Results 61 to 70 of about 12,013 (243)
International Journal of Molecular SciencesAmyotrophic Lateral Sclerosis (ALS) is considered the prototype of motor neuron disease, characterized by motor neuron loss and muscle waste. A well-established pathogenic hallmark of ALS is mitochondrial failure, leading to bioenergetic deficits. So far,
I. Salvatori +17 more
semanticscholar +1 more source
Trimetazidine as a modifier of doxorubicin+cyclophosphamideinduced hyperdyslipidemia
The Siberian Journal of Clinical and Experimental Medicine, 2022 Aim. The present work aimed at studying the proatherogenic potential of doxorubicin-cyclophosphamide (AC) chemotherapy regimen while simultaneously substantiating the use of trimetazidine as a modifier of the changes induced.Material and Methods.
A. Avagimyan, L. V. Kakturskiy
semanticscholar +1 more source
Improving Postdischarge Outcomes in Acute Heart Failure [PDF]
, 2018 The global burden that acute heart failure (AHF) carries has remained unchanged over the past several decades (1). European registries (2–5) showed that 1-year outcome rates remain unacceptably high (Table 1) and confirm that hospitalization for AHF ...
Ambrosy, Andrew P. +8 more
core +1 more source
Pleiotropic effects of trimetazidine
Российский кардиологический журнал, 2013 Aim. To investigate potential pleiotropic effects of trimetazidine (PreductalMB) in patients with stable effort angina. Material and methods. This randomised controlled clinical study included 95 patients with Functional Class I–III stable effort angina ...
O. V. Romashchenko +3 more
doaj +1 more source
Frontiers in Pharmacology, 2021 Background: Viral myocarditis (VMC) is a common emergency of cardiovascular disease. Current treatment for VMC includes the prohibition of exercise plus supportive and symptomatic treatment, given the lack of specific antiviral therapeutic options and ...
Kerui Wu +7 more
doaj +1 more source
Pharmacological screening of substances with cardioprotective effect in the group of 3-oxypyridine derivatives [PDF]
, 2018 Research objectives: To study the anti-hypoxic and cardioprotective effects of 3-oxypyridine derivatives. The search for compounds with an antihypoxic effect was carried out on blood leukocytes of rats in in ...
Danilenko, Lyudmila M. +5 more
core +2 more sources
JPMA. The Journal of the Pakistan Medical AssociationOBJECTIVE To examine the impact of trimetazidine on skeletal muscle function in patients suffering from peripheral artery disease. METHODS The systematic review was conducted from July 20 to November 22, 2022, in line with the Preferred Reporting Items
R. Budiarto +5 more
semanticscholar +1 more source
Evidence-Based Complementary and Alternative Medicine, 2022 This study was intended to explore the effect of proanthocyanidin (PC) combined with trimetazidine in non-small-cell lung cancer (NSCLC) with radiation-induced heart damage (RIHD).
H. Yin +5 more
semanticscholar +1 more source
Considerations for drug trials in hypertrophic cardiomyopathy
ESC Heart Failure, Volume 12, Issue 2, Page 1095-1112, April 2025.Abstract Hypertrophic cardiomyopathy (HCM) is a heterogeneous condition with potentially serious manifestations. Management has traditionally comprised therapies to palliate symptoms and implantable cardioverter‐defibrillators to prevent sudden cardiac death. The need for disease‐modifying therapies has been recognized for decades.
John P. Farrant +17 more
wiley +1 more source
Frontiers in Cardiovascular Medicine, 2022 Aims In-stent restenosis (ISR) is an unresolved problem following percutaneous coronary intervention (PCI), having a negative impact on clinical outcome.
Gábor Csató +8 more
semanticscholar +1 more source