Results 31 to 40 of about 5,785,343 (209)
Unveiling the multifaceted functions of TRIM proteins in glioma pathogenesis [PDF]
Translational OncologyGliomas, the most prevalent malignant primary brain tumors in adults, represent a heterogeneous group of neoplasms characterized by poor prognosis and limited therapeutic options, particularly in high-grade cases.
Wenjie Wu +3 more
doaj +2 more sources
Structural basis for the recognition and degradation of host TRIM proteins by Salmonella effector SopA. [PDF]
Nat Commun, 2017 The hallmark of Salmonella Typhimurium infection is an acute intestinal inflammatory response, which is mediated through the action of secreted bacterial effector proteins. The pro-inflammatory Salmonella effector SopA is a HECT-like E3 ligase, which was
Fiskin E +5 more
europepmc +2 more sources
Novel TRIM Proteins Modulating the Innate Immune Response of Rainbow Trout (Oncorhynchus mykiss) [PDF]
AnimalsIn higher vertebrates, Tripartite Motif (TRIM) proteins modulate the immune response by coordinating processes related to inflammation such as antiviral restriction, autophagy and inflammasome activation.
Francisco Donoso +9 more
doaj +2 more sources
TRIM proteins in autophagy: selective sensors in cell damage and innate immune responses. [PDF]
Cell Death Differ, 2020 Di Rienzo M +4 more
europepmc +2 more sources
PLoS ONE, 2011 Tripartite motif proteins (TRIM) constitute a large family of proteins containing a RING-Bbox-Coiled Coil motif followed by different C-terminal domains. Involved in ubiquitination, TRIM proteins participate in many cellular processes including antiviral
Pierre Boudinot +7 more
doaj +7 more sources
Biomedicine & Pharmacotherapy, 2021 Fibrosis is an outcome of tissue repair after different types of injuries. The homeostasis of extracellular matrix is broken, and excessive deposition occurs, affecting the normal function of tissues and organs, which could become prostrated in serious cases.Finding a suitable target to regulate the repair process and reduce the damage caused by ...
Hao Qian, Lijuan Chen
semanticscholar +3 more sources
TRIM proteins and diseases. [PDF]
Journal of Biochemistry, 2017 Ubiquitination is one of the posttranslational modifications that regulates a number of intracellular events including signal transduction, protein quality control, transcription, cell cycle, apoptosis and development. The ubiquitin system functions as a garbage machine to degrade target proteins and as a regulator for several signalling pathways ...
Masashi Watanabe, S. Hatakeyama
semanticscholar +3 more sources
The Roles of TRIMs in Antiviral Innate Immune Signaling
Frontiers in Cellular and Infection Microbiology, 2021 The Tripartite motif (TRIM) protein family, which contains over 80 members in human sapiens, is the largest subfamily of the RING-type E3 ubiquitin ligase family.
Zhou Shen +8 more
doaj +1 more source
Journal of Advanced Research, 2023 Background: Tripartite motif (TRIM) family proteins have more than 80 members and are widely found in various eukaryotic cells. Most TRIM family proteins participate in the ubiquitin-proteasome degradation system as E3-ubiquitin ligases; therefore, they ...
Junjie Gu +4 more
doaj +1 more source
Human TRIM gene expression in response to interferons. [PDF]
PLoS ONE, 2009 BackgroundTripartite motif (TRIM) proteins constitute a family of proteins that share a conserved tripartite architecture. The recent discovery of the anti-HIV activity of TRIM5alpha in primate cells has stimulated much interest in the potential role of ...
Laetitia Carthagena +10 more
doaj +1 more source