Results 71 to 80 of about 39,322 (281)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

TRIM56 promotes malignant progression of glioblastoma by stabilizing cIAP1 protein

Journal of Experimental & Clinical Cancer Research, 2022
Background The tripartite motif (TRIM) family of proteins plays a key role in the developmental growth and therapeutic resistance of many tumors. However, the regulatory mechanisms and biological functions of TRIM proteins in human glioblastoma (GBM) are
Xu Yang, Yan Zhang, Zhiwei Xue, Yaotian Hu, Wenjing Zhou, Zhiyi Xue, Xuemeng Liu, Guowei Liu, Wenjie Li, Xiaofei Liu, Xingang Li, Mingzhi Han, Jian Wang   +12 more
doaj   +1 more source

Identification of a Shrimp E3 Ubiquitin Ligase TRIM50-Like Involved in Restricting White Spot Syndrome Virus Proliferation by Its Mediated Autophagy and Ubiquitination

Frontiers in Immunology, 2021
Most tripartite motif (TRIM) family proteins are critical components of the autophagy machinery and play important roles in host defense against viral pathogens in mammals.
Chao Zhao, Chao Zhao, Chao Peng, Pengfei Wang, Pengfei Wang, Lulu Yan, Lulu Yan, Sigang Fan, Sigang Fan, Lihua Qiu, Lihua Qiu, Lihua Qiu   +11 more
doaj   +1 more source

The Discrete Nonlinear Schr\"odinger equation - 20 Years on

, 2002
We review work on the Discrete Nonlinear Schr\"odinger (DNLS) equation over the last two decades.Comment: 24 pages, 1 figure, Proceedings of the conference on "Localization and Energy Transfer in Nonlinear Systems", June 17-21, 2002, San Lorenzo de ...
Eilbeck, J. Chris, Johansson, Magnus
core   +3 more sources

Fish species-specific TRIM gene FTRCA1 negatively regulates interferon response through attenuating IRF7 transcription [PDF]

, 2019
In mammals and fish, emerging evidence highlights that TRIM family members play important roles in the interferon (IFN) antiviral immune response. Fish TRIM family has undergone an unprecedented expansion leading to generation of finTRIM subfamily, which
Dan, Cheng, Gui, Jian-Fang, Wu, Min, Zhang, Yi-Bing   +3 more
core   +1 more source

The Adenovirus E4 ORF3 Protein Binds and Reorganizes the TRIM Family Member Transcriptional Intermediary Factor 1 Alpha [PDF]

Journal of Virology, 2007
ABSTRACT One of the most interesting functions attributed to the adenovirus early region 4 open reading frame 3 (E4 ORF3) protein is its reorganization of promyelocytic leukemia (PML) protein nuclear bodies. These normally punctate structures are reorganized by E4 ORF3 into tracks that eventually surround viral replication centers.
Mark A, Yondola, Patrick, Hearing
openaire   +2 more sources

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

TRIM proteins as emerging regulators of immune pathways: potential therapeutic targets in immune-related disorders

Frontiers in Immunology
Tripartite motif (TRIM) proteins constitute a versatile family of E3 ubiquitin ligases that regulate key signaling pathways governing innate and adaptive immune responses.
Bilal Jawed, Bilal Jawed, Rimsha Kanwal, Rimsha Kanwal, Syed Khuram Zakir, Syed Khuram Zakir, Francesco Gaudio, Francesco Gaudio, Jessica Elisabetta Esposito, Azfar Athar Ishaqui, Stefano Martinotti, Stefano Martinotti, Matteo Botteghi, Elena Toniato   +13 more
doaj   +1 more source

The genomes of two key bumblebee species with primitive eusocial organization [PDF]

