Results 81 to 90 of about 1,630 (179)

Copper-Induced Neurodegenerative Disorders and Therapeutic Potential of Curcumin-Loaded Nanoemulsion

Toxics
Copper accumulation in neurons induces oxidative stress, disrupts mitochondrial activity, and accelerates neuronal death, which is central to the pathophysiology of neurodegenerative diseases like Wilson disease.
Govind Hake, Akshada Mhaske, Rahul Shukla, Swaran Jeet Singh Flora   +3 more
doaj   +1 more source

Alterations of lipid metabolism in Wilson disease

Lipids in Health and Disease, 2011
Introduction Wilson disease (WD) is an inherited disorder of human copper metabolism, characterised by accumulation of copper predominantly in the liver and brain, leading to severe hepatic and neurological disease.
Stremmel Wolfgang, Eckert Nicola, Pfeiffenberger Jan, Gotthardt Daniel, Gohdes Annina, Seessle Jessica, Reuner Ulrike, Weiss Karl   +7 more
doaj   +1 more source

A Phase 2 Trial of Trientine for Hypertrophic Cardiomyopathy

Background and Aims: Pathophysiological features of hypertrophic cardiomyopathy include left ventricular hypertrophy, myocardial fibrosis and myocardial energy deficiency. Depletion of cardiomyocyte copper I ions leads to impaired mitochondrial function;

core   +3 more sources

The effect of Trientine and flaxseed oil on serum Copper and lipoproteins in diabetic rats

, 2013
Background: Diabetes causes disorders in serum trace elements and lipoprotein metabolism. The aim of this study was to determine the effect of co-administration of trientine (Cu chelator agent) and flaxseed oil on serum copper and lipoproteins in ...
Heidarian, E., Pournajaf, E., Rezaei, A.
core  

Combined effects of treatment with trientine, a copper-chelating agent, and X-irradiaion on tumor growth in transplantation model of a murine fibrosarcoma [PDF]

ArticleCombined effects of treatment with trientine, a copper-chelating agent, and X-irradiation on development of fibrosarcoma using a murine transplantation model in vivo and on cellular survival in vitro were examined.
HAYASHI, Masanobu, ISHIHARA, Yuusuke, 9420, 5056, 5057, 5058, 5059, ENDO, Daiji, 5060, 遠藤, 大二, OKUI, Toyo, HORIGUCHI, Noboru, HIRAI, Ryou, 4569   +13 more
core  

TDMQ20 as A Drug Candidate for Wilson’s Disease: Comparison with D-Penicillamine, Trientine, and Tetrathiomolybdate In Vitro and In Mice

Pharmaceutics
Background/Objectives: The lifelong treatment of Wilson’s disease (WD) currently relies on copper chelators with relatively poor metal specificity, which frequently exhibit serious adverse effects.
Yingshan Zhu, Weiling Peng, Guangwei Liu, Longxin Li, Zikang Zhou, Michel Nguyen, Anne Robert, Yan Liu, Bernard Meunier   +8 more
doaj   +1 more source

Wilson's disease: an analysis of 28 Brazilian children

Clinics, 2012
OBJECTIVES: Clinical-laboratory and evolutionary analysis of twenty-eight patients with Wilson's disease. METHODS: Twenty-eight children (twelve females and sixteen males) with Wilson's disease were evaluated retrospectively between 1987 and 2009, with a
Rodolpho Truffa Kleine, Renata Mendes, Renata Pugliese, Irene Miura, Vera Danesi, Gilda Porta   +5 more
doaj   +1 more source

Evaluation of the efficacy of d-penicillamine and trientine as copper chelators using an in vitro technique involving ovine red blood cells [PDF]

, 1992
The articles have been scanned in colour with a HP Scanjet 5590; 600dpi. Adobe Acrobat XI Pro was used to OCR the text and also for the merging and conversion to the final presentation PDF-format.An in vitro technique for haemolysing ovine red blood ...
Swan, Gerry E., Botha, C.J. (Christoffel Jacobus), Naude, T.W.   +2 more
core  

Trientine: A Very Short Introduction

Commercial and some pharmacological aspects of the copper chelating agent triethylenetetramine (trientine) are discussed in this presentation.
Rupert Purchase (16039694)
core  

Figure S2 from Copper Chelation as Targeted Therapy in a Mouse Model of Oncogenic BRAF-Driven Papillary Thyroid Cancer

, 2018
Supplementary Figure 2. Trientine reduces anchorage-independent growth of BCPAP cells.
Christopher M. Counter (9750248), Michael Casio (15012000), Julie A. Sosa (3045735), MengMeng Xu (252578), Danielle E. Range (15012003)   +4 more
core   +1 more source