Results 61 to 70 of about 2,712 (224)

Reactive oxygen-derived free radicals are key to the endothelial dysfunction of diabetes. [PDF]

, 2009
Vascular complications are an important pathological issue in diabetes that lead to the further functional deterioration of several organs. The balance between endothelium-dependent relaxing factors and endothelium-dependent contracting factors (EDCFs ...
Afkhami-Ardekani, Akamine, Altan, Aragno, Arcaro, Arvola, Auch-Schwelk, Belmadani, Bohlen, Boveris, Burnham, Busse, Ceriello, Chen, Clarkson, Cohen, Cosentino, Crabtree, De Vriese, De Vriess, Ding, Enderle, Feletou, Feletou, Feletou, Frustaci, Fu, Fukao, Furchgott, Gao, Garland, Ge, Gebremedhin, Giugliano, Glocker, Gluais, Gluais, Goff, Haidara, Hamaty, Harris, Head, Heygate, Huszka, Huvers, Inkster, Inoguchi, Johnstone, Kagota, Kamata, Kanie, Karasu, Katusic, Katusic, Kedziora-Kornatowska, Keegan, Kocak, Kontos, Lagaud, Lambert, Landmesser, Lassegue, Lekakis, Ling, Liu, Liu, Long, Lüscher, Lüscher, MacKenzie, Makimattila, Makimattila, Makino, Maritim, Martin, Matoba, Matoba, Matsumoto, Matsumoto, Matsumoto, Matsumoto, Matsumoto, Matsumoto, McVeigh, Moien-Afshari, Moncada, Moncada, Moncada, Morikawa, Mulhern, Nagao, Nitenberg, Okon, Olmos, Oniki, Pannirselvam, Pannirselvam, Park, Pieper, Pieper, Qian, Rabini, Raij, Rand, Rizzo, Rodriguez-Mänas, Romero, Rota, Rubanyi, San Martin, Sesso, Shemyakin, Shen, Shen, Shi, Shi, Shi, Shimokawa, Shimokwa, Shinbori, Smits, Spitaler, Su, Tang, Taniguchi, Tesfamariam, Tesfamariam, Tesfamariam, Thollon, Title, Trachte, Triggle, Turner, Vallejo, Vanhoutte, Vanhoutte, Vanhoutte, Vanhoutte, Vignini, Waldron, Waldron, Walker, Ward, Wei, West, Wigg, Yada, Yang, Yang, Yang, Yu, Zenere, Zhang   +152 more
core   +1 more source

From Radiocopper to Cold Copper: Mechanistic Modeling and Simulation to Define Clinical Response Criteria and Biomarkers for VTX‐801 in Wilson Disease

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 1, January 2026.
ABSTRACT We developed a comprehensive, mechanistic model of human copper metabolism to support biomarker qualification for VTX‐801, an adeno‐associated vector‐based gene therapy which is being developed to restore the mutated ATP7B copper transporter gene in Wilson disease (WD). The model integrates physiological copper kinetics with pathophysiological
Andreas Lindauer, Bernard Benichou, Gloria González Aseguinolaza, Jean‐Philippe Combal   +3 more
wiley   +1 more source

[Wilson's disease] [PDF]

, 2006
http://www.huveaux.fr/fr_santesite.aspWilson's disease is an autosomal recessive disorder of copper excess. This illness results from mutations of the ATP7B gene chromosome 13.
Chapuis, Philippe, Duclos-Vallée, Jean-Charles, Ichaï, Philippe, Misrahi, Micheline, Woimant, France   +4 more
core   +1 more source

Methanobactin rapidly facilitates biliary copper excretion in a Wilson disease rat model visualised by 64Cu PET/MRI

British Journal of Pharmacology, Volume 183, Issue 2, Page 268-279, January 2026.
Background and Purpose Methanobactins are peptides with high copper affinity and potential to treat Wilson disease. We examined how two methanobactins (ARBM101 and MB‐OB3b) affected copper handling in the LPP Atp7b−/− Wilson disease rat model, compared to penicillamine or saline, by 64Cu positron emission tomography/magnetic resonance imaging ...
Emilie Munk Lynderup, Mikkel Holm Vendelbo, Frederik Teicher Kirk, Karina Højrup Vase, Aage Kristian Olsen Alstrup, Tamara Rieder, Alan A. DiSpirito, Jeremy D. Semrau, Tea Lund Laursen, Peter Ott, Hans Zischka, Thomas Damgaard Sandahl   +11 more
wiley   +1 more source

