Results 31 to 40 of about 12,013 (243)

ACPTI study: Being positive in a negative situation is not naivety – Trimetazidine still has role in symptomatic CAD patients

Indian Heart Journal, 2021
Results: of the efficAcy and safety of Trimetazidine in patients with angina pectoris having been treated by Percutaneous Coronary Intervention (ATPCI) study showed no significant difference in the incidence of primary endpoint events between ...
Jamshed Dalal, Aditya Kapoor
doaj   +1 more source

Metabolic reprogramming promotes myogenesis during aging [PDF]

, 2019
Sarcopenia is the age-related progressive loss of skeletal muscle mass and strength finally leading to poor physical performance. Impaired myogenesis contributes to the pathogenesis of sarcopenia, while mitochondrial dysfunctions are thought to play a ...
Belli, R, Bonato, A, Caruso, M, Costelli, P, De Angelis, L, Ferraro, E., Leigheb, M, Mirabilii, S, Molfino, A, Muscaritoli, M, Ricciardi, Mr, Tafuri, A   +11 more
core   +3 more sources

Trimetazidine Ameliorates Myocardial Metabolic Remodeling in Isoproterenol-Induced Rats Through Regulating Ketone Body Metabolism via Activating AMPK and PPAR α

Frontiers in Pharmacology, 2020
BackgroundMetabolic remodeling plays a vital role in the development of heart failure. The trimetazidine can optimize fatty acid and glucose oxidation via inhibition of long-chain 3-ketoacyl CoA thiolase in the heart.
Huihui Li, Huihui Li, Zhi Ma, Yajun Zhai, Chao Lv, Peng Yuan, Feng Zhu, Liping Wei, Qi Li, Xin Qi   +9 more
doaj   +1 more source

Trimetazidine mitigates high glucose-induced retinal endothelial dysfunction by inhibiting PI3K/Akt/mTOR pathway-mediated autophagy

Bioengineered, 2022
Trimetazidine (TMZ), as a metabolic regulator, has been widely testified to exhibit positive therapeutic effects on various disease models, but its role in diabetic retinopathy has not been reported. Therefore, this study was designed with the purpose of
Qingsong Yang, Sizhen Li, Zixiu Zhou, Xiaodong Yang, Yating Liu, Kuanxiao Hao, M. Fu   +6 more
semanticscholar   +1 more source

Present and future pharmacotherapeutic agents in heart failure: an evolving paradigm [PDF]

, 2016
Many conditions culminate in heart failure (HF), a multi-organ systemic syndrome with an intrinsically poor prognosis. Pharmacotherapeutic agents that correct neurohormonal dysregulation and haemodynamic instability have occupied the forefront of ...
Abozguia, AIRE Study Group, Alexander, Alexander, Alexander, Alexander, Ashrafian, Bailey, Bailey, Basu, Beadle, Braunwald, Brown, Burgoyne, Chaitman, Chatterjee, Chung, CIBIS-II Study Group, Cleland, Clerc, Cohn, Cohn, Cohn, CONSENSUS Trial Study Group, Conway, Cook, Dai, Digitalis Investigation Group, Doenst, Dzau, Dzau, Faris, Flather, Follath, Foster, Fox, Fox, Fragasso, Furberg, Gheorghiade, Gladwin, Goffart, Granger, Greenberg, Guazzi, Guazzi, Heymans, Hobbs, Holubarsch, Horowitz, Horowitz, Kantor, Kapil, Kato, Kennedy, Kennedy, Kostis, Larsen, Lee, Lopaschuk, Luiken, Lundberg, Maher, Maier, Mancini, Mann, Mann, Massie, Mccormack, Mcdowell, Mcmurray, Mcmurray, Merit-Hf Study Group, Munzel, Munzel, Neglia, Neubauer, Ormerod, Packer, Packer, Paul, Pawson, Pfeffer, Pfeffer, Pitt, Pitt, Rathore, Rauchhaus, Redfield, Rona, Sack, Sarraf, Schmidt-Schweda, Schrauwen, Schwarz, Shah, Shah, Siddiqi, Singh, SOLVD Investigators, Stanley, Swedberg, Szwed, Taylor, Teerlink, Tilemann, Torre-Amione, Totzeck, Turcani, Unger, Van Der Vusse, Van Faassen, Vardeny, Webb, Yin, Yusuf, Zamani, Zannad, Zannad, Zhang   +119 more
core   +1 more source

The effectiveness of cytocardioprotection of patients with the moderately expressed post infarct dysfunction of left heart ventricle: the results of the randomization research of trimetazidine and athenolole

Бюллетень сибирской медицины, 2002
With the purpose of research of clinical efficiency of trimetazidine and atenolol and their influence on morfofunctional parameteres of left ventricle 36 men who have transferred a myocardial infarction are inspected.
V. V. Kalyuzhin, M. A. Solovtsov, D. U. Kamaev   +2 more
doaj   +1 more source

Trimetazidine enhances myocardial angiogenesis in pressure overload-induced cardiac hypertrophy mice through directly activating Akt and promoting the binding of HSF1 to VEGF-A promoter

Acta Pharmacologica Sinica, 2022
Latest clinical research shows that trimetazidine therapy during the perioperative period relieves endothelial dysfunction in patients with unstable angina induced by percutaneous coronary intervention. In this study we investigated the effects of TMZ on
Hongyang Shu, Yi-zhong Peng, Weijian Hang, Min Zhang, Lan Shen, Daowen Wang, N. Zhou   +6 more
semanticscholar   +1 more source

Intracoronary trimetazidine does not improve recovery of regional function in a porcine model of repeated ischemia [PDF]

, 1993
We evaluated the effect of trimetazidine (TMZ) on recovery of regional cardiac function in anesthetized open-chest pigs, subjected to fifteen 2-minute occlusions of the left anterior descending coronary artery, separated by 2 minutes of reperfusion and a
Bezstarosti, K. (Karel), Koning, M.M.G. (Monique), Krams, R. (Rob), Lamers, J.M.J. (Jos), Meegen, J.R. (Jan) van, Verdouw, P.D. (Pieter), Xiao, C.S. (C.)   +6 more
core   +1 more source

The Impact of Trimetazidine on Cardiac Fibrosis, Inflammation, and Function in Ischemic Cardiomyopathy Patients

Cardiovascular Drugs and Therapy, 2022
Background Previous studies have shown that Trimetazidine (TMZ) improves vascular endothelial function and reduces the inflammatory process progression.
N. El-khodary, A. Ghoneim, Ahmed A. El-tayaar, Eman M. El-touny   +3 more
semanticscholar   +1 more source

Trimetazidine Reduces Cardiac Fibrosis in Rats by Inhibiting NOX2-Mediated Endothelial-to-Mesenchymal Transition

Drug Design, Development and Therapy, 2022
Purpose Endothelial-to-mesenchymal transition (EndMT) is an important mechanism underlying cardiac fibrosis. The anti-ischemic drug trimetazidine (TMZ) is reportedly useful in ventricular remodeling and associated with NADPH oxidase (NOX) 2.
Xingxing Chen, Xueting Xia, Tiancheng Dong, Zhiwei Lin, Leilei Du, Hao Zhou   +5 more
semanticscholar   +1 more source