Results 21 to 30 of about 415 (104)

APOE ε2 resilience for Alzheimer's disease is mediated by plasma lipid species: Analysis of three independent cohort studies

Alzheimer's &Dementia, Volume 18, Issue 11, Page 2151-2166, November 2022., 2022
Abstract Introduction The apolipoprotein E (APOE) genotype is the strongest genetic risk factor for late‐onset Alzheimer's disease. However, its effect on lipid metabolic pathways, and their mediating effect on disease risk, is poorly understood. Methods We performed lipidomic analysis on three independent cohorts (the Australian Imaging, Biomarkers ...
Tingting Wang, Kevin Huynh, Corey Giles, Natalie A Mellett, Thy Duong, Anh Nguyen, Wei Ling Florence Lim, Alex AT Smith, Gavriel Olshansky, Gemma Cadby, Joseph Hung, Jennie Hui, John Beilby, Gerald F Watts, Pratishtha Chatterjee, Ian Martins, Simon M Laws, Ashley I Bush, Christopher C Rowe, Victor L Villemagne, David Ames, Colin L Masters, Kevin Taddei, Vincent Doré, Jürgen Fripp, Matthias Arnold, Gabi Kastenmüller, Kwangsik Nho, Andrew J Saykin, Rebecca Baillie, Xianlin Han, Ralph N Martins, Eric K Moses, Rima Kaddurah‐Daouk, Peter J Meikle   +34 more
wiley   +1 more source

Correlation between metabolomic profile constituents and feline pancreatic lipase immunoreactivity

Journal of Veterinary Internal Medicine, Volume 36, Issue 2, Page 473-481, March 2022., 2022
Abstract Background Feline pancreatic lipase immunoreactivity (fPLI) is commonly used to diagnose pancreatitis in cats (FP). Untargeted metabolomics has been extensively applied in human and veterinary medicine, but no metabolomic studies regarding FP have been conducted.
Magdalena Maria Krasztel, Michał Czopowicz, Olga Szaluś‐Jordanow, Agata Moroz, Marcin Mickiewicz, Jarosław Kaba   +5 more
wiley   +1 more source

On phenotyping in asthma and COPD [PDF]

, 2013
Roken beïnvloedt de respons van astmapatiënten op medicijnen Geïnhaleerde corticosteroïden (ICS) zijn veelgebruikte medicijnen in de behandeling van astma en COPD, maar astmapatiënten reageren over het algemeen beter op de behandeling met deze medicijnen
Telenga, Evert Dirk
core   +10 more sources

Metabolite Characteristics in Tongue Coating from Damp Phlegm Pattern in Patients with Gastric Precancerous Lesion

Evidence-Based Complementary and Alternative Medicine, Volume 2021, Issue 1, 2021., 2021
Objective. In this study, we analyzed the metabolite profile of the tongue coating of patients having gastric precancerous lesion (GPL) with damp phlegm pattern and proposed a mechanism of pathological transition. Methods. The changes in tongue‐coating metabolites in patients with GPL damp phlegm pattern were analyzed using GC‐TOF‐MS and UHPLC‐QE‐MS ...
Yifeng Xu, Renling Zhang, Robert Morris, Feng Cheng, Yiqin Wang, Zhujing Zhu, Yiming Hao, Yu CAI   +7 more
wiley   +1 more source

Exploration of Multi-Aspect Development of Chronic Obstructive Pulmonary Disease Pathogenesis, Diagnosis, and Treatment Management [PDF]

, 2022
Chronic obstructive pulmonary disease (COPD) is a common, preventable, and treatable chronic respiratory disease, which is characterized by persistent airflow limitation and respiratory symptoms.
He, Xiang, Li, Guoping, Liu, Jiliu, Zhang, Lei, Zhang, Yi, Zuo, Xiaohui   +5 more
core   +2 more sources

Plasma lipidomic analysis of sphingolipids in patients with large artery atherosclerosis cerebrovascular disease and cerebral small vessel disease. [PDF]

Biosci Rep, 2020
Background: Sphingolipids mainly consist of ceramides (Cer), sphingomyelins (SM) and glycosphingolipids. Sphingolipids are related with coronary heart disease and metabolic disease, but there’re few studies about cerebrovascular disease.
You Q, Peng Q, Yu Z, Jin H, Zhang J, Sun W, Huang Y.   +6 more
europepmc   +2 more sources

Concordant peripheral lipidome signatures in two large clinical studies of Alzheimer’s disease [PDF]

, 2020
© 2020, The Author(s). Changes to lipid metabolism are tightly associated with the onset and pathology of Alzheimer’s disease (AD). Lipids are complex molecules comprising many isomeric and isobaric species, necessitating detailed analysis to enable ...
Ames, David, Arnold, Matthias, Baillie, Rebecca, Bush, Ashley I., Chatterjee, Pratishtha, Drew, Brian G., Giles, Corey, Han, Xianlin, Huynh, Kevin, Jayawardana, Kaushala S., Kaddurah-Daouk, Rima, Laws, Simon M., Lim, Wei Ling Florence, Martins, Ian, Martins, Ralph N., Masters, Colin L., Meikle, Peter J., Mellett, Natalie A., Nho, Kwangsik, Olshansky, Gavriel, Rowe, Christopher C., Salim, Agus, Saykin, Andrew J., Smith, Adam Alexander T., Villemagne, Victor L.   +24 more
core   +2 more sources

Lipidome characterisation and sex-specific differences in type 1 and type 2 diabetes mellitus [PDF]

Background: In this study, we evaluated the lipidome alterations caused by type 1 diabetes (T1D) and type 2 diabetes (T2D), by determining lipids significantly associated with diabetes overall and in both sexes, and lipids associated with the glycaemic ...
Alonso Pedrol, Núria, Barranco-Altirriba, Maria, Capellades, Jordi, Castelblanco, Esmeralda, Dunn, Warwick B., Falguera, Mireia, Franch-Nadal, Josep, Hernandez, Marta, Jankevics, Andris, Lloyd, Gavin R., Mauricio Puente, Dídac, Perera Lluna, Alexandre, Universitat Autònoma de Barcelona, Weber, Ralf J.M., Winder, Catherine, Yanes, Oscar   +15 more
core   +6 more sources

Role of Sphingolipids in the Pathobiology of Lung Inflammation

Mediators of Inflammation, Volume 2015, Issue 1, 2015., 2015
Sphingolipid bioactivities in the respiratory airways and the roles of the proteins that handle them have been extensively investigated. Gas or inhaled particles or microorganisms come into contact with mucus components, epithelial cells, blood barrier, and immune surveillance within the airways.
Riccardo Ghidoni, Anna Caretti, Paola Signorelli, Ashley Snider   +3 more
wiley   +1 more source

Similar Alterations of the Stratum Corneum Ceramide Profile in Atopic Dermatitis, Psoriasis, and Ichthyosis::Results from a Systematic Review and Meta-Analysis [PDF]

Drug Delivery ...
Bouwstra, Joke A., Mergen, Catherine, Niemeyer-van der Kolk, Tessa, Rissmann, Robert, Rousel, Jannik, Schoones, Jan W., van Doorn, Martijn B.A., van Smeden, Jeroen   +7 more
core   +3 more sources