Recommendations to Improve Outcomes in Acne and Acne Sequelae: A Focus on Trifarotene and Other Retinoids [PDF]
Dermatology and TherapyAcne vulgaris affects nearly 50 million people in the USA, ranking as the eighth most prevalent disease globally. This chronic inflammatory skin condition often results in sequelae, including atrophic acne scars, acne-induced macular erythema and acne ...
Naiem Issa +15 more
doaj +5 more sources
Comparison of the Efficacy of Clascoterone, Trifarotene, and Tazarotene for the Treatment of Acne: A Systematic Literature Review and Meta-Analysis [PDF]
Dermatology and TherapyIntroduction Acne vulgaris, a chronic inflammatory condition, is associated with significant physical and psychosocial burden. Since 2019, three new topical agents for acne vulgaris have been approved in the USA and Canada.
Mahek Shergill +2 more
doaj +3 more sources
Bridging Gaps in Malaysian Acne Vulgaris Guidelines: Advisory Statements on Trifarotene for Facial and Truncal Acne [PDF]
Journal of Cosmetic DermatologyABSTRACT Background Trifarotene, a fourth‐generation topical retinoid, offers a novel therapeutic option for facial and truncal acne. However, its role was only briefly addressed in Malaysia's 2022 Clinical Practice Guidelines (CPGs) due to its unavailability at the time.
Zhenli Kwan +2 more
exaly +3 more sources
Successful Trifarotene Treatment of a Typical Kyrle's Disease With Overview of Topical Therapies. [PDF]
Skin Res TechnolABSTRACT Kyrle's disease is a rare skin disorder involving transepidermal keratin elimination, usually linked to systemic illness. We report a unique case—a healthy 26‐year‐old man resistant to standard therapy. Remission was achieved with daily topical trifarotene 0.005% over eight weeks.
Kruczek W +7 more
europepmc +3 more sources
The Next Generation of Skin Care: Transforming Retinoid Therapeutics [PDF]
CellsRetinoids are central regulators of skin biology, influencing keratinocyte proliferation, differentiation, immune modulation, and barrier maintenance.
Julia Weronika Łuczak +7 more
doaj +2 more sources
Divergent System Organ Class Safety Profiles of Isotretinoin Versus Topical Retinoids: An EudraVigilance Disproportionality Analysis [PDF]
PharmaceuticalsBackground/Objectives: Isotretinoin remains an essential therapy for severe acne, yet its safety profile continues to raise concerns. This study analyzed adverse event reporting patterns for isotretinoin versus topical retinoids using EudraVigilance data.
Denisa Viola Szilagyi +7 more
doaj +2 more sources
Dermatology and Therapy, 2020 There is a paucity of literature covering patient-reported outcomes of treatments for truncal acne. Trifarotene 50 μg/g cream is a novel retinoid molecule approved for once-daily topical treatment of facial and truncal acne vulgaris.
Sandra Johnson, Rajeev Chavda
exaly +2 more sources
Exploring the role of trifarotene against RAR-α: an investigation of expression pattern and clinicopathological significance of RAR-α in breast cancer [PDF]
Frontiers in PharmacologyIntroductionThe members retinoic acid receptors (RARs) (α, β, and γ) and retinoid X receptors (RXRs) (α, β, and γ) belong to the retinoid receptor family.
Nusrat Jan +7 more
doaj +2 more sources
Trifarotene alleviates skin photoaging injury by inhibition of JNK/c-Jun/MMPs [PDF]
Acta PharmaceuticaLong-term exposure to ultraviolet (UV) radiation induces skin photoaging, which manifests as oxidative stress, inflammation, and collagen degradation. Multiple approaches (topical or systemic retinoids, antioxidants, alpha-hydroxy acids, laser, surgery ...
Fei Xuan +8 more
doaj +6 more sources
Skin-Colored Papules on the Neck of a Postmenopausal Woman: A Diagnostic Challenge [PDF]
DermatopathologyA 64-year-old patient presented for management of symptomatic skin-colored papules symmetrically distributed over the lateral neck over the past two years, which failed to improve on multiple topical corticosteroids, antifungal creams, and topical ...
Jason El Jalkh +4 more
doaj +2 more sources