Divergent System Organ Class Safety Profiles of Isotretinoin Versus Topical Retinoids: An EudraVigilance Disproportionality Analysis [PDF]
PharmaceuticalsBackground/Objectives: Isotretinoin remains an essential therapy for severe acne, yet its safety profile continues to raise concerns. This study analyzed adverse event reporting patterns for isotretinoin versus topical retinoids using EudraVigilance data.
Denisa Viola Szilagyi +7 more
doaj +3 more sources
Pharmaceutics, 2019 Acne vulgaris is a common inflammatory pilosebaceous condition that affects 80−90% of adolescents. Since the introduction of tretinoin over 40 years ago, topical retinoid products have been a mainstay of acne treatment.
Heather Benson +2 more
exaly +4 more sources
Topical and Systemic Retinoids in the Management of Hidradenitis Suppurativa: A Comprehensive Literature Review [PDF]
Dermatology and TherapyHidradenitis suppurativa (HS) is a debilitating chronic skin disorder characterized by painful inflammatory nodules, abscesses and sinus tracts involving intertriginous areas and has an adverse impact on patient quality of life. Over the past decade, the
Annamaria Offidani +2 more
exaly +4 more sources
Topical Retinoids in Acne Vulgaris and Acne Scars—From Monotherapy to Combining Regimens [PDF]
PharmaceuticalsTopical retinoids are the cornerstone of the treatment of multiple dermatological conditions. Long established in acne therapy, they exert effects on keratinization, inflammation, fibroblast activity, and collagen remodeling, suggesting a potential role ...
Aleksandra Tobiasz +2 more
doaj +2 more sources
Topical retinoids and risk of major congenital malformations and spontaneous abortion: a systematic review and meta-analysis [PDF]
Frontiers in Drug Safety and RegulationBackgroundTopical retinoids are commonly prescribed for dermatological conditions during reproductive years; however, concerns regarding teratogenicity have persisted due to the established risks associated with oral retinoids. This systematic review and
Alaa Baqer Alali +9 more
doaj +2 more sources
Racial differences in tolerability of topical retinoids: A 15-year single-center retrospective cohort study [PDF]
JAAD InternationalHye Jin Chung
exaly +2 more sources
Optimizing the use of topical retinoids in Asian acne patients [PDF]
Journal of Dermatology, 2018 Nobukazu Hayashi
exaly +2 more sources
Advances in Skin Whitening Agents: Mechanisms, Clinical Applications, and Future Perspectives [PDF]
J Cosmet DermatolABSTRACT Background Skin hyperpigmentation disorders are common cosmetic and clinical concerns caused by excessive melanin production, abnormal pigment distribution, or persistent pigment after inflammation. Their heterogeneous pathogenesis and tendency to recur complicate treatment, particularly in patients with darker phototypes.
Chen Y +7 more
europepmc +2 more sources
Topical Epidermal Growth Factor in Acne Vulgaris and Acne‐Related Sequelae: Mechanistic Rationale, Clinical Evidence, and Formulation Challenges [PDF]
J Cosmet DermatolABSTRACT Background Acne vulgaris (AV) is a common chronic inflammatory skin disorder, particularly among adolescents and young adults, and its management remains limited by variable treatment response, poor adherence, and treatment‐related adverse effects.
Gholizadeh N +7 more
europepmc +2 more sources
Retinoids for prevention and treatment of actinic keratosis [PDF]
Anais Brasileiros de Dermatologia, 2013 Actinic keratosis is a common cause of dermatological consultations and it presents a strong association with squamous cell carcinoma. Many substances are used for treatment and prevention, such as retinoids.
Mayra Ianhez +3 more
doaj +1 more source