Results 11 to 20 of about 18,998 (226)

Emerging Roles of TRIM Family Proteins in Gliomas Pathogenesis [PDF]

Cancers, 2022
Gliomas encompass a vast category of CNS tumors affecting both adults and children. Treatment and diagnosis are often impeded due to intratumor heterogeneity and the aggressive nature of the more malignant forms. It is therefore essential to elucidate the molecular mechanisms and explore the intracellular signaling pathways underlying tumor pathology ...
Christina Piperi, Efterpi Kostareli, Piperi Christina   +2 more
exaly   +6 more sources

TRIM family proteins and their emerging roles in innate immunity [PDF]

Nature Reviews Immunology, 2008
The superfamily of tripartite motif-containing (TRIM) proteins is conserved throughout the metazoan kingdom and has expanded rapidly during vertebrate evolution; there are now more than 60 TRIM proteins known in humans and mice. Many TRIM proteins are induced by type I and type II interferons, which are crucial for many aspects of resistance to ...
Anup Dey, Dong-Mi Shin, Herbert Morse
exaly   +5 more sources

Emerging Role and Potential Therapeutic Application of TRIM Proteins in Cardiovascular Diseases [PDF]

Biomolecules
Cardiovascular diseases have high mortality rates and present a high burden on society and the global healthcare system. A large quantity of drugs have been developed, such as aspirin, ACE inhibitors, beta-blockers, and statins.
Yiyang Cui, Yuxuan Wen, Xinling Wang, Yu Xu, Meixiu Jiang   +4 more
doaj   +2 more sources

Updates on the role of TRIM proteins in AIDS: molecular mechanisms and potential for interventions [PDF]

Frontiers in Immunology
AIDS (acquired immunodeficiency syndrome) is the final stage of infection with the human immunodeficiency virus (HIV) and adversely impacts the health of affected people globally, placing an added burden on healthcare systems.
Jingxian Chen, Siyu Chen, Yu Xu, Xinling Wang, Meixiu Jiang   +4 more
doaj   +2 more sources

Identification of RING E3 pseudoligases in the TRIM protein family

Nature Communications
TRIpartite Motif (TRIM) family proteins have diverse roles across a broad variety of cellular functions, which are largely presumed to depend on their ubiquitin E3 ligase activity, conferred by a RING domain.
Jane Dudley-Fraser, Diego Esposito, Katherine A. McPhie, Coltrane Morley-Williams, Tania Auchynnikava, Katrin Rittinger   +5 more
doaj   +3 more sources

Structural analysis of TRIM family PRYSPRY domains and its implications for E3-ligand design [PDF]

Journal of Structural Biology: X
Tripartite motif (TRIM) proteins constitute one of the largest subfamilies of RING-type E3 ubiquitin ligases and are attractive targets for the development of novel degraders that exploit the ubiquitin–proteasome pathway.
Rezart Zhubi, Apirat Chaikuad, Christian J. Muñoz Sosa, Andreas C. Joerger, Stefan Knapp   +4 more
doaj   +2 more sources

The critical role of TRIM protein family in intervertebral disc degeneration: mechanistic insights and therapeutic perspectives

Frontiers in Cell and Developmental Biology
Intervertebral disc degeneration (IVDD) is a leading cause of chronic back pain, contributing significantly to reduced quality of life and global public health burdens.
Shangze Li, Wenli Jiang, Fei Chen, Jiao Qian, Jun Yang   +4 more
doaj   +3 more sources

The role of TRIM family proteins in the regulation of cancer stem cell self-renewal. [PDF]

Stem Cells, 2020
AbstractThe tripartite-motif (TRIM) family of proteins represents one of the largest classes of putative single protein RING-finger E3 ubiquitin ligases. The members of this family are characterized by an N-terminal TRIM motif containing one RING-finger domain, one or two zinc-finger domains called B boxes (B1 box and B2 box), and a coiled-coil region.
Jaworska AM, Wlodarczyk NA, Mackiewicz A, Czerwinska P.   +3 more
europepmc   +4 more sources

Roles and Mechanisms of TRIM Family Proteins in Inflammation in the Brain and Beyond. [PDF]

Int J Mol Sci
Neurodegeneration is closely linked to neuroinflammation and is frequently accompanied by comorbidities with inflammatory features. Tripartite motif (TRIM) proteins are known to play an important role in innate immunity and inflammatory signaling in various tissues and organs of the body, including the central nervous system.
Gerasimova T, Kotok A, Saltykova S, Stepanenko E, Eremeev A, Novosadova E, Tarantul V, Nenasheva V.   +7 more
europepmc   +4 more sources

The Roles of TRIMs in Antiviral Innate Immune Signaling

Frontiers in Cellular and Infection Microbiology, 2021
The Tripartite motif (TRIM) protein family, which contains over 80 members in human sapiens, is the largest subfamily of the RING-type E3 ubiquitin ligase family.
Zhou Shen, Zhou Shen, Lin Wei, Zhi-bo Yu, Zhi-yan Yao, Jing Cheng, Yu-tong Wang, Xiao-tian Song, Miao Li   +8 more
doaj   +1 more source