Results 51 to 60 of about 1,630 (179)
Brain and Behavior, Volume 16, Issue 8, August 2026.ABSTRACT Background Wilson's disease (WD) is an autosomal recessive disorder of copper metabolism with heterogeneous hepatic and neurological manifestations. Autonomic nervous system (ANS) involvement in WD is poorly recognized and remains inadequately studied, despite its potential to cause significant morbidity if unrecognized.
Sabyasachi Pattanayak +14 more
wiley +1 more source
Ayurvedic approach for management of Wilson's disease: A case report
Journal of Ayurveda and Integrative Medicine, 2020 Wilson's disease betides due to mutation in ATP-7B that leads to snagging in copper transport by the hepatic lysosomes resulted in the deposition of copper in the brain, liver, kidney or skeletal system. The symptoms are jaundice, edema in legs, ascites,
Tarun Kumar, Anup Thakar
doaj +1 more source
Advances in Treatment of Wilson Disease
Tremor and Other Hyperkinetic Movements, 2018 Background: Wilson disease (WD) is an inherited neurometabolic disorder that results in excessive copper deposition in the liver and the brain, affecting children and young adults. Without treatment the disease is invariably fatal.
Annu Aggarwal, Mohit Bhatt
doaj +1 more source
Advanced Science, Volume 13, Issue 32, 9 June 2026.A mitochondria‐targeted copper depletion nanoplatform (CYN‐CDA@Alb) was developed to selectively disrupt tumor mitochondria copper, which then reprogrammed the tumor immune microenvironment by depressing PD‐L1 and CD47 expression simultaneously. By doing this, CYN‐CDA@Alb reversed radiotherapy‐induced immune tolerance, showing the potential usage of ...
Zaigang Zhou +10 more
wiley +1 more source
Exploring and Targeting the Connection of Iron and Copper Homeostasis to Neurodegenerative Diseases
MedComm, Volume 7, Issue 6, June 2026.Iron and copper dyshomeostasis, along with their interactions with key intrinsically disordered proteins (e.g., Aβ, tau, α‐synuclein) have a strong implication in the onset and progression of neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), Prion diseases (PrDs), Huntington's disease (HD), Wilson's disease (WD),
Xin Liu +9 more
wiley +1 more source
Rapid copper acquisition by developing murine mesothelioma: decreasing bioavailable copper slows tumor growth, normalizes vessels and promotes T cell infiltration. [PDF]
PLoS ONE, 2013 Copper, an essential trace element acquired through nutrition, is an important co-factor for pro-angiogenic factors including vascular endothelial growth factor (VEGF).
Andrew Crowe +4 more
doaj +1 more source
The Challenge of Adherence in Wilson Disease: An Opportunity for Nurse‐Led Interventions
Liver International, Volume 46, Issue 5, May 2026.ABSTRACT Background and Aims Life‐long treatment is critical in Wilson disease (WD), a rare genetic disease leading to copper accumulation with hepatic and extrahepatic manifestations. Poor adherence is a well‐known contributor to unfavourable clinical outcomes.
Anna Miralpeix +8 more
wiley +1 more source
Hepatic Lenticular Degeneration With Renal Tumors: A Case Series
Clinical Case Reports, Volume 14, Issue 1, January 2026.ABSTRACT This article presents a series of cases involving hepatic lenticular degeneration (Wilson's disease) complicated by renal tumors. It details the clinical manifestations, diagnostic procedures, treatment strategies, pathological features and outcomes of these patients. We found that this type of patient has an early‐onset disease, complex tumor
Haibing Xiao +9 more
wiley +1 more source
Uptake Mechanism of Trientine by Rat Intestinal Brush-border Membrane Vesicles
, 1996 The uptake characteristics of trientine by rat intestinal brush-border membrane vesicles were studied. The uptake characteristics of trientine were similar to those of the physiological polyamines with respect to the excessive accumulation
Ryou Tanabe +4 more
core +1 more source