Results 11 to 20 of about 5,785,343 (209)
TRIM proteins in neuroblastoma. [PDF]
Biosci Rep, 2019 Neuroblastoma (NB) is the most common extracranial solid tumor in childhood. Outcome for children with high-risk NB remains unsatisfactory. Accumulating evidence suggests that tripartite motif (TRIM) family proteins express diversely in various human ...
Xu Y, Zhang Z, Xu G.
europepmc +5 more sources
TRIM proteins in blood cancers. [PDF]
J Cell Commun Signal, 2018 Post-translational modification of proteins with ubiquitin plays a central role in regulating numerous cellular processes. E3 ligases determine the specificity of ubiquitination by mediating the transfer of ubiquitin to substrate proteins.
Crawford LJ, Johnston CK, Irvine AE.
europepmc +8 more sources
TRIM Proteins in Host Defense and Viral Pathogenesis. [PDF]
Curr Clin Microbiol Rep, 2020 Tripartite motif (TRIM) proteins are a large group of E3 ubiquitin ligases involved in different cellular functions. Of special interest are their roles in innate immunity, inflammation, and virus replication.
Giraldo MI +3 more
europepmc +5 more sources
Multifaceted Roles of TRIM Proteins in Colorectal Carcinoma. [PDF]
Int J Mol Sci, 2020 Colorectal cancer (CRC) is one of the most frequently diagnosed tumor in humans and one of the most common causes of cancer-related death worldwide. The pathogenesis of CRC follows a multistage process which together with somatic gene mutations is mainly
Eberhardt W +3 more
europepmc +7 more sources
Targeting TRIM Proteins: A Quest towards Drugging an Emerging Protein Class. [PDF]
Chembiochem, 2021 The ubiquitylation machinery regulates several fundamental biological processes from protein homeostasis to a wide variety of cellular signaling pathways.
D'Amico F +3 more
europepmc +7 more sources
TRIM proteins legitimately enter the MAGEic RING. [PDF]
Cell Cycle, 2015 Comment on 'The melanoma-associated antigen 1 (MAGEA1) protein stimulates the E3 ubiquitin-ligase activity of TRIM31 within a TRIM31-MAGEA1-NSE4 complex' [Cell Cycle ...
Zanchetta ME, Meroni G.
europepmc +7 more sources
The antiviral activities of TRIM proteins. [PDF]
Curr Opin Microbiol, 2021 Tripartite motif (TRIM) proteins are a highly versatile family of host-cell factors that play an integral role in the mammalian defense against pathogens. TRIM proteins regulate either transcription-dependent antiviral responses such as pro-inflammatory cytokine induction, or they modulate other important cell-intrinsic defense pathways like autophagy.
Koepke L, Gack MU, Sparrer KM.
europepmc +5 more sources
E3 Ubiquitin Ligase TRIM Proteins, Cell Cycle and Mitosis. [PDF]
Cells, 2019 The cell cycle is a series of events by which cellular components are accurately segregated into daughter cells, principally controlled by the oscillating activities of cyclin-dependent kinases (CDKs) and their co-activators.
Venuto S, Merla G.
europepmc +8 more sources
CSNK2 suppresses autophagy by activating FLN-NHL-containing TRIM proteins. [PDF]
Autophagy, 2023 Macroautophagy/autophagy is a tightly regulated cellular process integral to homeostasis and innate immunity. As such, dysregulation of autophagy is associated with cancer, neurodegenerative disorders, and infectious diseases. While numerous factors that
Hoenigsperger H +9 more
europepmc +2 more sources
TRIM Proteins in Colorectal Cancer: TRIM8 as a Promising Therapeutic Target in Chemo Resistance. [PDF]
Biomedicines, 2021 Colorectal cancer (CRC) represents one of the most widespread forms of cancer in the population and, as all malignant tumors, often develops resistance to chemotherapies with consequent tumor growth and spreading leading to the patient’s premature death.
Marzano F +4 more
europepmc +2 more sources