Results 41 to 50 of about 2,712 (224)
Romanian Journal of Neurology, 2011 A disturbance of copper metabolism causes hepatolenticular degeneration (Wilson’s disease), an autosomal recessive disorder whose genetic locus lies on the long arm of chromosome 13.
A. Hancu +5 more
doaj +1 more source
Switching Pharmacological Treatment in Wilson Disease: Case Report and Recommendations
Journal of Investigative Medicine High Impact Case Reports, 2020 Background . Available treatments for Wilson disease (WD) prevent longterm complications of copper accumulation. Current anti-copper agents include zinc salts, penicillamine, and trientine.
Marcia Leung MD +2 more
doaj +1 more source
Synthetic, Crystallographic, and Computational Study of Copper(II) Complexes of Ethylenediaminetetracarboxylate Ligands [PDF]
, 2013 Copper(II) complexes of hexadentate ethylenediaminetetracarboxylic acid type ligands H4eda3p and H4eddadp (H4eda3p = ethylenediamine-N-acetic-N,N′,N′-tri-3-propionic acid; H4eddadp = ethylenediamine-N,N′-diacetic-N,N′-di-3-propionic acid) have been ...
Cendic, Marina +8 more
core +4 more sources
Pharmaceuticals, 2021 The platinum (Pt)-containing antitumor drugs including cisplatin (cis-diamminedichloroplatinum II, cDDP), carboplatin, and oxaliplatin, have been the mainstay of cancer chemotherapy. These drugs are effective in treating many human malignancies.
Macus Tien Kuo +3 more
doaj +1 more source
Targeted PI3K/AKT/mTOR therapy for metastatic carcinomas of the cervix: A phase I clinical experience. [PDF]
, 2014 BackgroundActivated PI3K/AKT/mTOR pathway frequently occurs in metastatic or recurrent cervical carcinomas. However, the clinical benefits of matched therapy, a therapeutic approach targeting a specific mutational abnormality, have not yet been ...
Coleman, Robert L +11 more
core +3 more sources
Cuproplasia and cuproptosis, two sides of the coin. [PDF]
Cancer Commun (Lond)Abstract Copper is an essential micronutrient in the human body, mainly acting as a crucial cofactor required for a wide range of physiological processes across nearly all cell types. Recent advances revealed that tumor cells seize copper to fulfill their rapid proliferation, metastasis, immune evasion, and so on by reprogramming the copper regulatory ...
Lu K, Wijaya CS, Yao Q, Jin H, Feng L.
europepmc +2 more sources
Wilson disease in Northern Portugal: a long-term follow-up study
Orphanet Journal of Rare Diseases, 2022 Introduction Wilson disease is an autosomal recessive disease of liver copper metabolism with predominant hepatic and neurological manifestations. Long-term data on the clinical follow-up and treatment efficacy are limited due to the low frequency of the
Isabel Garrido +5 more
doaj +1 more source
Pediatric liver diseases: current challenges and future perspectives [PDF]
, 2015 Chronic liver diseases in children represent a rising problem with significant effects on public health. In fact, several pediatric liver diseases are precursors of adult chronic hepatopathies, cirrhosis and hepatocellular carcinoma.
Alisi, Anna +5 more
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Copper excess, zinc deficiency, and cognition loss in Alzheimer's disease [PDF]
, 2012 In this special issue about biofactors causing cognitive impairment, we present evidence for and discuss two such biofactors. One is excess copper, causing neuronal toxicity. The other is zinc deficiency, causing neuronal damage. We present evidence that
Cristina Polidori, Maria
core +1 more source