Effects of trimetazidine on oxidant-antioxidant balance and angiogenesis; an in vivo experimental study [PDF]
BMC Cardiovascular DisordersBackground We evaluated the effects of trimetazidine (TMZ) on the oxidative-antioxidative balance and angiogenesis in an in vivo experimental model. This study aims to evaluate the effects of trimetazidine on angiogenesis through histological analysis ...
Fethullah Kayan, Hasan Basri Savas
doaj +4 more sources
Long-term risk of malignancies in persons with ischemic heart disease treated with trimetazidine dihydrochloride [PDF]
Communications MedicineBackground Metabolic reprogramming of energy processes is a cellular hallmark of various cancers. Whether trimetazidine, an anti-ischemic agent that preferentially potentiates cellular glucose oxidation, alters the long-term risk of malignancies is ...
Yuen-Ting Cheng +8 more
doaj +4 more sources
Effect of trimetazidine on left ventricular functions and cardiac biomarkers in diabetic patients with left ventricular diastolic dysfunction: a randomized controlled trial [PDF]
Scientific ReportsWe investigated the impact of trimetazidine treatment on left ventricular (LV) functions and cardiac biomarkers in diabetic patients with diastolic dysfunction as an early stage of diabetic cardiomyopathy.
Heba Serag +5 more
doaj +3 more sources
Frontiers in Bioscience-LandmarkBackground: Myocardial ischemia-reperfusion (I/R) injury and coronary microcirculation dysfunction (CMD) are observed in patients with myocardial infarction after vascular recanalization.
Xiaolong Qu +3 more
doaj +3 more sources
Trimetazidine-Induced Parkinsonism: A Systematic Review [PDF]
Frontiers in Neurology, 2020 Importance: Trimetazidine (TMZ) is a medication given to patients with stable coronary artery disease. While it is reportedly well-tolerated, there are increasing numbers of reports of adverse events such as parkinsonism. Objectives: The purpose of this study was to systematically review the currently available literature on TMZ-induced parkinsonism ...
Anna Marielle B. Dy +2 more
openalex +4 more sources
Trimetazidine Is Associated With Ameliorated Stroke Risk in Patients With Both Ischemic Heart Disease and Atrial Fibrillation [PDF]
Journal of the American Heart Association: Cardiovascular and Cerebrovascular DiseaseBackground Myocardial ischemia is closely associated with arrhythmogenesis and prognostication in patients with atrial fibrillation (AF). Trimetazidine ameliorates myocardial ischemia through prioritizing cardiomyocyte metabolism to glucose oxidation ...
Yuen‐Ting Cheng +5 more
doaj +2 more sources
Reviews in Cardiovascular Medicine, 2021 Trimetazidine has been reported to benefit patients with heart failure (HF) and angina. The impact of trimetazidine on non-ischemic HF remains unclear.
Chengchen Zhao +3 more
doaj +2 more sources
Pleiotropic effects of trimetazidine
Российский кардиологический журнал, 2013 Aim. To investigate potential pleiotropic effects of trimetazidine (PreductalMB) in patients with stable effort angina. Material and methods. This randomised controlled clinical study included 95 patients with Functional Class I–III stable effort angina ...
O. V. Romashchenko +3 more
doaj +3 more sources
Effect of remote ischemic preconditioning, nicorandil, and trimetazidine in contrast-induced nephropathy: a network meta-analysis of randomized controlled trials [PDF]
Renal FailureIntroduction Contrast-induced nephropathy (CIN) is a potential complication associated with the administration of intravenous contrast agents. The objective of this study was to evaluate the effectiveness of remote ischemic preconditioning (RIPC) and two
Hanchao Gao +8 more
doaj +2 more sources
Trimetazidine stimulates intracellular Ca<sup>2+</sup> transients and zebrafish locomotor activity in spinal neurons. [PDF]
Sci RepBernardi S +4 more
europepmc +3 more sources