Results 91 to 100 of about 1,630 (179)

Copper Poisoning with Emphasis on Its Clinical Manifestations and Treatment of Intoxication

Advances in Public Health
Background. Copper is an essential trace element found in the human body in an oxidized (Cu II) and reduced (Cu I) form. It plays a crucial role in the integrity and function of proteins and enzymes. Short-term and long-term exposure to copper can result
Mehrdad Rafati Rahimzadeh, Mehravar Rafati Rahimzadeh, Sohrab Kazemi, Ali Akbar Moghadamnia   +3 more
doaj   +1 more source

Wilson’s Disease in Oman: A National Cohort Study of Clinical Spectrum, Diagnostic Delay, and Long-Term Outcomes

Clinics and Practice
Background/Objectives: Wilson’s disease (WD) is a rare autosomal recessive disorder of copper metabolism that results in hepatic, neurological, and psychiatric manifestations.
Said A. Al-Busafi, Juland N. Al Julandani, Zakariya Alismaeili, Juhaina J. Al Raisi   +3 more
doaj   +1 more source

Image_1_A Dose Escalation Study of Trientine Plus Carboplatin and Pegylated Liposomal Doxorubicin in Women With a First Relapse of Epithelial Ovarian, Tubal, and Peritoneal Cancer Within 12 Months After Platinum-Based Chemotherapy.TIF

, 2019
Background: Epithelial ovarian cancer (EOC) is the leading cause of gynecological cancer-related deaths worldwide. Preclinical studies found that copper-lowering agents could re-sensitize platinum-resistant cancer cells by enhancing the human copper ...
Macus Tien Kuo (6733241), Cheng-Yang Chou (484656), Ya-Min Cheng (751952), Yi-Sheng Liu (844242), Pei-Ying Wu (527605), Yu-Fang Huang (820038)   +5 more
core   +1 more source

Table_1_A Dose Escalation Study of Trientine Plus Carboplatin and Pegylated Liposomal Doxorubicin in Women With a First Relapse of Epithelial Ovarian, Tubal, and Peritoneal Cancer Within 12 Months After Platinum-Based Chemotherapy.DOCX

, 2019
Background: Epithelial ovarian cancer (EOC) is the leading cause of gynecological cancer-related deaths worldwide. Preclinical studies found that copper-lowering agents could re-sensitize platinum-resistant cancer cells by enhancing the human copper ...
Macus Tien Kuo (6733241), Cheng-Yang Chou (484656), Ya-Min Cheng (751952), Yi-Sheng Liu (844242), Pei-Ying Wu (527605), Yu-Fang Huang (820038)   +5 more
core   +1 more source

Dr John Walshe and the treatment of Wilson's disease

, 2012
Treatment of Wilson’s disease was transformed in the 20th century by the introduction of four drugs, which could be administered orally: D-penicillamine, triethylenetetramine (trientine) dihydrochloride, zinc acetate and ammonium tetrathiomolybdate ...
Rupert Purchase (16039694)
core   +1 more source

Comment on “Trientine Tetrahydrochloride, From Bench to Bedside: A Narrative Review”

The following comments concern statements made in a recently published profile (co-authored by employees of Orphalan, Inc, Boston, USA) of the tetrahydrochloride of triethylenetetramine (INN: trientine) used for the treatment of Wilson disease.
Rupert Purchase (20413295)
core  

Trientine ameliorates bleomycin-induced pulmonary fibrosis in rats through copper chelation and modulation of the CTR1/LOX/COL pathway. [PDF]

Inflammopharmacology
Khalil IT, Elshal M, Elsayed NM, Radwan A.   +3 more
europepmc   +1 more source

The Trientine Crisis in Canada: A Call to Advocacy

Canadian Journal of Gastroenterology and Hepatology, 2014
Natasha Chandok, Eve A Roberts
doaj   +1 more source

A Novel Homozygous <i>ATP7B</i> Splice-Site Variant Causes Late-Onset Hepatic Wilson Disease. [PDF]

ACG Case Rep J
Alkhateb O, Rockey DC, Barada K.
europepmc   +1 more source

Dr H. B. F. (Hal) Dixon (1928-2008)

, 2010
A University of Cambridge collaboration between Dr Hal Dixon and Dr John Walshe in the introduction of trientine dihydrochloride for the treatment of Wilson’s disease is ...
Rupert Purchase (16039694)
core