xiangying Meng, Aihui Liu, Xin Gong, Yi Sun   +5 more
doaj   +1 more source

Effect of hydroalcoholic extract of Chevil (Ferulago angulata) on glucose and lipid in diabetic male rats [PDF]

, 2015
Introduction: Diabetes is a metabolic disease characterised by chronic hyperglycemia. Considering the properties antioxidant of the Chevil plant compounds, this study performed to determine the effect of hydroalcoholic extract of Chevil on serum glucose ...
Alipanah-Moghadam, Reza., Ebrahimi, Marzieh., Ghezel-Sofli, Eslam., Heidarian, Esfandiar., Mazani, Mohammad., Musavi-Ezmareh, Seyedeh Fatemeh., Rafieian-Kopaei, Mahmoud., Shahinfard, Najmeh.   +7 more
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Preventive and therapeutic effects of tomato juice on the growth of fibrosarcoma tumor cells in Balb/c mice. [PDF]

, 2009
چکیده: زمینه و هدف: فیبروسارکوم توموری است با منشا سلول های مزانشیمال که از سلول های فیبروبلاست بدخیم و در یک زمینه کلاژن تشکیل شده است. اثرات ضد سرطان لیکوپن موجود در گوجه فرنگی در برخی از سرطان ها ثابت شده است. لذا این مطالعه با هدف تعیین اثرات پیشگیری
Farokhi, Effat., Parvin, Neda., Shahabi, Ghorban Ali., shirzad, Hedayatollah., Yosefi, Hossein.   +4 more
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Effect of quercetin on methotrexate-induced hepatic and renal damages in male rats [PDF]

, 2015
Background and purpose: Methotrexate as a chemotherapy drug causes chronic liver damage, infiltration of neutrophils, oxidative stress, and direct renal tubular damage. Quercetin is a flavonoid with antioxidant and anti-inflammatory properties. Therefore,
Gholami-Arjenaki, Mostafa., Heidarian, Esfandiar., Karimi-Taghanaki, Alireza., Mardani, Gashtasb., Moradi, Elham., Normohammadian, Zahra., Saffari-Chaleshtori, Javad.   +6 more
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Wilson’s disease: Clinical practice guidelines of the Indian National Association for the study of Liver (INASL), The Indian Society of Pediatric Gastroenterology, Hepatology and Nutrition (ISPGHAN) and the Movement Disorders Society of India (MDSI) [PDF]

, 2018
Clinical practice guidelines for Wilson's disease have been published by AASLD and EASL in 2008 and 2012 respectively. Their focus was on the hepatic aspects of the disease.
Alam, Seema, Bavdekar, Ashish, Devarbhavi, Harshad, Dhawan, Anil, Dhiman, Radha K., Eapen, C.E., Goyal, Vinay, Kandadai, Rukmini Mridula, Matthai, John, Mohan, Neelam, Nagral, Aabha, Poddar, Ujjal, Prashanth, L.K., Sankaranarayanan, Srinivas, Sarma, Moinak Sen, Sathiyasekaran, Malathi, Sibal, Anupam, Sinha, Sanjib, Srivastava, Anshu, Thapa, Baburam R., Wadia, Pettarusp, Yachha, Surendra K.   +21 more
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Copper-Induced Neurodegenerative Disorders and Therapeutic Potential of Curcumin-Loaded Nanoemulsion

Toxics
Copper accumulation in neurons induces oxidative stress, disrupts mitochondrial activity, and accelerates neuronal death, which is central to the pathophysiology of neurodegenerative diseases like Wilson disease.
Govind Hake, Akshada Mhaske, Rahul Shukla, Swaran Jeet Singh Flora   +3 more
doaj   +1 more source

Effects of quercetin on signaling proteins (PSTAT3, pERK1/2, pAKT) and interleukin-6 gene expression in prostate cancer pc3 cells [PDF]

, 2017
Background and purpose: Interleukin-6 (IL-6) causes the progression of prostate cancer through pSTAT3, pERK1/2, and pAKT cell signaling proteins. Quercetin, an herbal antioxidant, has antitumor effect. The aim of this study was to evaluate the effects of
Abbasi-Veldani, Akram., Amini, Sayed Asadollah., Ghatreh-Samani, Keihan., Heidarian, Esfandiar.   +3 more
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Protective effects of hydroalcoholic extract of Ferulago angulata against gentamicin-induced nephrotoxicity in rats [PDF]

, 2016
Gentamicin can lead to acute tubular injury and kidney dysfunction. This study aimed to evaluate the effect of Ferulago angulata on kidney function and other markers in rats with gentamicin-induced nephrotoxicity. Materials and Methods.
Gholami-Arjenaki, Mostafa., Heidarian, Esfandiar., Khoshdel, Abolfazl., Valipour, Parisa.   +3 more
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Wilson's disease: an analysis of 28 Brazilian children

Clinics, 2012
OBJECTIVES: Clinical-laboratory and evolutionary analysis of twenty-eight patients with Wilson's disease. METHODS: Twenty-eight children (twelve females and sixteen males) with Wilson's disease were evaluated retrospectively between 1987 and 2009, with a
Rodolpho Truffa Kleine, Renata Mendes, Renata Pugliese, Irene Miura, Vera Danesi, Gilda Porta   +5 more
doaj   +1 more source

Does Misery Love Company? Evidence from pharmaceutical markets before and after the Orphan Drug Act [PDF]

With substantial fixed costs of drug development, more common conditions can support more products. If additional pharmaceutical products are beneficial, they will attract greater consumption and promote better health, e.g. greater longevity.
Frank R. Lichtenberg, Joel Waldfogel
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