Results 91 to 100 of about 273,980 (263)

Pathophysiological Mechanisms of Emaciation Syndrome in Plectropomus leopardus: Insights From Histology and Transcriptomics

Animal Research and One Health, EarlyView.
Integrated phenotypic, histological, transcriptomic, and validation analyses reveal that emaciation syndrome in Plectropomus leopardus is associated with intestinal structural damage, hepatic metabolic remodeling, and muscle protein degradation, highlighting coordinated multi‐tissue alterations underlying disease progression.
Zhihao Zhang, Bo Wang, Mengya Wang, Haizhan Tang, Mingjian Liu, Da Zheng, Zhongyi Zhai, Jiahang Li, Jinyang Xie, Chaofan Jin, Jingjie Hu, Zhenmin Bao   +11 more
wiley   +1 more source

Prognostic value of the triglyceride–glucose index in patients with acute ischemic stroke undergoing endovascular treatment

Journal of International Medical Research
Objective This study aimed to assess the prognostic significance of the triglyceride–glucose index in predicting clinical outcomes in patients with acute ischemic stroke undergoing endovascular thrombectomy.
Ke Yang, Qiwu Xu, Xiangxiang Peng, Xiangjun Xu, Yapeng Guo, Junfeng Xu   +5 more
doaj   +1 more source

Joint association of triglyceride–glucose index and Chinese visceral adiposity index with prevalent diabetes: a cross-sectional study

Frontiers in Endocrinology
BackgroundDiabetes mellitus is strongly associated with insulin resistance and visceral adiposity. Recent studies have demonstrated that the triglyceride–glucose index (TyG) and the Chinese visceral adiposity index (CVAI), which reflect insulin ...
Yuchao Yang, Yuchao Yang, Xiaobing Wu, Deliang Lv, Ziyang Zhang, Fengzhu Xie, Wei Xie, Pan Ke, Hongyun Guan, Xiaoyan Wu, Zhiguang Zhao   +10 more
doaj   +1 more source

Beyond Protein Synthesis: The Multifunctional Role of Functional Amino Acids in Modulating Meat Quality in Ruminants

Animal Research and One Health, EarlyView.
Multifunctional roles of functional amino acids in regulating meat quality in ruminants: Functional amino acids (FAAs) regulate ruminant meat quality through multiple interconnected mechanisms, including antioxidant protection, metabolic regulation, signal transduction, structural support, and gene expression modulation.
Zixin Liu, Tian Xia, Xiaokang Lv, Man Ren, Chuanshe Zhou, Zhiliang Tan   +5 more
wiley   +1 more source

Triglyceride-glucose index: a surrogate marker of homeostasis model assessment of insulin resistance to predict diabetic nephropathy

Journal of the Pakistan Medical Association
Objectives: To determine the association of triglyceride-glucose index with homeostasis model assessment of insulin resistance in type 2 diabetes mellitus patients, and to determine the association of triglyceride-glucose index with urinary albumin-to ...
Sania Khan, Shazia Qayyum, Muhammad Nadim Akbar Khan   +2 more
doaj   +1 more source

Optimizing Efficacy to Safety Ratio of Glucocorticoids in Rheumatoid Arthritis Models by Leveraging Peroxisome Proliferator–Activated Nuclear Receptor‐α Agonism

Arthritis &Rheumatology, EarlyView.
Objective Glucocorticoids remain essential therapies for immune and inflammatory diseases such as rheumatoid arthritis (RA) but are notorious for their metabolic side effects. Given the anti‐inflammatory and metabolically favorable actions of peroxisome proliferator–activated nuclear receptor (PPAR) agonists, we investigated whether PPARα agonism could
Lisa L. Koorneef, Elisabeth Gilis, Dorien Clarisse, Daria Fijalkowska, Sara Dufour, Julie Coudeneys, Bert Luyckx, Annick Verhee, Jonathan Thommis, Candice Vanden Bussche, Ulf Müller‐Ladner, Elena Neumann, Matthias Kerkhofs, Guillaume Planckaert, Simon Devos, Leander Meuris, Dirk Elewaut, Karolien De Bosscher   +17 more
wiley   +1 more source

Non-linear connection between the triglyceride–glucose index and prediabetes risk among Chinese adults: a secondary retrospective cohort study

European Journal of Medical Research
Background The triglyceride–glucose (TyG) index has garnered recognition as a surrogate marker for insulin resistance, a pivotal factor in the pathogenesis of various metabolic disorders.
Changchun Cao, Yong Han, Huanhua Deng, Xiaohua Zhang, Haofei Hu, Fubing Zha, Yulong Wang   +6 more
doaj   +1 more source

Comparison of Triglyceride-Glucose Index Indices and Fatty Liver Index in Predicting Metabolic Dysfunction-Associated Fatty Liver Disease: A Cross-Sectional Study Conducted in Vietnam

Life
Background and Aims: Metabolic dysfunction-associated fatty liver disease (MAFLD) is increasingly prevalent and linked to liver and cardiometabolic complications. Although liver biopsy remains the diagnostic gold standard, its invasiveness limits routine
Linh Nhat Boi Nguyen, Thong Duy Vo
doaj   +1 more source

Durable and Additive Disease Control at 52 Weeks With Ixekizumab Plus Tirzepatide Versus Ixekizumab Alone in Adults With Psoriatic Arthritis and Obesity or Overweight: Additional Results From a Randomized Clinical Trial

Arthritis &Rheumatology, EarlyView.
Objective Obesity or overweight occurs in 72% to 82% of individuals with psoriatic arthritis (PsA). Previous data revealed greater disease control with concomitant ixekizumab (IXE) and tirzepatide (TZP) versus IXE alone in adults with active PsA and obesity or overweight with at least one weight‐related comorbidity at the week 36 primary end point. The
Joseph F. Merola, Cynthia E. Kartman, Peter Fischer, Philip Mease, Alan Kivitz, Naveed Sattar, Laura C. Coates, Daniel Aletaha, Luna Sun, Yurong Chen, Ketan Marulkar, Natalia Bello, Anabela Cardoso, Mark C. Genovese, Alexis Ogdie   +14 more
wiley   +1 more source

Correlation of triglyceride glucose-body mass index, triglyceride glucose/high-density lipoprotein cholesterol ratio, and triglyceride glucose index with blood sugar and hemoglobin A1C in patients with type 2 diabetes mellitus: A cross-sectional study

Asian Journal of Medical Sciences
Background: Type 2 diabetes mellitus (T2DM) is one of the most common endocrine diseases characterized by increased blood glucose. Uncontrolled diabetes is associated with the development of micro- and macrovascular complications. Aims and Objectives:
Srikanth Akula , Swetha Akkina , Gandham Rajeev , Preethi Batakala , Bhagyalakshmi Atla , Sunkara Uha Priya , Divija Reddy Bonthu   +6 more
doaj   +1 more source