Results 21 to 30 of about 8,937 (232)

The Effectiveness of Trigeminal Nerve Stimulation on Traumatic Brain Injury [PDF]

Neuromodulation: Technology at the Neural Interface, 2022
Trigeminal nerve stimulation (TNS) is a promising strategy in treating diseases of the nervous system. In this study, the effects of TNS on traumatic brain injury (TBI) were investigated in a mouse model.TBI was induced using a weight-drop device, and TNS treatment was delivered in the first hour after the TBI.
Qian, Yang, Subo, Zhang, Zhen, Xu, Lijiaqi, Liu, Shengnuo, Fan, Shaoling, Wu, Chao, Ma   +6 more
openaire   +2 more sources

Trigeminal Trophic Syndrome: An Exuberant Case

Acta Médica Portuguesa
N/a.
Miguel Santos-Coelho, Mafalda Pestana, Íris M. Brito   +2 more
doaj   +3 more sources

Burkholderia pseudomallei invades the olfactory nerve and bulb after epithelial injury in mice and causes the formation of multinucleated giant glial cells in vitro.

PLoS Neglected Tropical Diseases, 2020
The infectious disease melioidosis is caused by the bacterium Burkholderia pseudomallei. Melioidosis is characterised by high mortality and morbidity and can involve the central nervous system (CNS). We have previously discovered that B. pseudomallei can
Heidi Walkden, Ali Delbaz, Lynn Nazareth, Michael Batzloff, Todd Shelper, Ifor R Beacham, Anu Chacko, Megha Shah, Kenneth W Beagley, Johana Tello Velasquez, James A St John, Jenny A K Ekberg   +11 more
doaj   +1 more source

Sex Difference in Trigeminal Neuropathic Pain Response to Exercise: Role of Oxidative Stress

Pain Research and Management, 2020
Aim. Orofacial chronic neuropathic pain commonly occurs following trigeminal nerve injuries. We investigated whether swimming exercise can reduce trigeminal neuropathic pain through improving antioxidant capacity. Materials and Methods.
Zahra Rostami, Sahar Ghasemi, Hamed Farzadmanesh, Manouchehr Safari, Ali Ghanbari   +4 more
doaj   +1 more source

Intranasal Peptide Therapeutics: A Promising Avenue for Overcoming the Challenges of Traditional CNS Drug Development

Cells, 2022
The central nervous system (CNS) has, among all organ systems in the human body, the highest failure rate of traditional small-molecule drug development, ranging from 80–100% depending on the area of disease research.
Meenakshi Bose, Gabriela Farias Quipildor, Michelle E. Ehrlich, Stephen R. Salton   +3 more
doaj   +1 more source

Diagnosis of the Trigeminal Nerve Injury in a Patient with Pontine Hemorrhage [PDF]

Diagnostics, 2020
Herein, we present a patient who was diagnosed with trigeminal nerve injury following a pontine hemorrhage. A 38-year-old male was diagnosed with a left pontine hemorrhage and underwent conservative management at the neurosurgery department of a university hospital. After hemorrhage onset, he felt facial pain on the right side.
Eun Bi Choi, Jeong Pyo Seo, Sung Ho Jang
openaire   +3 more sources

Multiple Morphometric Assessment of Microglial Cells in Deafferented Spinal Trigeminal Nucleus

Frontiers in Neuroanatomy, 2020
Microglia (MG) are the first cells to react to the abnormal incoming signals that follow an injury of sensory nerves and play a critical role in the development and maintenance of neuropathic pain, a common sequel of nerve injuries.
Nuria García-Magro, Nuria García-Magro, Yasmina B. Martin, Alejandra Palomino-Antolin, Javier Egea, Pilar Negredo, Carlos Avendaño   +6 more
doaj   +1 more source

Circular RNA circNrip1 Interacts with SYNCRIP to Promote Neuropathic Pain by Stabilizing Tlr2 mRNA in Primary Sensory Neurons

Advanced Science, EarlyView.
Model of circNrip1 (cNrip1) upregulation driving neuropathic pain mechanisms. After peripheral nerve injury, increased FUS triggers the formation and upregulation of cNrip1 in injured DRG neurons. Upregulated cNrip1 recruits SYNCRIP to the 3′‐UTR of Tlr2 mRNA by binding to both, thereby promoting SYNCRIP‐triggered Tlr2 mRNA stability and increasing ...
Xiaozhou Feng, Jifang Xiao, Congcong Huang, Bao‐Chun Jiang, Bing Wang, Xu Li, Shibin Du, Tolga Berkman, Chun‐Hsien Wen, Weihua Cai, Dilip Sharma, Kun Wang, Longfei Ma, Huijuan Hu, Yuan‐Xiang Tao   +14 more
wiley   +1 more source

Nigra‐Subthalamic Dopaminergic Circuitry Modulates and Represents Distinct Pain Modality in Physiological and Pain States in Mice

Advanced Science, EarlyView.
Nigral dopaminergic (DA) neurons modulate and represent pain with a preference to a particular modality (mechanical) and laterality (contralateral), which are controlled by nigral GABAergic neurons. The pain modulation is mimicked by the nigro‐subthalamic projection and its downstream neurons, involving D2‐like receptors.
Ying Ji, Shuyi Li, Jiaqi Zhang, Xiang‐Ying Xu, Cui Yin, Mu Niu, Danyang Liu, Yanyu Jiang, Yong Niu, Su Liu, Bin Zhang, Guiyun Cui, Chunyi Zhou, Cheng Xiao   +13 more
wiley   +1 more source

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source