, 2015
Background: The shift from solitary to social behavior is one of the major evolutionary transitions. Primitively eusocial bumblebees are uniquely placed to illuminate the evolution of highly eusocial insect societies.
Amdam, Gro V., Antonio, David S. Marco, Aqrawi, Peshtewani K., Asher, Claire, Barribeau, Seth M., Beckers, Matthew, Bennett, Anna K., Beye, Martin, Biewer, Matthias, Bitondi, Márcia M. G., Blankenburg, Kerstin P., Blaxter, Mark L., Bloch, Guy, Blommaert, Julie, Bornberg-Bauer, Erich, Bourke, Andrew F. G., Brown, Mark J. F., Buechel, Severine D., Cameron, Rossanah, Cappelle, Kaat, Carolan, James C., Chipman, Ariel D., Chittka, Lars, Christiaens, Olivier, Ciborowski, Kate L., Clarke, David F., Colgan, Thomas J., Collins, David H., Coyle, Marcus, Cridge, Andrew G., Câmara, Francisco, Dalmay, Tamas, de Graaf, Dirk C., Dearden, Peter, Debyser, Griet, Devreese, Bart, Dreier, Stephanie, du Plessis, Louis, Duncan, Elizabeth, Elsik, Christine G., Erler, Silvio, Evans, Jay, Falcon, Tiago, Flores, Kevin, Fouks, Bertrand, Francisco, Liezl, Freitas, Flávia C. P., Fuchikawa, Taro, Gadau, Jürgen, Gempe, Tanja, Gibbs, Richard A., Grimmelikhuijzen, Cornelis J. P., Guigó, Roderic, Hartfelder, Klaus, Hasselmann, Martin, Hauser, Frank, Helbing, Sophie, Hernandez, Alvaro G., Hoff, Katharina, Holder, Michael, Hudson, Matthew E., Humann, Fernanda C., Irvine, Frano, Jackson, Laronda, Jayaseelan, Joy, Jermiin, Lars S., Johnson, Claire E., Johnson, Reed M., Jones, Andrew K., Joshi, Vandita, Kadowaki, Tatsuhiko, Kidner, Jonathan H., Klasberg, Steffen, Koch, Vasco, Kovar, Christie, Kraus, F Bernhard, Köhler, Arian, Lattorff, H. Michael G., Leask, Megan, Lee, Sandra L., Liu, Jisheng, Lockett, Gabrielle A., Lozier, Jeffrey D., Mallon, Eamonn B., Mariotti, Marco, Marxer, Monika, Mata, Robert, Mathew, Tittu, Meeus, Ivan, Moritz, Robin F. A., Munoz-Torres, Monica, Murphy, Terence, Muzny, Donna M., Nair, Ajay, Newsham, Irene F., Ngo, Robin, Nissen, Inga, Niu, Jinzhi, Nunes, Francis M. F., Näpflin, Kathrin, O'Neill, Meaghan P., Oakeshott, John G., Okwuonu, Geoffrey, Osborne, Amy, Otte, Marianne, Pham, Christopher, Pinheiro, Daniel G., Pu, Ling-Ling, Puiu, Daniela, Qu, Jiaxin, Richards, Stephen, Robertson, Hugh M., Robinson, Gene E., Rossié, Nina, Rueppell, Olav, Saada, Nehad, Sadd, Ben M., Salzberg, Steven L., Santesmasses, Didac, Santibanez, Jireh, Santos, Carolina G., Scherer, Steven E., Schmid-Hempel, Paul, Schmid-Hempel, Regula, Schmitt, Björn D., Schulte, Christina, Simmons, Denard, Simões, Zilá Lp, Smagghe, Guy, Soares, Michelle P. M., Stolle, Eckart, Sumner, Seirian, Swevers, Luc, Thornton, Rebecca, van Vaerenbergh, Matthias, Venkat, Aarti, Walden, Kimberly K. O., Waterhouse, Robert M., Winnebeck, Eva C., Wolschin, Florian, Worley, Kim C., Wu, Yuan-Qing, Yu, Na, Zdobnov, Evgeny M.   +143 more
core   +16 more sources

The E3-Ligase TRIM Family of Proteins Regulates Signaling Pathways Triggered by Innate Immune Pattern-Recognition Receptors [PDF]

Immunity, 2013
Innate immunity conferred by the type I interferon is critical for antiviral defense. To date only a limited number of tripartite motif (TRIM) proteins have been implicated in modulation of innate immunity and anti-microbial activity. Here we report the complementary DNA cloning and systematic analysis of all known 75 human TRIMs.
Versteeg, Gijs A., Rajsbaum, Ricardo, Sánchez-Aparicio, Maria Teresa, Maestre, Ana M., Valdiviezo, Julio, Shi, Mude, Inn, Kyung-Soo, Fernandez-Sesma, Ana, Jung, Jae, García-Sastre, Adolfo   +9 more
openaire   +2 more sources