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Trimethylamine N-Oxide and Risk of Cardiovascular Disease and Mortality
Current Nutrition Reports, 2018Trimethylamine N-oxide (TMAO) is a gut microbiota-dependent metabolite produced from choline and phosphatidylcholine. Trimethylamine N-oxide was found associated with enhanced atherosclerosis and thrombosis in vitro and in vivo. We summarized available clinical studies which investigated TMAO's role in predicting prognostic outcomes, including ...
Chanavuth, Kanitsoraphan +3 more
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Trimethylamine-N-oxide and its biological variations in vegetarians
European Journal of Nutrition, 2016Restriction of animal foods and choline may affect plasma trimethylamine-N-oxide (TMAO). In vegetarians, we investigated the association between TMAO concentrations and the strictness of the diet or sex. We also studied the biological variations of TMAO in vegans.Concentrations of plasma TMAO and choline metabolites were measured in 38 vegans and 67 ...
Obeid, Rima +3 more
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Trimethylamine N-oxide suppresses the activity of the actomyosin motor
Biochimica et Biophysica Acta (BBA) - General Subjects, 2012During actomyosin interactions, the transduction of energy from ATP hydrolysis to motility seems to occur with the modulation of hydration. Trimethylamine N-oxide (TMAO) perturbs the surface of proteins by altering hydrogen bonding in a manner opposite to that of urea.
Ryusei, Kumemoto +3 more
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Current Opinion in Lipidology, 2016
This article evaluates the link between trimethylamine-N-oxide (TMAO) and bile acids and the consequent impact on the development of atherosclerosis.Elevation in plasma TMAO concentrations is associated with an increased risk of cardiovascular disease in many different patient cohorts.
Aze, Wilson +2 more
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This article evaluates the link between trimethylamine-N-oxide (TMAO) and bile acids and the consequent impact on the development of atherosclerosis.Elevation in plasma TMAO concentrations is associated with an increased risk of cardiovascular disease in many different patient cohorts.
Aze, Wilson +2 more
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Trimethylamine-N-oxide modulates the reductive unfolding of onconase
Biochemical and Biophysical Research Communications, 2004The physiological osmolyte trimethylamine-N-oxide (TMAO) stabilizes proteins by decreasing the entropy of the unfolded state through a solvophobic effect. Our studies on the effect of TMAO on the reductive unfolding of onconase (ONC) to form its reductive intermediate, des [30-75], indicate that TMAO diminishes the reductive unfolding rate of the ...
Robert F, Gahl +3 more
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Gut Microbial Metabolite Trimethylamine N -Oxide Aggravates Pulmonary Hypertension
American Journal of Respiratory Cell and Molecular Biology, 2022Kai Yang, Haiyang Tang, Jian Wang
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