Results 61 to 70 of about 12,230 (281)

Effects of Trimetazidine Pretreatment on Endothelial Dysfunction and Myocardial Injury in Unstable Angina Patients Undergoing Percutaneous Coronary Intervention

Cardiology Research and Practice, 2019
Objectives. Trimetazidine is an anti-ischemic medication licensed for the treatment of angina pectoris. However, the molecular mechanisms underlying its action remain incompletely elucidated. In this study, therefore, we examined the potential beneficial
Shuai Shao, Zhaozhao Shi, Gary Tse, Xinghua Wang, Yanping Ni, Hongmei Liu, Tong Liu, Guangping Li   +7 more
doaj   +1 more source

Effect of trimetazidine on myocardial salvage index in patients with acute ST segment elevation myocardial infarction undergoing primary PCI

The Egyptian Heart Journal, 2013
Introduction: Acute STEMI is the most serious presentation of CAD. Restoration of the coronary flow facilitates cardiomyocyte salvage and decreases cardiac morbidity and mortality. However, reperfusion may result in paradoxical cardiomyocyte dysfunction,
Foad Khaled, Elmahmoudy Ahmed, Bastawy Islam, Khaled Saeed   +3 more
doaj   +1 more source

Effects of Glucose Concentration on Propofol Cardioprotection against Myocardial Ischemia Reperfusion Injury in Isolated Rat Hearts [PDF]

, 2015
published_or_final_versio
Li, Y, Lin, J, Liu, HM, Tao, M, Wang, S, Xia, Z, Yao, X, Zhang, L   +7 more
core   +3 more sources

Repurposing of Trimetazidine for amyotrophic lateral sclerosis: A study in SOD1G93A mice

British Journal of Pharmacology, 2021
Amyotrophic lateral sclerosis (ALS), a neurodegenerative disease characterized by the degeneration of upper and lower motor neurons, progressive wasting and paralysis of voluntary muscles and is currently incurable. Although considered to be a pure motor
Silvia Scaricamazza, I. Salvatori, S. Amadio, V. Nesci, Alessio Torcinaro, G. Giacovazzo, A. Primiano, M. Gloriani, Niccolò Candelise, L. Pieroni, J. Loeffler, F. René, Cyril Quessada, T. Tefera, Hao Wang, F. Steyn, S. Ngo, G. Dobrowolny, E. Lepore, A. Urbani, A. Musarò, C. Volonté, E. Ferraro, R. Coccurello, Cristiana Valle, A. Ferri   +25 more
semanticscholar   +1 more source

The cystathionine γ-lyase/hydrogen sulfide pathway mediates the trimetazidine-induced protection of H9c2 cells against hypoxia/reoxygenation-induced apoptosis and oxidative stress

Anatolian Journal of Cardiology, 2019
Objective: Trimetazidine is a piperazine-derived metabolic agent. It exerts cardioprotective effects against myocardial ischemia/reperfusion (I/R) injury.
Wenqing Zheng, Chao Liu
doaj   +1 more source

Cardiac metabolism — A promising therapeutic target for heart failure [PDF]

, 2017
Both heart failure with reduced ejection fraction (HFrEF) and with preserved ejection fraction (HFpEF) are associated with high morbidity and mortality.
Frenneaux, Michael P, Loudon, Brodie L, Madhani, Melanie, Noordali, Hannah   +3 more
core   +2 more sources

Trimetazidine in cardiovascular medicine

International Journal of Cardiology, 2019
Abnormalities of myocardial energy metabolism appear as a common background of the two major cardiac disorders: ischemic heart disease (IHD) and heart failure (HF). Myocardial ischemia has been recently conceived as a multifaceted syndrome that can be precipitated by a number of mechanisms including metabolic abnormalities. HF is a progressive disorder
Marzilli M., Vinereanu D., Lopaschuk G., Chen Y., Dalal J. J., Danchin N., Etriby E., Ferrari R., Gowdak L. H., Lopatin Y., Milicic D., Parkhomenko A., Pinto F., Ponikowski P., Seferovic P., Rosano G. M. C.   +15 more
openaire   +5 more sources

Trimetazidine and COVID-19-induced acute cardiac injury: a missed key

International Journal of Clinical Pharmacy, 2022
for entry into the host cells [2]. SARS-CoV-2 spike protein binds to ACE2 causing down-regulation of this receptor [2]. ACE2 has a protective effect on cardiomyocytes by reducing angiotensin II (AngII)-induced cardiac fibrosis, hypertrophy, and diastolic
H. Al-kuraishy, A. Al-Gareeb, Nermeen N. Welson, G. Batiha   +3 more
semanticscholar   +1 more source

Trimetazidine and Cardioprotection

Angiology, 2014
Trimetazidine (TMZ) is a metabolic agent used in cardiology for more than 40 years. Several studies assessed the cardioprotective effects of TMZ in patients with chronic coronary heart disease (CHD) as well as in patients with heart failure (HF). In light of the inclusion of TMZ in the current guidelines on the management of stable CHD, we reviewed ...
Tsioufis, K., Andrikopoulos, G., Manolis, A.   +2 more
openaire   +3 more sources

Biochemical Aspects That Lead to Abusive Use of Trimetazidine in Performance Athletes: A Mini-Review

International Journal of Molecular Sciences
Trimetazidine (TMZ), used for treating stable angina pectoris, has garnered attention in the realm of sports due to its potential performance-enhancing properties, and the World Anti-Doping Agency (WADA) has classified TMZ on the S4 list of prohibited ...
Amalia Pușcaș, Ruxandra Ștefănescu, C. Vari, Bianca-Eugenia Ősz, Cristina Filip, Jana Karlina Bitzan, Mădălina-Georgiana Buț, Amelia Tero-Vescan   +7 more
semanticscholar   +1 more source