Rapid copper acquisition by developing murine mesothelioma: decreasing bioavailable copper slows tumor growth, normalizes vessels and promotes T cell infiltration. [PDF]

PLoS ONE, 2013
Copper, an essential trace element acquired through nutrition, is an important co-factor for pro-angiogenic factors including vascular endothelial growth factor (VEGF).
Andrew Crowe, Connie Jackaman, Katie M Beddoes, Belinda Ricciardo, Delia J Nelson   +4 more
doaj   +1 more source

Truncating mutations in the Wilson disease gene ATP7B are associated with very low serum ceruloplasmin oxidase activity and an early onset of Wilson disease [PDF]

, 2010
Background Mutations in the gene ATP7B cause Wilson disease, a copper storage disorder with a high phenotypic and genetic heterogeneity. We aimed to evaluate whether 'severe' protein-truncating ATP7B mutations (SMs) are associated with low serum ...
Uta Merle, Karl Heinz Weiss, Christoph Eisenbach, Sabine Tuma, Peter Ferenci, Wolfgang Stremmel   +5 more
core   +1 more source

Plasma Glial Fibrillary Acidic Protein Correlates With Brain Metal Burden in Wilson's Disease

Annals of Clinical and Translational Neurology, Volume 12, Issue 12, Page 2433-2445, December 2025.
ABSTRACT Objective Neuroinflammation driven by extracellular copper contributes to neuronal damage in Wilson's disease (WD). This study investigated the relationship between brain metal burden and peripheral neuroinflammation markers in WD. Methods We conducted a cross‐sectional study involving 89 participants, including patients with WD (n = 63 ...
Sung‐Pin Fan, Ya‐Fang Chen, Cheng‐Hsuan Li, Yih‐Chih Kuo, Ni‐Chung Lee, Yin‐Hsiu Chien, Wuh‐Liang Hwu, Tai‐Chung Tseng, Tung‐Hung Su, Chien‐Ting Hsu, Huey‐Ling Chen, Chin‐Hsien Lin, Yen‐Hsuan Ni   +12 more
wiley   +1 more source

A case of trientine overdose

Toxicology International, 2015
Wilson disease is a rare genetic hepatic and neurological disorder of copper accumulation. Trientine is usually used as a second line in the management of patients with this condition. We present a case of a large overdose of Trientine (60 g) resulting in self-limiting dizziness and vomiting with no further clinical sequelae or significant biochemical ...
Hashim, Ahmed, Parnell, Nick
openaire   +3 more sources

COL6A2: A Key Survival‐Related Gene and Restricting Antitumor Immunity in Glioblastoma

Cancer Science, Volume 116, Issue 12, Page 3487-3502, December 2025.
Targeting COL6A2 enhances the activation of dendritic cells and anti‐tumor immunity in glioblastoma multiforme (GBM). COL6A2 may act as a key mediator of immune escape in GBM and a potential target for combinatorial immunotherapeutic strategies. ABSTRACT Glioblastoma (GBM) is an aggressive malignant brain tumor, characterized by a poor prognosis and a ...
Zhenkun Yang, Jiao Meng, Daxing Xu, Jie Li, Fan Kong, Ying Yin, Bo Zhang, Yunhui Pan, Jiantong Jiao, Xinyi Jiang, Zhening Pu   +10 more
wiley   +1 more source

Medical treatment of dystonia [PDF]

, 2016
Therapeutic strategies in dystonia have evolved considerably in the past few decades. Three major treatment modalities include oral medications, botulinum toxin injections and surgical therapies, particularly deep brain stimulation.
Pichet Termsarasab, Steven J. Frucht, Thananan Thammongkolchai   +2 more
core   +2 more sources