Results 21 to 30 of about 9,021 (263)

Role of voltage-gated sodium channels in axonal signal propagation of trigeminal ganglion neurons after infraorbital nerve entrapment

Neurobiology of Pain, 2022
Chronic pain arising from peripheral nerve injuries represents a significant clinical challenge because even the most efficacious anticonvulsant drug treatments are limited by their side effects profile.
Yatendra Mulpuri, Toru Yamamoto, Ichiro Nishimura, Igor Spigelman   +3 more
doaj   +1 more source

Contemporary management of pain in cirrhosis: Toward precision therapy for pain

Hepatology, EarlyView., 2022
Abstract Chronic pain is highly prevalent in patients with cirrhosis and is associated with poor health‐related quality of life and poor functional status. However, there is limited guidance on appropriate pain management in this population, and pharmacologic treatment can be harmful, leading to adverse outcomes, such as gastrointestinal bleeding ...
Alexis Holman, Neehar Parikh, Dan J. Clauw, David A. Williams, Elliot B. Tapper   +4 more
wiley   +1 more source

Evaluation of Sensorimotor Nerve Damage in Patients with Maxillofacial Trauma; a Single Center Experience [PDF]

Bulletin of Emergency and Trauma, 2016
Objective: To evaluate sensorimotor nerve damage in patients with maxillofacial trauma referring to Taleghani hospital, Tehran, IranMethods: This cross-sectional study was conducted during a 2-year period from 2014 to 2012 in Taleghani hospital of Tehran.
Behnaz Poorian, Mehdi Bemanali, Mohammad Chavoshinejad   +2 more
doaj   +2 more sources

Visualization of Inferior Alveolar and Lingual Nerve Pathology by 3D Double-Echo Steady-State MRI: Two Case Reports with Literature Review

Journal of Imaging, 2022
Injury to the peripheral branches of the trigeminal nerve, particularly the lingual nerve (LN) and the inferior alveolar nerve (IAN), is a rare but serious complication that can occur during oral and maxillofacial surgery. Mandibular third molar surgery,
Adib Al-Haj Husain, Daphne Schönegg, Silvio Valdec, Bernd Stadlinger, Thomas Gander, Harald Essig, Marco Piccirelli, Sebastian Winklhofer   +7 more
doaj   +1 more source

Trigeminal Trophic Syndrome: An Exuberant Case

Acta Médica Portuguesa
N/a.
Miguel Santos-Coelho, Mafalda Pestana, Íris M. Brito   +2 more
doaj   +3 more sources

Burkholderia pseudomallei invades the olfactory nerve and bulb after epithelial injury in mice and causes the formation of multinucleated giant glial cells in vitro.

PLoS Neglected Tropical Diseases, 2020
The infectious disease melioidosis is caused by the bacterium Burkholderia pseudomallei. Melioidosis is characterised by high mortality and morbidity and can involve the central nervous system (CNS). We have previously discovered that B. pseudomallei can
Heidi Walkden, Ali Delbaz, Lynn Nazareth, Michael Batzloff, Todd Shelper, Ifor R Beacham, Anu Chacko, Megha Shah, Kenneth W Beagley, Johana Tello Velasquez, James A St John, Jenny A K Ekberg   +11 more
doaj   +1 more source

Intranasal Peptide Therapeutics: A Promising Avenue for Overcoming the Challenges of Traditional CNS Drug Development

Cells, 2022
The central nervous system (CNS) has, among all organ systems in the human body, the highest failure rate of traditional small-molecule drug development, ranging from 80–100% depending on the area of disease research.
Meenakshi Bose, Gabriela Farias Quipildor, Michelle E. Ehrlich, Stephen R. Salton   +3 more
doaj   +1 more source

Sex Difference in Trigeminal Neuropathic Pain Response to Exercise: Role of Oxidative Stress

Pain Research and Management, 2020
Aim. Orofacial chronic neuropathic pain commonly occurs following trigeminal nerve injuries. We investigated whether swimming exercise can reduce trigeminal neuropathic pain through improving antioxidant capacity. Materials and Methods.
Zahra Rostami, Sahar Ghasemi, Hamed Farzadmanesh, Manouchehr Safari, Ali Ghanbari   +4 more
doaj   +1 more source

Multiple Morphometric Assessment of Microglial Cells in Deafferented Spinal Trigeminal Nucleus

Frontiers in Neuroanatomy, 2020
Microglia (MG) are the first cells to react to the abnormal incoming signals that follow an injury of sensory nerves and play a critical role in the development and maintenance of neuropathic pain, a common sequel of nerve injuries.
Nuria García-Magro, Nuria García-Magro, Yasmina B. Martin, Alejandra Palomino-Antolin, Javier Egea, Pilar Negredo, Carlos Avendaño   +6 more
doaj   +1 more source

Targeting the ARRDC3–DRP1 Axis via hUMSC‐Derived Exosomal CRYAB for Neuroprotection in Cerebral Ischemia/Reperfusion Injury

Advanced Healthcare Materials, EarlyView.
Intranasally administered hUMSC‐derived exosomes modulate the CRYAB–ARRDC3–Drp1 axis, alleviating mitochondrial dysfunction and ferroptosis, enhancing neuronal survival, reducing oxidative stress, and promoting functional recovery in ischemia‐reperfusion injury, offering a promising therapeutic strategy for ischemic stroke.
Rong ji, Zengyu Zhang, Zhuohang Liu, Kaicheng Yang, Xueyu Mao, Min Chu, Yong Wang, Jing Zhao   +7 more
wiley   +1 more source