Results 231 to 240 of about 39,322 (281)

Dynamic Shifts in ER–Plasma Membrane Junctions Signaling Define Pro‐Metastatic N‐Glycosylation and Predict Prostate Cancer Progression

Advanced Science, EarlyView.
Prostate cancer remains a leading cause of male cancer death, yet screening cannot reliably identify aggressive disease, underscoring the need for tissue biomarkers. It is shown that primary tumors increase ER–plasma membrane junction signaling via STIM1/ORP5, whereas metastasis features their loss, Golgi dispersal, and rapid conversion of high‐mannose
Amanda J. Macke, Tania Kamal, Taylor E. Divita, Artem N. Pachikov, Chad A. LaGrange, Rajesh Ravichandran, Martha Morton, Robert Powers, Haowen Qiu, Jean‐Jack M. Riethoven, Colm Morrissey, Melinda Wojtkiewicz, Rebekah L. Gundry, Carol A. Casey, Armen Petrosyan   +14 more
wiley   +1 more source

TRIM24 promotes proliferation and metastasis of gastric cancer via mediating NRBP1 ubiquitination. [PDF]

Cell Death Dis
Weng C, Xu J, He C, Jin R, Jin X, Sun S, Pan S, Li M, Hu Y, Wang X, Zhang Y, Hu C, Xu Z, Lv B.   +13 more
europepmc   +1 more source

A Murine Database of Structural Variants Identifies A Candidate Gene for a Spontaneous Murine Lymphoma Model

Advanced Science, EarlyView.
We analyzed long‐read genomic sequencing data obtained from 40 inbred mouse strains to produce a large database of structural variants. This dataset captures the major types of structural variants, which includes deletions, insertions, duplications, and inversions.
Wenlong Ren, Zhuoqing Fang, Egor Dolzhenko, Christopher T. Saunders, Zhuanfen Cheng, Victoria Popic, Gary Peltz   +6 more
wiley   +1 more source

Loss of TRIM44 promotes renal cell carcinoma progression by regulating K48-linked ubiquitination of vimentin. [PDF]

J Biol Chem
Shi K, Jia B, Li Y, Feng X, Sun X, Liu Q, Zhang W, Tian Y, Miao X, Liu Y, Zhao H, Kang L, Zhao T, Zhang S, Liu J, Liu S.   +15 more
europepmc   +1 more source

Multi‐Tissue Omics Analysis Uncovers Translational Regulation Underlying Complex Traits in Pigs

Advanced Science, EarlyView.
Integrated multi‐omics across pig breeds and tissues reveals key principles of post‐transcriptional translational regulation and their contribution to trait formation. A gene network framework integrating transcriptomic and translatomic data is developed and applied to elucidate the genetic basis of meat production, offering new insights into mammalian
Chao Wang, Yuanyuan Zhang, Choulin Chen, Xiaoxian Xu, Shenghua Qin, Junyan Qi, Yongzhou Bao, Huiming Li, Ruipu Chen, Weigang Zheng, Zhilong Chen, Lingzhao Fang, Yunxiang Zhao, Yuwen Liu   +13 more
wiley   +1 more source

Guidelines for the Anti‐Obesity Assays of Food Bioactives in Caenorhabditis elegans

AgriFood: Journal of Agricultural Products for Food, EarlyView.
This Guideline uses Caenorhabditis elegans as a model organism to systematically explain and summarize the research strategies and experimental methods for the anti‐obesity effects of food bioactives. ABSTRACT The obesity has become a global public health problem and is closely related to a variety of chronic diseases.
Rui Lu
wiley   +1 more source

TRIM6 Promotes Cell Cycle and Growth by Modulating p53 Signaling Pathway in Lung Adenocarcinoma. [PDF]

Int J Gen Med
Lu X, Wang H, Yu T.
europepmc   +1 more source

A No-Brainer! The Therapeutic Potential of TRIM Proteins in Viral and Central Nervous System Diseases. [PDF]

Viruses
Hage A, Janes M, Best SM.
europepmc   +1 more source

Translational repression by 4E-T is crucial to maintain the prophase-I arrest in vertebrate oocytes. [PDF]

Nat Commun
Heim A, Cheng S, Orth J, Stengel F, Schuh M, Mayer TU.   +5 more
europepmc   +1 more source

Grass carp Trim47 restricts GCRV infection via SPRY domain-mediated autophagic degradation of nonstructural proteins and disruption of viral inclusion bodies. [PDF]

Front Immunol
Yan W, Chen Y, Yan D, Zhang J, Chang MX.
europepmc   +1 more source