Results 41 to 50 of about 39,322 (281)
PLoS ONE, 2011 Tripartite motif proteins (TRIM) constitute a large family of proteins containing a RING-Bbox-Coiled Coil motif followed by different C-terminal domains. Involved in ubiquitination, TRIM proteins participate in many cellular processes including antiviral
Pierre Boudinot +7 more
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The Echinococcus canadensis (G7) genome: A key knowledge of parasitic platyhelminth human diseases [PDF]
, 2017 Background: The parasite Echinococcus canadensis (G7) (phylum Platyhelminthes, class Cestoda) is one of the causative agents of echinococcosis. Echinococcosis is a worldwide chronic zoonosis affecting humans as well as domestic and wild mammals, which ...
A Bankevich +109 more
core +8 more sources
TRIM16 acts as an E3 ubiquitin ligase and can heterodimerize with other TRIM family members.
PLoS ONE, 2012 The TRIM family of proteins is distinguished by its tripartite motif (TRIM). Typically, TRIM proteins contain a RING finger domain, one or two B-box domains, a coiled-coil domain and the more variable C-terminal domains.
Jessica L Bell +7 more
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TRIM29 in Cutaneous Squamous Cell Carcinoma
Frontiers in Medicine, 2021 Tripartite motif (TRIM) proteins play important roles in a wide range of cell physiological processes, such as signal transduction, transcriptional regulation, innate immunity, and programmed cell death.
Che-Yuan Hsu +2 more
doaj +1 more source
The melanoma-associated antigen 1 (MAGEA1) protein stimulates the E3 ubiquitin-ligase activity of TRIM31 within a TRIM31-MAGEA1-NSE4 complex [PDF]
, 2015 The MAGE (Melanoma-associated antigen) protein family members are structurally related to each other by a MAGEhomology domain comprised of 2 winged helix motifs WH/A and WH/B. This family specifically evolved in placental mammals although single homologs
Alan R Lehmann +11 more
core +3 more sources
Expression profiling of TRIM protein family in THP1-derived macrophages following TLR stimulation [PDF]
Scientific Reports, 2017 AbstractActivated macrophages play an important role in many inflammatory diseases including septic shock and atherosclerosis. However, the molecular mechanisms limiting macrophage activation are not completely understood. Members of the tripartite motif (TRIM) family have recently emerged as important players in innate immunity and antivirus. Here, we
Mei-Xiu Jiang +11 more
openaire +2 more sources
TRIM E3 ligases interfere with early and late stages of the retroviral life cycle.
PLoS Pathogens, 2008 Members of the TRIpartite interaction Motif (TRIM) family of E3 ligases have been shown to exhibit antiviral activities. Here we report a near comprehensive screen for antiretroviral activities of 55 TRIM proteins (36 human, 19 mouse).
Pradeep D Uchil +4 more
doaj +1 more source
Frontiers in Molecular Neuroscience, 2023 The tripartite motif (TRIM) protein family members have been implicated in a multitude of physiologies and pathologies in different tissues. With diverse functions in cellular processes including regulation of signaling pathways, protein degradation, and
Jane Dudley-Fraser, Katrin Rittinger
doaj +1 more source
Molecular mechanism of influenza A NS1-mediated TRIM25 recognition and inhibition [PDF]
, 2018 RIG-I is a viral RNA sensor that induces the production of type I interferon (IFN) in response to infection with a variety of viruses. Modification of RIG-I with K63-linked poly-ubiquitin chains, synthesised by TRIM25, is crucial for activation of the ...
Cusack, S +10 more
core +2 more sources
Identification and characterization of multiple TRIM proteins that inhibit hepatitis B virus transcription. [PDF]
PLoS ONE, 2013 Tripartite motif (TRIM) proteins constitute a family of over 100 members that share conserved tripartite motifs and exhibit diverse biological functions. Several TRIM proteins have been shown to restrict viral infections and regulate host cellular innate
Shijian Zhang +3 more
doaj +1 more source