Results 21 to 30 of about 8,947 (214)

Trigeminal Trophic Syndrome: An Exuberant Case

Acta Médica Portuguesa
N/a.
Miguel Santos-Coelho, Mafalda Pestana, Íris M. Brito   +2 more
doaj   +3 more sources

Burkholderia pseudomallei invades the olfactory nerve and bulb after epithelial injury in mice and causes the formation of multinucleated giant glial cells in vitro.

PLoS Neglected Tropical Diseases, 2020
The infectious disease melioidosis is caused by the bacterium Burkholderia pseudomallei. Melioidosis is characterised by high mortality and morbidity and can involve the central nervous system (CNS). We have previously discovered that B. pseudomallei can
Heidi Walkden, Ali Delbaz, Lynn Nazareth, Michael Batzloff, Todd Shelper, Ifor R Beacham, Anu Chacko, Megha Shah, Kenneth W Beagley, Johana Tello Velasquez, James A St John, Jenny A K Ekberg   +11 more
doaj   +1 more source

Sex Difference in Trigeminal Neuropathic Pain Response to Exercise: Role of Oxidative Stress

Pain Research and Management, 2020
Aim. Orofacial chronic neuropathic pain commonly occurs following trigeminal nerve injuries. We investigated whether swimming exercise can reduce trigeminal neuropathic pain through improving antioxidant capacity. Materials and Methods.
Zahra Rostami, Sahar Ghasemi, Hamed Farzadmanesh, Manouchehr Safari, Ali Ghanbari   +4 more
doaj   +1 more source

Longitudinal Tracking of Astrocyte Reactivity During the Development of Chronic Orofacial Neuropathic Pain Using [¹⁸F]-SMBT-1 Positron-Emission Tomography. [PDF]

Glia
Using [18F]‐SMBT‐1 PET, we longitudinally tracked MAO‐B–expressing reactive astrocytes during orofacial neuropathic pain development in rats, revealing region‐ and time‐specific astrocyte activation during pain chronification. ABSTRACT Chronic neuropathic pain represents a significant global health burden and is hypothesized to be maintained by an ...
Crawford LS, Kang JWM, Davanzo OI, Lim H, Salberg S, Srgo M, Li C, Emvalomenos GM, Jupp B, Long M, Noonan W, Haskali MB, Mychasiuk R, Keay KA, Henderson LA.   +14 more
europepmc   +2 more sources

Intranasal Peptide Therapeutics: A Promising Avenue for Overcoming the Challenges of Traditional CNS Drug Development

Cells, 2022
The central nervous system (CNS) has, among all organ systems in the human body, the highest failure rate of traditional small-molecule drug development, ranging from 80–100% depending on the area of disease research.
Meenakshi Bose, Gabriela Farias Quipildor, Michelle E. Ehrlich, Stephen R. Salton   +3 more
doaj   +1 more source

Diagnosis of the Trigeminal Nerve Injury in a Patient with Pontine Hemorrhage [PDF]

Diagnostics, 2020
Herein, we present a patient who was diagnosed with trigeminal nerve injury following a pontine hemorrhage. A 38-year-old male was diagnosed with a left pontine hemorrhage and underwent conservative management at the neurosurgery department of a university hospital. After hemorrhage onset, he felt facial pain on the right side.
Eun Bi Choi, Jeong Pyo Seo, Sung Ho Jang
openaire   +3 more sources

VDAC1 Upregulation Induces Hyperexcitability of Nociceptive Sensory Neurons Via Enhanced Mitochondrial Atp Efflux in Neuropathic Pain

Advanced Science, EarlyView.
The mechanism diagram of VDAC1 mediating neuronal excitability and neuropathic pain. Briefly, VDAC1 is expressed in DRG neurons and is upregulated following CCI‐induced neuropathic pain. This upregulation enhances ATP transport from mitochondria to the cytoplasm in sensory neurons, leading to increased neuronal excitability and pain behavior.
Fengrun Sun, Ning Yu, Liang Yu, Xiaofen Tian, Yujia Ma, Yikuan Xie, Tao Wang, Chao Ma   +7 more
wiley   +1 more source

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source

Multiple Morphometric Assessment of Microglial Cells in Deafferented Spinal Trigeminal Nucleus

Frontiers in Neuroanatomy, 2020
Microglia (MG) are the first cells to react to the abnormal incoming signals that follow an injury of sensory nerves and play a critical role in the development and maintenance of neuropathic pain, a common sequel of nerve injuries.
Nuria García-Magro, Nuria García-Magro, Yasmina B. Martin, Alejandra Palomino-Antolin, Javier Egea, Pilar Negredo, Carlos Avendaño   +6 more
doaj   +1 more source

HLA‐DR+ Schwann Cells Generate the Protumor Cancer‐Neuron‐Immune Niche in Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
Hijacked and educated by HNSCC cells, HLA‐DR+ Schwann cells lost their normal neural‐related functions but acquired immunoregulatory phenotypes to promote CD4+ T cells transform into Tregs. HLA‐DR+ Schwann cells induced a macrophage subpopulation, Il1β.
Xiaoyan Meng, Zhonglong Liu, Shijian Zhang, Luoman Gan, Liren Cao, Jingjing Sun, Lingfang Zhang, Yue He   +7 more
wiley   +1 more source