Results 11 to 20 of about 39,322 (281)
Identification of RING E3 pseudoligases in the TRIM protein family [PDF]
Nature CommunicationsTRIpartite Motif (TRIM) family proteins have diverse roles across a broad variety of cellular functions, which are largely presumed to depend on their ubiquitin E3 ligase activity, conferred by a RING domain.
Jane Dudley-Fraser +5 more
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The critical role of TRIM protein family in intervertebral disc degeneration: mechanistic insights and therapeutic perspectives [PDF]
Frontiers in Cell and Developmental BiologyIntervertebral disc degeneration (IVDD) is a leading cause of chronic back pain, contributing significantly to reduced quality of life and global public health burdens.
Shangze Li +4 more
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Structural analysis of TRIM family PRYSPRY domains and its implications for E3-ligand design [PDF]
Journal of Structural Biology: XTripartite motif (TRIM) proteins constitute one of the largest subfamilies of RING-type E3 ubiquitin ligases and are attractive targets for the development of novel degraders that exploit the ubiquitin–proteasome pathway.
Rezart Zhubi +4 more
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Emerging Roles of TRIM Family Proteins in Gliomas Pathogenesis. [PDF]
Cancers (Basel), 2022 Gliomas encompass a vast category of CNS tumors affecting both adults and children. Treatment and diagnosis are often impeded due to intratumor heterogeneity and the aggressive nature of the more malignant forms. It is therefore essential to elucidate the molecular mechanisms and explore the intracellular signaling pathways underlying tumor pathology ...
Giannopoulou AI +3 more
europepmc +6 more sources
PLoS Pathogens, 2014 PML nuclear bodies (PML-NBs) are enigmatic structures of the cell nucleus that act as key mediators of intrinsic immunity against viral pathogens. PML itself is a member of the E3-ligase TRIM family of proteins that regulates a variety of innate immune ...
Myriam Scherer +10 more
doaj +5 more sources
Beyond Tumors: The Pivotal Role of TRIM Proteins in Chronic Non-Tumor Lung Diseases [PDF]
Journal of Inflammation ResearchXiangfei Huang, Wen Yu, Aiping Wei, Xifeng Wang, Shibiao Chen Department of Anesthesiology, The First Affiliated Hospital of Nanchang University, Nanchang, 330006, People’s Republic of ChinaCorrespondence: Shibiao Chen, Department of Anesthesiology, The ...
Huang X, Yu W, Wei A, Wang X, Chen S
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The Function of TRIM25 in Antiviral Defense and Viral Immune Evasion [PDF]
VirusesTripartite motif (TRIM) 25 is a member of the TRIM E3 ubiquitin ligase family, which plays multiple roles in anti-tumor and antiviral defenses through various pathways.
Qianxun Liu +3 more
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The role of TRIM family proteins in the regulation of cancer stem cell self-renewal. [PDF]
Stem Cells, 2020 AbstractThe tripartite-motif (TRIM) family of proteins represents one of the largest classes of putative single protein RING-finger E3 ubiquitin ligases. The members of this family are characterized by an N-terminal TRIM motif containing one RING-finger domain, one or two zinc-finger domains called B boxes (B1 box and B2 box), and a coiled-coil region.
Jaworska AM +3 more
europepmc +4 more sources
The Roles of TRIMs in Antiviral Innate Immune Signaling
Frontiers in Cellular and Infection Microbiology, 2021 The Tripartite motif (TRIM) protein family, which contains over 80 members in human sapiens, is the largest subfamily of the RING-type E3 ubiquitin ligase family.
Zhou Shen +8 more
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Cells, 2021 The tripartite motif (TRIM) protein family is attracting increasing interest in oncology. As a protein family based on structure rather than function, a plethora of biological activities are described for TRIM proteins, which are implicated in multiple ...
Eleonora Pauletto +4 more
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