Results 11 to 20 of about 737 (161)

Deoxygenative trifluoromethylthiolation of carboxylic acids [PDF]

Chemical Science, 2019
A deoxygenative trifluoromethylthiolation method produces trifluoromethyl thioesters from readily available carboxylic acids.
Runze Mao, Srikrishna Bera, Alexis Cheseaux, Xile Hu   +3 more
openaire   +5 more sources

A General Group Testing Strategy for Discovering Chemical Cooperativity. [PDF]

Angew Chem Int Ed Engl
A combinatorial design theory‐based group testing strategy coupled with luminescence screening to uncover cooperative interactions in a large combinatorial space. Iterative deconvolution identifies reactive molecular pairs and enables the discovery of trifluoromethylthiolation (SCF3) reagents.
Pflüger PM, Katzenburg F, Sandfort F, Teders M, Gómez-Suárez A, Standley EA, Hopkinson MN, Daniliuc CG, Heuer A, Glorius F.   +9 more
europepmc   +3 more sources

Bis(trifluoromethyl)disulfide and the EtP₄ Phosphazene Base-Formation of a Bench-Stable [EtP₄SCF₃]⁺[SCF₃]^- Salt. [PDF]

Chemistry
The synthesis of a bench‐stable trifluoromethylthiolate‐substituted phosphazenium salt is reported. Reaction of bis(trifluoromethyl)disulfide with the EtP4 phosphazene base furnishes this salt in quantitative yield. The compound features a unique trifluoromethylthiolate‐iminium motif and allows for functionalization of both trifluoromethylthiolate ...
Hartmann L, Wels K, Tiessen N, Neumann B, Lamm JH, Stammler HG, Hoge B.   +6 more
europepmc   +2 more sources

Photoredox-Mediated, Nickel-Catalyzed Trifluoromethylthiolation of Aryl and Heteroaryl Iodides [PDF]

, 2021
While the area of trifluoromethylthiolation of aryl halides has been extensively explored, the current methods require complex and/or air-sensitive catalysts. Reported here is a method employing a bench-stable nickel(II) salt and an iridium photocatalyst
Christopher S., Gravatt, Jeffrey W., Johannes, Avipsa, Ghosh   +2 more
core   +2 more sources

Metal Free Synthesis of Seven-Membered Biaryl Sultams. [PDF]

Chem Asian J
A simple, metal‐free denitrogenative cyclization of benzothiatriazines enables efficient access to seven‐membered biaryl sultams under thermal conditions. The reaction tolerates diverse functional groups, and mechanistic studies, including radical trapping and EPR analysis, support a diradical pathway, providing new insights into sultam formation ...
Aman H, Huang BS, Liao JY, Thorat VH, Liao ZY, Liu YH, Yen LT, Hsieh JC, Chuang GJ.   +8 more
europepmc   +2 more sources

Synthesis and Use of Trifluoromethylthiolated Ketenimines [PDF]

Chemistry – A European Journal, 2020
AbstractThe synthesis of trifluoromethylthiolated ketenimines is herein described. They are easily synthesized from the corresponding α‐trifluoromethylthiolated oximes upon activation with triflic anhydride and a base. The presumed nitrilium ion resulting from the Beckmann rearrangement is deprotonated to lead to the key intermediate, whose stability ...
Leroux, Frédéric R., Guérin, Thomas, Pikun, Nadiia, Morioka, Ryutaro, Panossian, Armen, Leroux, Frédéric, Hanquet, Gilles   +6 more
openaire   +3 more sources

Trifluoromethylthiolation of Arenes Using Lewis Acid and Lewis Base Dual Catalysis. [PDF]

J Org Chem
Incorporation of the highly lipophilic trifluoromethanesulfenyl group into bioactive molecules facilitates transport through lipid membranes, and thus, CF3S-containing compounds are important for drug discovery. Although reagents and procedures have been
Waddell LJN, Wilson C, Sutherland A.
europepmc   +3 more sources

Asymmetric Preparation of α-Quaternary Fluorinated β-keto Esters. Review

Molecules, 2020
In this review, recent advances over the past decade in the preparation of fluorinated stereogenic quaternary centers on β-keto esters compounds are analyzed.
Albert Granados, Adelina Vallribera
doaj   +1 more source

Difluorocarbene‐Derived Trifluoromethylthiolation and [¹⁸F]Trifluoromethylthiolation of Aliphatic Electrophiles [PDF]

Angewandte Chemie International Edition, 2015
AbstractThe first trifluoromethylthiolation and [18F]trifluoromethylthiolation of alkyl electrophiles with in situ generated difluorocarbene in the presence of elemental sulfur and external (radioactive) fluoride ion is described. This transition‐metal‐free approach is high yielding, compatible with a variety of functional groups, and operated under ...
Jian, Zheng, Lu, Wang, Jin-Hong, Lin, Ji-Chang, Xiao, Steven H, Liang   +4 more
openaire   +2 more sources

Recent Advances in Bioconjugation of Aromatic Amino Acid Residues by a Reactivity-Guided Approach. [PDF]

Chem Rec
This review highlights recent advances in the bioconjugation of aromatic amino acids residues, focusing on strategies that leverage their inherent chemical reactivity to enable precise and versatile modifications of biomacromolecules, illustrating relevant applications.
Santos BMDS, da Frota LCRM, Silva TG, Finelli FG.   +3 more
europepmc   +2 more sources