Results 181 to 190 of about 22,737 (222)

MyD88 Contributes to TLR3-Mediated NF-κB Activation and Cytokine Production in Macrophages. [PDF]

Cells
Chai Z, Zhou Y, Yang L, Zhang Y, Hossain S, Hajimirzaei S, Qi J, Zhang G, Wei Y, Li Z.   +9 more
europepmc   +1 more source

Anti-Inflammatory Effects of Pingyin Rose Essential Oil in LPS-Induced HaCaT Cells: An in Vitro and in Silico Study. [PDF]

Int J Mol Sci
Song J, Raka RN, Zhang Z, Xiao J, Huang M, Wu H.   +5 more
europepmc   +1 more source

MAP Crosslinker Chirality Regulates Macrophage Polarization Through MD-2 Engagement and Enables Tunable Immunomodulation Through Novel Peptide Design. [PDF]

Adv Healthc Mater
Suarez-Arnedo A, Thomas JL, Liu Y, Cordero-Alvarado P, Kim A, Espinoza AC, Harvey L, Poysungnoen K, Lin F, Ye Z, Segura T.   +10 more
europepmc   +1 more source

IRAK2 deficiency causes immune dysregulation through defective Myddosome assembly and enhanced interferon responses. [PDF]

Nat Commun
Fei Y, Liu L, Ma S, Jin Y, Wang S, Zhang L, Yang J, Liu Y, Lu M, Xue J, Li J, Chen X, Wang J, Yao Y, Liu C, Zhang J, Han X, Fu J, Kang Z, Wang Y, Sun X, Zhang C, He T, Liu Z, Guo L, Chen C, Zhao H, Gao X, Zhong H, Wen L, Yu X, Liu Z, Zhou Q.   +32 more
europepmc   +1 more source

WDFY 1 mediates TLR 3/4 signaling by recruiting  TRIF [PDF]

EMBO Reports, 2015
Toll-like receptors (TLRs) are pattern recognition receptors that sense a variety of pathogens, initiate innate immune responses, and direct adaptive immunity. All TLRs except TLR3 recruit the adaptor MyD88 to ultimately elicit inflammatory gene expression, whereas TLR3 and internalized TLR4 use TIR-domain-containing adaptor TRIF for the induction of ...
Shuai Wang, Hong-Bing Shu, Yun-Hong Hu   +2 more
exaly   +6 more sources

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Suppression of the TRIF‐dependent signaling pathway of TLRs by epoxomicin

Archiv der Pharmazie, 2021
AbstractToll‐like receptors (TLRs) can recognize specific signatures of invading microbial pathogens and activate a cascade of downstream signals to induce the secretion of inflammatory cytokines, chemokines, and type I interferons. The activation of TLRs triggers two downstream signaling pathways: the MyD88‐ and the TRIF‐dependent pathways.
Su Y. Kim, Seokwon Shin, Minji Kwon, Daniel Youn, Nam J. Sung, Na H. Kim, Sin‐Aye Park, Hyung‐Sun Youn   +7 more
openaire   +2 more sources

Telomerization of octamethylcyclotetrasiloxane with dichloromethyl (3,3,3-trif luoropropyl) silane and with chlorotris (3,3,3-trif luoropropyl) silane

Bulletin of the Academy of Sciences, USSR Division of Chemical Science, 1966
1. The telomerization of octamethylcyclotetrasiloxane with fluorinated alkylchlorosilanes was investigated for the first time. The telomerization of octamethylcyclotetrasiloxane with dichloromethyl (3,3,3-trifluoropropyl) silane and with chlorotris (3,3,3-trifluoropropyl) silane leads to the formation of linear structure. 2.
V. A. Ponomarenko, N. M. Khomutova
openaire   +1 more source

Upregulation of costimulatory molecules induced by lipopolysaccharide and double-stranded RNA occurs by Trif-dependent and Trif-independent pathways

Nature Immunology, 2003
Both lipopolysaccharide (LPS) and double-stranded RNA (dsRNA) are adjuvants for the adaptive immune response, inducing upregulation of costimulatory molecules (UCM) on antigen-presenting cells. Trif, an adapter protein that transduces signals from Toll-like receptor 4 (TLR4) and TLR3, permits the induction of many cytokines, including interferon-beta ...
Hoebe, K., Janssen, E. M., Kim, S. O., Alexopoulou, L., Flavell, R. A., Han, J. H., Beutler, B.   +6 more
openaire   +3 more sources

TLR4 as a TRIF-biased receptor (P1212)

The Journal of Immunology, 2013
Abstract We reported previously that the vaccine adjuvant monophosphoryl lipid A (MPLA) could behave as a TRIF-biased agonist of TLR4, with mostly intact TRIF-dependent outcomes but less MyD88/TRIF co-dependent activation of proinflammatory cytokines, and proposed that TRIF-bias was an important component of MPL’s success as a clinically
Joseph Kolb, Carolyn Casella, Shuvasree SenGupta, Thomas Mitchell   +3 more
openaire   +1 more source

2-Trif luoromethyl-4H-thiochromen-4-one and 2-trif luoromethyl-4H-thiochromene-4-thione: Synthesis and reactivities

Russian Chemical Bulletin, 2006
2-Trifluoromethyl-4H-thiochromene-4-thione obtained from 2-trifluoromethyl-4H-thiochromen-4-one and P2S5 reacts with aromatic amines, hydrazine hydrate, phenylhydrazine, and hydroxylamine at the C(4) atom of the chromene ring to give the corresponding anils, azine, hydrazones, and oxime of thiochromone.
B. I. Usachev, M. A. Shafeev, V. Ya. Sosnovskikh   +2 more
openaire   +1 more source