Effect of trimetazidine on left ventricular functions and cardiac biomarkers in diabetic patients with left ventricular diastolic dysfunction: a randomized controlled trial [PDF]
Scientific ReportsWe investigated the impact of trimetazidine treatment on left ventricular (LV) functions and cardiac biomarkers in diabetic patients with diastolic dysfunction as an early stage of diabetic cardiomyopathy.
Heba Serag +5 more
doaj +3 more sources
Effects of trimetazidine on heart failure with reduced ejection fraction and associated clinical outcomes: a systematic review and meta-analysis [PDF]
Open HeartBackground Despite maximal treatment, heart failure (HF) remains a major clinical challenge. Besides neurohormonal overactivation, myocardial energy homoeostasis is also impaired in HF.
M Louis Handoko +5 more
doaj +3 more sources
[Retracted] Observation of Curative Effect of Trimetazidine Combined with Metoprolol in Elderly Patients with Coronary Heart Disease Complicated with Heart Failure and the Effect of Myocardial Remodeling by Integrated Traditional Chinese and Western Medicine [PDF]
BioMed Research International, 2022 Diabetic retinopathy (DR) is the most common complication of diabetes and is often characterized by damage to retinal vascular microcirculation, resulting in retinal exudation, hemorrhage, fibrosis, and neovascularization.
Yingyi Lu +4 more
openalex +2 more sources
Neuropsychiatric Disease and Treatment, 2018 Meiyan Liu,1,* Wanlin Wei,2,* Christopher R Stone,3 Lijun Zhang,1 Guoxiang Tian,4 Jessie N Ding3 1Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, People’s Republic of China; 2Department of Cardiology, PLA ...
Liu MY +5 more
doaj +3 more sources
Trimetazidine Attenuates Heart Failure by Improving Myocardial Metabolism via AMPK
Frontiers in Pharmacology, 2021 Energic deficiency of cardiomyocytes is a dominant cause of heart failure. An antianginal agent, trimetazidine improves the myocardial energetic supply.
Hongyang Shu +13 more
doaj +2 more sources
Effects of trimetazidine on oxidant-antioxidant balance and angiogenesis; an in vivo experimental study [PDF]
BMC Cardiovascular DisordersBackground We evaluated the effects of trimetazidine (TMZ) on the oxidative-antioxidative balance and angiogenesis in an in vivo experimental model. This study aims to evaluate the effects of trimetazidine on angiogenesis through histological analysis ...
Fethullah Kayan, Hasan Basri Savas
doaj +2 more sources
The imPAct of Trimetazidine on MicrOcirculation after Stenting for stable coronary artery disease (PATMOS study) [PDF]
Frontiers in Cardiovascular Medicine, 2023 Background Myocardial ischemia is caused by epicardial coronary artery stenosis or atherosclerotic disease affecting microcirculation. Trimetazidine (TMZ), promotes glucose oxidation which optimizes cellular energy processes in ischemic conditions. Small
Ivan Ilić +8 more
openalex +2 more sources
Comparative study: trimetazidine versus olanzapine on cognitive dysfunction and behavioral changes in ketamine-induced psychosis model in mice [PDF]
The Egyptian Journal of Neurology, Psychiatry and NeurosurgeryBackground Mitochondrial dysfunction and oxidative stress may contribute to schizophrenia. Negative symptoms and cognitive dysfunction in individuals with schizophrenia are resistant to anti-psychotic medications, but physical exercise is an effective ...
Yosra Magdy +4 more
doaj +2 more sources
Role of Trimetazidine in Ameliorating Endothelial Dysfunction: A Review. [PDF]
Pharmaceuticals (Basel)Endothelial dysfunction is a hallmark of cardiovascular diseases, contributing to impaired vasodilation, altered hemodynamics, and atherosclerosis progression. Trimetazidine, traditionally used for angina pectoris, exhibits diverse therapeutic effects on
Kamisah Y, Che Hassan HH.
europepmc +2 more sources
Long-term risk of malignancies in persons with ischemic heart disease treated with trimetazidine dihydrochloride [PDF]
Communications MedicineBackground Metabolic reprogramming of energy processes is a cellular hallmark of various cancers. Whether trimetazidine, an anti-ischemic agent that preferentially potentiates cellular glucose oxidation, alters the long-term risk of malignancies is ...
Yuen-Ting Cheng +8 more
doaj +2 more sources